Differential diagnosis of CD8⁺ cutaneous T cell lymphomas

Type of cutaneous lymphoma	Frequency of CD8 expression (%)	Helpful distinguishing features
Aggressive epidermotropic CD8⁺ cytotoxic CTCL	100	Ulcerating plaques, nodules and tumors, no prior or concurrent eczematous patches/plaques
Early patch/plaque-stage MF	~15	Prior or concurrent eczematous patches/plaques^*
Tumor-stage/transformed MF	~5	(Ulcerating) tumors, prior or concurrent eczematous patches/plaques^*
Pagetoid reticulosis	~50	Solitary, slowly expanding plaque usually on the extremities
C-ALCL	<5	Solitary or localized (ulcerating) tumors, tendency to spontaneous remission^*
LyP, type D	100	Recurrent self-healing popular, nodular or ulceronecrotic skin lesions^*
SPTCL	>90	Subcutaneous nodules and plaques, no ulceration, no epidermal involvement
Primary cutaneous acral CD8⁺ T cell lymphoproliferative disorder	100	Slowly progressive nodule on ear and other acral sites, no ulceration, no epidermal involvement, low proliferation rate

C-ALCL: cutaneous anaplastic large cell lymphoma; CTCL: cutaneous T cell lymphoma; LyP: lymphomatoid papulosis; MF: mycosis fungoides; SPTCL: subcutaneous panniculitis-like T cell lymphoma.

* No difference in clinical presentation and prognosis between CD8⁺ and more common CD4⁺ cases.

Original figure modified for this publication. Willemze R. CD30-Negative Cutaneous T-Cell Lymphomas Other than Mycosis Fungoides. Surg Pathol Clin 2014; 7:229. Table used with the permission of Elsevier Inc. All rights reserved.

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Differential diagnosis of CD8+ cutaneous T cell lymphomas

Differential diagnosis of CD8⁺ cutaneous T cell lymphomas