Infectious organism | Test method used and comments on testing |
Babesia microti (babesiosis) | Units collected in high-risk regions of the United States undergo nucleic acid minipool testing for parasite nucleic acid |
Cytomegalovirus | Selected units are tested to establish a CMV-negative inventory for at-risk recipients, using an immunoassay for anti-CMV antibodies |
Hepatitis B virus | All units; immunoassay for HBsAg and HBc antibody and nucleic acid minipool testing for viral DNA |
Hepatitis C virus | All units; immunoassay for antibody and nucleic acid minipool testing for viral RNA |
HIV-1 and 2 | All units; immunoassay for antibody (with further confirmation testing if reactive) and nucleic acid minipool testing for viral RNA |
HTLV-I and II | All units; immunoassay for antibody (with further confirmation testing if reactive) |
Treponema pallidum (syphilis) | All units; usually immunoassay for T. pallidum-specific antibody; may also perform an additional non-treponemal immunoassay on reactive samples to help determine when infection occurred |
Trypanosoma cruzi (Chagas disease) | Initial donation from all donors; immunoassay for antibody (with further confirmation testing if reactive) |
West Nile virus | All units; nucleic acid minipool or individual donation testing for viral RNA |
Zika virus | Previously all units, using nucleic acid minipool or individual donation testing for viral RNA; phased out in 2021 due to diminished risk |
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