Overall survival by Revised International Staging System (R-ISS) in multiple myeloma

Overall survival in patients with multiple myeloma stratified by R-ISS. Median OS was not reached for patients included in R-ISS stage I, whereas it was 83 months for R-ISS stage II and 43 months for R-ISS stage III. R-ISS I was defined by ISS stage I (B2M <3.5 mg/L and serum albumin ≥3.5 g/dL) and normal LDH and no del(17p), t(4;14) or t(14;16) by FISH. R-ISS II was defined as those not meeting criteria for R-ISS I or III. R-ISS III was defined by ISS stage III (B2M ≥5.5 mg/L) plus LDH above normal limits and/or detection of one of the following by FISH: del(17p), t(4;14) or t(14;16).