| Time point of interruption | Details of interruption | Approach |
| During intensive phase | - Lapse is <14 days in duration
| - Continue treatment to complete planned total number of doses (as long as all doses are completed within 3 months)
|
- Lapse is ≥14 days in duration
| - Restart treatment from the beginning
|
| During continuation phase | - Received ≥80 percent of doses and sputum was AFB smear negative on initial testing
| - Further therapy may not be necessary
|
- Received ≥80 percent of doses and sputum was AFB smear positive on initial testing
| - Continue therapy until all doses are completed
|
- Received <80 percent of doses and accumulative lapse is <3 months in duration
| - Continue therapy until all doses are completed (full course), unless consecutive lapse is >2 months
- If treatment cannot be completed within recommended time frame for regimen, restart therapy from the beginning (ie, restart intensive phase, to be followed by continuation phase)¶
|
- Received <80 percent of doses and lapse is ≥3 months in duration
| - Restart therapy from the beginning, new intensive and continuation phases (ie, restart intensive phase, to be followed by continuation phase)
|
