Protein C and S function in the termination of coagulation

Protein C is activated on the endothelial cell membrane, where it is anchored by the endothelial protein C receptor. Activated protein C and protein S assemble on the platelet membrane. Protein S acts as a cofactor for protein C in proteolytically cleaving activated factors V and VIII (factors Va and VIIIa).

TM: thrombomodulin; T: thrombin; EPCR: endothelial protein C receptor; PC: protein C; PS: protein S; APC: activated protein C; Va: activated factor V; VIIIa: activated factor VIII.

Reproduced with permission from: Bunn HF, Bauer KA. Thrombotic Disorders. In: Pathophysiology of Blood Disorders, Bunn HF, Aster JC (Eds), McGraw-Hill Education, New York 2011. Copyright © 2011 McGraw-Hill Education. McGraw-Hill Education makes no representations or warranties as to the accuracy of any information contained in the McGraw-Hill Education Material, including any warranties of merchantability or fitness for a particular purpose. In no event shall McGraw-Hill Education have any liability to any party for special, incidental, tort, or consequential damages arising out of or in connection with the McGraw-Hill Education Material, even if McGraw-Hill Education has been advised of the possibility of such damages.

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Protein C and S function in the termination of coagulation