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Medullary thyroid carcinoma TNM staging AJCC UICC 8th edition

Medullary thyroid carcinoma TNM staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
T1 Tumor ≤2 cm in greatest dimension limited to the thyroid
T1a Tumor ≤1 cm in greatest dimension limited to the thyroid
T1b Tumor >1 cm but ≤2 cm in greatest dimension limited to the thyroid
T2 Tumor >2 cm but <4 cm in greatest dimension limited to the thyroid
T3 Tumor ≥4 cm or with extrathyroidal extension
T3a Tumor ≥4 cm in greatest dimension limited to the thyroid
T3b Tumor of any size with gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid or omohyoid muscles)
T4 Advanced disease
T4a Moderately advanced disease.
Tumor of any size with gross extrathyroidal extension into the nearby tissues of the neck, including subcutaneous soft tissue, larynx, trachea, esophagus, or recurrent laryngeal nerve.
T4b Very advanced disease.
Tumor of any size with extension toward the spine or into nearby large blood vessels, gross extrathyroidal extension invading the prevertebral fascia, or encasing the carotid artery or mediastinal vessels.
Regional lymph nodes (N)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No evidence of locoregional lymph node metastasis
N0a One or more cytologically or histologically confirmed benign lymph nodes
N0b No radiologic or clinical evidence of locoregional lymph node metastasis
N1 Metastasis to regional nodes
N1a Metastasis to level VI or VII (pretracheal, paratracheal, or prelaryngeal/Delphian, or upper mediastinal) lymph nodes. This can be unilateral or bilateral disease.
N1b Metastasis to unilateral, bilateral, or contralateral lateral neck lymph nodes (levels I, II, III, IV, or V) or retropharyngeal lymph nodes
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
T1 N0 M0 I
T2 N0 M0 II
T3 N0 M0 II
T1-3 N1a M0 III
T4a Any N M0 IVA
T1-3 N1b M0 IVA
T4b Any N M0 IVB
Any T Any N M1 IVC
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
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