WHO classification of circumscribed astrocytic tumors

Tumor type	CNS WHO grade	Characteristic molecular genetic alterations
Pilocytic astrocytoma	1	KIAA1549-BRAF, BRAF
High-grade astrocytoma with piloid features	NA	Methylome
Pleomorphic xanthoastrocytoma	2, 3	BRAF, CDKN2A
Subependymal giant cell astrocytoma	1	TSC1, TSC2
Chordoid glioma	2	PRKCA
Astroblastoma, MN1-altered	NA	MN1, BEND2

WHO: World Health Organization; CNS: central nervous system; NA: not assigned; CDKN2A: cyclin-dependent kinase inhibitor 2A; TSC: tuberous sclerosis complex; PRKCA: protein kinase C alpha; BEND2: BEN domain containing 2.

Adapted from: WHO Classification of Tumours Editorial Board. Central nervous system tumours. Lyon (France): International Agency for Research on Cancer; 2021. (WHO classification of tumours series, 5th ed.; vol. 6).

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WHO classification of circumscribed astrocytic tumors