Version June 2024
| Clinical stage 1 |
| Asymptomatic |
| Persistent generalized lymphadenopathy |
| Clinical stage 2 |
| Unexplained persistent hepatosplenomegaly |
| Papular pruritic eruptions |
| Fungal nail infection |
| Angular cheilitis |
| Lineal gingival erythema |
| Extensive wart virus infection |
| Extensive molluscum contagiosum |
| Recurrent oral ulcerations |
| Unexplained persistent parotid enlargement |
| Herpes zoster |
| Recurrent or chronic upper respiratory tract infections (otitis media, otorrhea, sinusitis or tonsillitis) |
| Clinical stage 3 |
| Unexplained* moderate malnutrition or wasting not adequately responding to standard therapy |
| Unexplained persistent diarrhea (14 days or more) |
| Unexplained persistent fever (above 37.5°C intermittent or constant for longer than 1 month) |
| Persistent oral candidiasis (after first 6 to 8 weeks of life) |
| Oral hairy leukoplakia |
| Acute necrotizing ulcerative gingivitis or periodontitis |
| Lymph node tuberculosis |
| Pulmonary tuberculosis |
| Severe recurrent bacterial pneumonia |
| Symptomatic lymphoid interstitial pneumonitis |
| Chronic HIV-associated lung disease including bronchiectasis |
| Unexplained anemia (hemoglobin <8 g/dL), neutropenia (ANC <500 cells/microL [<0.5 × 109/L]) and or chronic thrombocytopenia (platelet count <50,000 cells/micoL [<50 × 109 per litre]) |
| Clinical stage 4¶ |
| Unexplained severe wasting, stunting, or severe malnutrition not responding to standard therapy |
| Pneumocystis pneumonia |
| Recurrent severe bacterial infections (such as empyema, pyomyositis, bone or joint infection, or meningitis, but excluding pneumonia) |
| Chronic herpes simplex infection (orolabial or cutaneous of more than 1 month's duration or visceral at any site) |
| Esophageal candidiasis (or candidiasis of trachea, bronchi, or lungs) |
| Extrapulmonary tuberculosis |
| Kaposi sarcoma |
| Cytomegalovirus infection – Retinitis or cytomegalovirus infection affecting another organ, with onset at age older than 1 month |
| Central nervous system toxoplasmosis (after 1 month of life) |
| Extrapulmonary cryptococcosis (including meningitis) |
| HIV encephalopathy |
| Disseminated endemic mycosis (coccidiomycosis or histoplasmosis) |
| Disseminated nontuberculous mycobacterial infection |
| Chronic cryptosporidiosis (with diarrhea) |
| Chronic isosporiasis |
| Cerebral or B cell non-Hodgkin lymphoma |
| Progressive multifocal leukoencephalopathy |
| Symptomatic HIV-associated nephropathy or HIV-associated cardiomyopathy |
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