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خرید پکیج

تعداد آیتم قابل مشاهده باقیمانده : 3 مورد

Overview of clinical manifestations of sickle cell disease

Overview of clinical manifestations of sickle cell disease

	Acute	Chronic
Pain	Acute vaso-occlusive pain episodes, acute chest syndrome	Pain from tissue infarction, osteonecrosis, ulcers
Infection	Sepsis, pneumonia, meningitis	Functional asplenia, leg ulcers, osteomyelitis
Anemia	Aplastic crisis, splenic sequestration crisis, hyperhemolytic crisis	Compensated hemolytic anemia, chronic hypersplenism
CNS	Ischemic stroke, hemorrhagic stroke, seizures, TIA	Silent cerebral infarctions, cognitive delay, behavioral issues
Pulmonary	Acute chest syndrome, asthma, pulmonary fat embolism, pulmonary thromboembolism	Pulmonary hypertension, sleep disordered breathing, chronic restrictive lung disease
Kidney	Kidney infarction, medication toxicity, hematuria, acute kidney injury, acute nephrotic syndrome	Hypertension, chronic kidney failure, concentrating defect, nephrogenic diabetes insipidus, renal medullary carcinoma
Skeletal	Dactylitis, avascular necrosis	Osteoporosis, osteomyelitis
Cardiac	Myocardial infarction, dysrhythmia, sudden death, autonomic dysfunction	Diastolic dysfunction, heart failure
Hepatobiliary	Hepatic sequestration crisis, cholecystitis, liver injury, acute intrahepatic cholestasis	Pigment gallstones
Ocular	Retinal artery occlusion, hyphema, retinal detachment	Proliferative retinopathy, blindness
Obstetric	Fetal and maternal complications
Genitourinary	Priapism	Erectile dysfunction
Endocrine		Delayed puberty, reduced growth
Other	Multi-organ failure, venous thromboembolism	Psychosocial stress and decreased mental health

Refer to UpToDate for additional information on screening, diagnosis, and management of these complications.

SCD: sickle cell disease; CNS: central nervous system; TIA: transient ischemic attack.

Graphic 108318 Version 4.0

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