Manifestations of acute rheumatic fever

	Percent
Major manifestations
Carditis and valvulitis (eg, pancarditis) that is clinical or subclinical	50 to 70%
Arthritis (usually migratory polyarthritis predominantly involving the large joints)	35 to 66%
Central nervous system involvement (eg, Sydenham chorea)	10 to 30%
Subcutaneous nodules	0 to 10%
Erythema marginatum	<6%
Minor manifestations
Arthralgia
Fever
Elevated acute phase reactants (ESR, CRP)
Prolonged PR interval on electrocardiogram

ESR: erythrocyte sedimentation rate; CRP: C-reactive protein.

Data from: Gewitz MH, Baltimore RS, Tani LH, et al. Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: A scientific statement from the American Heart Association. Circulation 2015; 131:1806.

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Manifestations of acute rheumatic fever