Condition | Mechanism(s) |
Primary TMAs* | Intravascular RBC shearing and platelet microthrombi |
TTP | Ultralarge VWF multimers and platelet microthrombi |
HUS | Damaged endothelium and platelet microthrombi |
Complement-mediated TMA | Damaged endothelium and platelet microthrombi |
Systemic conditions | Intravascular RBC shearing and platelet/fibrin thrombi |
DIC | Intravascular platelet/fibrin thrombi |
HELLP and preeclampsia | Damaged endothelium and platelet microthrombi |
Malignancy | Shearing within intravascular tumor deposits |
Malignant hypertension | Damaged endothelium and platelet microthrombi |
Scleroderma renal crisis | Damaged endothelium and platelet microthrombi |
APS | Intravascular thrombi |
Isolated intravascular sites of hemolysis | Intravascular RBC shearing by turbulence and/or mechanical trauma in the isolated site |
Kasabach-Merritt syndrome | Platelet trapping and localized intravascular coagulation within the angioma |
TIPS | Shear stress and mechanical trauma in the shunt |
Malfunctioning cardiac valves or cardiac assist devices | Shear stress and mechanical trauma across the valve or assist device |
March hemoglobinuria, extreme running, bongo drumming | Repetitive trauma as blood passes through vessels in feet or hands |
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟