Parenteral antibiotics for initiation of therapy |
Antibiotic agent | Dosing |
GA <32 weeks | GA ≥32 weeks |
Cefazolin | - Age <7 days: 25 mg/kg IV every 12 hours
- Age ≥7 days: 25 mg/kg IV every 8 hours
| - Age ≤7 days: 50 mg/kg IV every 12 hours
- Age >7 days: 50 mg/kg IV every 8 hours
|
Cefotaxime | - Age <7 days: 50 mg/kg IV every 12 hours
Age ≥7 days: 50 mg/kg IV every 8 hours |
Ceftazidime |
Ceftriaxone* | - 50 mg/kg IV every 24 hours
|
Clindamycin¶ | - PMA ≤32 weeks: 5 mg/kg IV every 8 hours
- PMA 33 to 40 weeks: 7 mg/kg IV every 8 hours
- PMA >40 weeks: 9 mg/kg IV every 8 hours
|
Antibiotic agent | Dosing |
GA <36 weeks | GA ≥36 weeks |
Cefepime | - 30 mg/kg IV every 12 hours
| - 50 mg/kg IV every 12 hours
|
Antibiotic agent | Dosing |
GA ≥34 weeks and age ≥12 days |
Ceftaroline | |
Antibiotic agent | Dosing |
GA <30 weeks | GA 30 to 34 weeks | GA ≥35 weeks |
GentamicinΔ | - Age ≤14 days: 5 mg/kg IV every 48 hours
- Age >14 days: 5 mg/kg IV every 36 hours
| - Age ≤10 days: 5 mg/kg IV every 36 hours
- Age >10 days: 5 mg/kg IV every 24 hours
| - Age ≤7 days: 4 mg/kg IV every 24 hours
- Age >7 days: 5 mg/kg IV every 24 hours
|
Antibiotic agent | Dosing |
Age ≤7 days | Age 8 to 28 days |
Linezolid | - GA <34 weeks: 10 mg/kg IV every 12 hours
- GA ≥34 weeks: 10 mg/kg IV every 8 hours
| - 10 mg/kg IV every 8 hours
|
Nafcillin | - GA ≤34 weeks: 25 mg/kg IV every 12 hours
- GA >34 weeks: 25 mg/kg IV every 8 hours
| - GA ≤34 weeks: 25 mg/kg IV every 8 hours
- GA >34 weeks: 25 mg/kg IV every 6 hours
|
Oxacillin | - GA ≤34 weeks: 25 mg/kg IV every 12 hours
- GA >34 weeks: 25 mg/kg IV every 8 hours
| - GA ≤34 weeks: 25 mg/kg IV every 8 hours
- GA >34 weeks: 25 mg/kg IV every 6 hours
|
Piperacillin-tazobactam◊ | - PMA ≤30 weeks: 100 mg/kg IV every 8 hours
- PMA >30 weeks: 80 mg/kg IV every 6 hours
|
Vancomycin§ | Begin with a loading dose of 20 mg/kg followed by maintenance dosing according to GA and serum creatinine as indicated below. The interval between the loading dose and the first maintenance dose should be the same as the dosing interval for the maintenance regimen. This dosing regimen was designed with a target trough concentration of 5 to 10 mg/L[1]. |
GA ≤28 weeks | GA >28 weeks |
Serum creatinine | Dose and frequency | Serum creatinine | Dose and frequency |
| - 15 mg/kg IV every 12 hours
| | - 15 mg/kg IV every 12 hours
|
| - 20 mg/kg IV every 24 hours
| | - 20 mg/kg IV every 24 hours
|
| - 15 mg/kg IV every 24 hours
| | - 15 mg/kg IV every 24 hours
|
| - 10 mg/kg IV every 24 hours
| | - 10 mg/kg IV every 24 hours
|
| - 15 mg/kg IV every 48 hours
| | - 15 mg/kg IV every 48 hours
|
Oral antibiotics for completion of therapy¥ |
Antibiotic agent | Dosing |
Age ≤7 days | Age 8 to 28 days |
Cephalexin | - Oral therapy not appropriate
| - 6.25 to 12.5 mg/kg orally every 6 hours
|
Clindamycin¶ | - PMA ≤32 weeks: 5 mg/kg orally every 8 hours
- PMA 33 to 40 weeks: 7 mg/kg orally every 8 hours
- PMA >40 weeks: 9 mg/kg orally every 8 hours
|
Linezolid‡ | - GA <34 weeks: 10 mg/kg orally every 12 hours
- GA ≥34 weeks: 10 mg/kg orally every 8 hours
| - 10 mg/kg orally every 8 hours
|