Classification of HDL by physical properties

Method	HDL classification
Method	Very large (HDL-VL)	Large (HDL-L)	Medium (HDL-M)	Small (HDL-S)	Very small (HDL-VS)
Analytical ultracentrifugation	1.063 to 1.087	1.088 to 1.110	1.110 to 1.129	1.129 to 1.154	1.154 to 1.21
Size range (nm)	12.9 to 9.7	9.7 to 8.8	8.8 to 8.2	8.2 to 7.8	7.8 to 7.2
Density gradient ultracentrifugation	HDL 2b	HDL 2a	HDL 3a	HDL 3b	HDL 3c
Density range (g/mL)	1.063 to 1.087	1.088 to 1.110	1.110 to 1.129	1.129 to 1.154	1.154 to 1.170
Gradient gel electrophoresis	HDL 2b	HDL 2a	HDL 3a	HDL 3b	HDL 3c
2D gel electrophoresis	Alpha-1	Alpha-2	Alpha-3	Alpha-4	Pre-beta-1 HDL
Size range (nm)	11.2 to 10.8	9.4 to 9.0	8.5 to 7.5	7.5 to 7.0	6.0 to 5.0
Nuclear magnetic resonance spectroscopy	Large HDL-P	Medium HDL-P		Small HDL-P
Size range (nm)	12.9 to 9.7	9.7 to 8.8	8.8 to 8.2	8.2 to 7.8	7.8 to 7.2
Ion mobility	HDL 2b	HDL 2a + 3
Size range (nm)	14.5 to 10.5	10.5 to 7.65

HDL: high density lipoprotein; HDL-P: HDL particle concentration.

Adapted with permission of the American Association For Clinical Chemistry, from: Rosenson RS, Brewer HB Jr, Chapman MJ, et al. HDL Measures, HDL Particle Heterogeneity, Proposed HDL Nomenclature and Relation to Atherosclerotic Cardiovascular Events. Clin Chem 2011; 57:392; permission conveyed through Copyright Clearance Center, Inc. Copyright © 2011.

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Classification of HDL by physical properties