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Brighton criteria for case definition of Guillain-Barré syndrome

Brighton criteria for case definition of Guillain-Barré syndrome
Level 1 of diagnostic certainty Level 2 of diagnostic certainty Level 3 of diagnostic certainty
  • Bilateral and flaccid weakness of the limbs; AND
  • Decreased or absent deep tendon reflexes in weak limbs; AND
  • Monophasic illness pattern; and interval between onset and nadir of weakness between 12 hours and 28 days; and subsequent clinical plateau; AND
  • Absence of identified alternative diagnosis for weakness; AND
  • Cytoalbuminologic dissociation (ie, elevation of CSF protein level above laboratory normal value and CSF total white cell count <50 cells/microL; AND
  • Electrophysiologic findings consistent with GBS
  • Bilateral and flaccid weakness of the limbs; AND
  • Decreased or absent deep tendon reflexes in weak limbs; AND
  • Monophasic illness pattern; and interval between onset and nadir of weakness between 12 hours and 28 days; and subsequent clinical plateau; AND
  • Absence of identified alternative diagnosis for weakness; AND
  • CSF total white cell count <50 cells/microL (with or without CSF protein elevation above laboratory normal value); OR electrophysiologic studies consistent with GBS if CSF not collected or results not available
  • Bilateral and flaccid weakness of the limbs; AND
  • Decreased or absent deep tendon reflexes in weak limbs; AND
  • Monophasic illness pattern; and interval between onset and nadir of weakness between 12 hours and 28 days; and subsequent clinical plateau; AND
  • Absence of identified alternative diagnosis for weakness
CSF: cerebrospinal fluid; GBS: Guillain-Barré syndrome.
Reproduced from: Sejvar JJ, Kohl KS, Gidudu J, et al. Guillain-Barré syndrome and Fisher syndrome: case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine 2011; 29:599. Table used with the permission of Elsevier Inc. All rights reserved.
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