Normal human blood lymphocyte subpopulations at various ages

Subpopulations	Age groups
Subpopulations	Core blood	2 to 3 months	4 to 8 months	12 to 23 months	2 to 5 years	7 to 17 years	Adult
Total lymphocytes
Median cells/uL (% total leukocytes)	5400 (41%)	5680 (66%)	5990 (64%)	5160 (59%)	4060 (50%)	2400 (40%)	2100 (32%)
Confidence intervals	4200 (35%) to 6900 (47%)*	2920 (55%) to 8840 (78%)	3610 (45%) to 8840 (79%)	2180 (44%) to 8270 (72%)	2400 (38%) to 5810 (64%)	2000 (36%) to 2700 (43%)*	1600 (28%) to 2400 (39%)*
CD3 T cells
Median cells/uL (% total lymphocytes)	3100 (55%)	4030 (72%)	4270 (71%)	3300 (66%)	3040 (72%)	1800 (70%)	1600 (73%)
Confidence intervals	2400 (49%) to 3700 (62%)*	2070 (55%) to 6540 (78%)	2280 (45%) to 6450 (79%)	1460 (53%) to 5440 (81%)	1610 (62%) to 4230 (80%)	1400 (66%) to 2000 (76%)*	960 (61%) to 2600 (84%)*
CD4 T cells
Median cells/uL (% total lymphocytes)	1900 (35%)	2830 (52%)	2950 (49%)	2070 (43%)	1800 (42%)	800 (37%)	940 (46%)
Confidence intervals	1500 (28%) to 2400 (42%)*	1460 (41%) to 5116 (64%)	1690 (36%) to 4600 (61%)	1020 (31%) to 3600 (54%)	900 (35%) to 2860 (51%)	700 (33%) to 1100 (41%)*	540 (32%) to 1660 (60%)*
CD8 T cells
Median cells/uL (% total lymphocytes)	1500 (29%)	1410 (25%)	1450 (24%)	1320 (25%)	1180 (30%)	800 (30%)	520 (27%)
Confidence intervals	1200 (26%) to 2000 (33%)*	650 (16%) to 2450 (35%)	720 (16%) to 2490 (34%)	570 (16%) to 2230 (38%)	630 (22%) to 1910 (38%)	600 (27%) to 900 (35%)*	270 (13%) to 930 (40%)*
B cells^¶
Median cells/uL (% total lymphocytes)	1000 (20%)^¶	900 (23%)	900 (23%)	900 (23%)	900 (24%)	400 (16%)^¶	246 (13%)^¶
Confidence intervals	200 (14%) to 1500 (23%)*	500 (19%) to 1500 (31%)	500 (19%) to 1500 (31%)	500 (19%) to 1500 (31%)	700 (21%) to 1300 (28%)	300 (12%) to 500 (22%)*	122 (10%) to 632 (31%)*
CD4:CD8 ratio
Median	1.2	2.2	2.1	1.6	1.4	1.3	1.7
Confidence intervals	0.8 to 1.8	1.3 to 3.5	1.2 to 3.5	1.0 to 3.0	1.0 to 2.1	1.1 to 1.4	0.9 to 4.5

Confidence intervals given are the 5^th to 95^th percentiles except where indicated (*). B cells use the CD20 antigen except where indicated (^¶).
Each subgroup contains at least 22 health subjects.

* These are the 25^th to 75^th percentiles.
¶ These use the CD19 antigen.

This book chapter was published in Immunologic Disorders in Infants and Children, 5th ed, Stiehm ER, Ochs HD, Winkelstein JA, Immunodeficiency disorders: General considerations, 311, Copyright Elsevier (2004).

Graphic 110585 Version 1.0

خرید پکیج

Normal human blood lymphocyte subpopulations at various ages