Surgical specimen-staining pattern | Biopsy specimen-staining pattern | Score | HER2 expression assessment |
No reactivity or membranous reactivity in <10% of tumor cells | No reactivity or no membranous reactivity in any tumor cell | 0 | Negative |
Faint/barely perceptible membranous reactivity in ≥10% of tumor cells; cells are reactive only in part of their membrane | Tumor cell cluster* with a faint/barely perceptible membranous reactivity irrespective of percentage of tumor cells stained | 1+ | Negative |
Weak to moderate, complete, basolateral or lateral membranous reactivity in ≥10% of tumor cells | Tumor cell cluster* with a weak to moderate, complete, basolateral or lateral membranous reactivity irrespective of percentage of tumor cells stained | 2+ | Equivocal |
Strong, complete, basolateral or lateral membranous reactivity in ≥10% of tumor cells | Tumor cell cluster* with a strong, complete, basolateral or lateral membranous reactivity irrespective of percentage of tumor cells stained | 3+ | Positive |
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