Cytogenetic abnormalities diagnostic of acute myeloid leukemia with myelodysplasia-related changes

Complex karyotype (3 or more abnormalities)

Unbalanced abnormalities

–7/del(7q)

del(5q)/t(5q)

i(17q)/t(17p)

–13/del(13q)

del(11q)

del(12p)/t(12p)

idic(X)(q13)

Balanced abnormalities

t(11;16)(q23.3;p13.3)

t(3;21)(q26.2;q22.1)

t(1;3)(p36.3;q21.2)

t(2;11)(p21;q23.3)

t(5;12)(q32;p13.2)

t(5;7)(q32;q11.2)

t(5;17)(q32;p13.2)

t(5;10)(q32;q21.2)

t(3;5)(q25.3;q35.1)

The cytogenetic abnormalities listed are sufficient to diagnose acute myeloid leukemia with myelodysplasia-related changes when ≥20% peripheral blood or bone marrow blasts are present and prior therapy has been excluded.

Republished with permission of the American Society of Hematology, from Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127:2391. Copyright © 2016; permission conveyed through Copyright Clearance Center, Inc.

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Cytogenetic abnormalities diagnostic of acute myeloid leukemia with myelodysplasia-related changes