Hans and Tally methods for determining cell of origin in diffuse large B cell lymphoma

The Hans algorithm and Tally method use immunohistochemical stains to predict the cell of origin (GCB versus ABC or non-GCB) for cases of diffuse large B cell lymphoma. Each is approximately 80% concordant with gene expression profile results.

DLBCL: diffuse large B cell lymphoma; GCB: germinal center B cell; ABC: activated B cell.

References:

Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004; 103:275.
Meyer PN, Fu K, Greiner TC, et al. Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B cell lymphoma treated with rituximab. J Clin Oncol 2011; 29:200.

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Hans and Tally methods for determining cell of origin in diffuse large B cell lymphoma