Antiseizure medications with the potential to worsen generalized seizure types

Seizure type and patient population	Medications with potential to precipitate or aggravate seizures*
Generalized-onset tonic-clonic seizures in children and adults	Carbamazepine, phenytoin
Absence seizures in children	Carbamazepine, oxcarbazepine, phenobarbital, phenytoin, tiagabine, and vigabatrin
Absence seizures, myoclonic seizures, and in some cases generalized-onset tonic-clonic seizures in patients with juvenile myoclonic epilepsy	Carbamazepine, gabapentin, lamotrigine^¶, oxcarbazepine, phenytoin, tiagabine, vigabatrin

* Low-quality evidence, based primarily on scattered reports.
¶ Myoclonic seizures only, also reported in other generalized epilepsy syndromes.

Glauser T, Ben-Menachem E, Bourgeois B, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 54:551-63; 2013.

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Antiseizure medications with the potential to worsen generalized seizure types