Cytogenetically defined risk-based classification of smoldering multiple myeloma

Risk	Cytogenetic finding
High	t(4;14) del(17p) 1q gain
Intermediate	Trisomies without IgH translocation
Standard	Other IgH translocations including t(11;14), t(14;16), and t(14;20) Presence of trisomies and IgH translocation, except t(4;14) Monosomy13/del(13q)
Low	No abnormalities (normal or insufficient)

IgH: immunoglobulin heavy chain.

Adapted from:

Rajkumar SV, Gupta V, Fonseca R, et al. Impact of primary molecular cytogenetic abnormalities and risk of progression in smoldering multiple myeloma. Leukemia 2013; 27:1738.

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