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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 2 مورد

Polycystic ovary syndrome etiology as a complex trait involving two hits

Polycystic ovary syndrome etiology as a complex trait involving two hits
Congenital predisposing "hit"
  • Heritable traits and gene variants affecting ovarian function
  • Heritable traits and gene variants predisposing to insulin resistance, obesity, and type 2 diabetes mellitus
  • Congenital virilization
  • Disturbed fetal nutrition
Postnatal provocative "hit"
  • Insulin-resistant hyperinsulinemia
    • Metabolic syndrome
    • Postnatal obesity
  • Puberty
Modified from: Rosenfield RL, Ehrmann DA. The pathogenesis of polycystic ovary syndrome (PCOS): The hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocrine Reviews 2016; 37:467. By permission of Oxford University Press on behalf of The Endocrine Society. Copyright © 2016.
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