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Brain magnetic resonance imaging of an infant with HSV CNS disease

Brain magnetic resonance imaging of an infant with HSV CNS disease
Coronal T2 weighted post-contrast MRI of the brain in a two week-old term infant with early HSV encephalitis showing focal subacute hemorrhage and inflammation within cortex and overlying subarachnoid space of the left front lobe (arrow).
The infant presented with lethargy, poor feeding, seizure-like activity, and one small facial vesicular skin lesion. HSV PCR testing of blood and CSF was positive for HSV type 2 DNA. She was treated with 21 days of IV acyclovir followed by oral suppressive therapy for six months. At two years of age she had motor disabilities with hemiparesis but normal speech and language abilities.
MRI: magnetic resonance imaging; HSV: herpes simplex virus; CNS: central nervous system; PCR: polymerase chain reaction; CSF: cerebrospinal fluid; DNA: deoxyribonucleic acid; IV: intravenous.
Graphic 106590 Version 1.0

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