Toll-like receptor (TLR) pathway defects

TLR: toll-like receptor; MyD88: myeloid differentiation primary response protein 88; IRAK: interleukin-1 receptor-associated kinase; TRAF: tumor necrosis factor (TNF) receptor-associated factor; TAK1: transforming growth factor (TGF)-beta-activated protein kinase 1; IRF: interferon regulatory factor; NEMO: nuclear factor (NF)-kappa-B essential modulator; IKK: inhibitor of nuclear factor (NF)-kappa-B kinase; NF-kappa-B: nuclear factor (NF) for the kappa light chain enhancer in B cells; MAPKs: mitogen-activated protein kinases; AP1: activating protein-1; MAL: MyD88 adapter-like; TRAM: TRIF-related adapter molecule; TRIF: toll/interleukin-1 (IL-1) receptor (TIR) domain-containing adapter-inducing interferon-beta (IFN-beta); TBK1: tank-binding kinase 1; IKKi: I-kappa-B kinase i; UNC93B: UNC93 homolog B; RIP1: receptor-interacting protein kinase-1; BTK: Bruton tyrosine kinase; OPNi: osteopontin i.