World Health Organization (WHO) classification of medulloblastoma, grade 4

Tumor type	Subgroups and patterns
Medulloblastomas, genetically defined
Medulloblastoma, Wnt-activated
Medulloblastoma, SHH-activated and TP53-mutant Medulloblastoma, SHH-activated and TP53-wildtype	4 methylome-based subgroups
Medulloblastoma, non-Wnt/non-SHH (group 3 and 4)	8 methylome-based subgroups
Medulloblastomas, histologically defined
	4 morphologic patterns: Classic Desmoplastic/nodular Extensive nodularity Large cell/anaplastic

SHH: sonic hedgehog; TP53: tumor protein 53; Wnt: Wingless-related integration site.

Adapted from Central Nervous System Tumours: WHO Classification of Tumours, 5th ed, Vol. 6, WHO Classification of Tumours Editorial Board, ICD-O morphological coding, page 3. Copyright © 2021 International Agency for Research on Cancer. https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/Central-Nervous-System-Tumours-2021 (Accessed on April 26, 2024).

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