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Bacitracin and polymyxin B (ophthalmic): Drug information

Bacitracin and polymyxin B (ophthalmic): Drug information
(For additional information see "Bacitracin and polymyxin B (ophthalmic): Patient drug information" and see "Bacitracin and polymyxin B (ophthalmic): Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • AK-Poly-Bac [DSC];
  • Polycin
Pharmacologic Category
  • Antibiotic, Ophthalmic
Dosing: Adult
Superficial ocular infections

Superficial ocular infections: Ophthalmic: Apply a thin strip to affected eye(s) every 3 to 4 hours for 7 to 10 days.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Bacitracin and polymyxin B (ophthalmic): Pediatric drug information")

Conjunctivitis

Conjunctivitis: Limited data available: Infants, Children, and Adolescents: Ophthalmic: Apply to affected eye(s) 4 times daily (Giggliotti 1984; Wald 1997)

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. See individual agents. Frequency not defined.

Hypersensitivity: Anaphylaxis

Ophthalmic: Burning sensation of eyes, conjunctival erythema, eye pruritus, swelling of eye

Contraindications

Hypersensitivity to bacitracin, polymyxin B, or any component of the formulation

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Ointment, Ophthalmic:

Polycin: Bacitracin 500 units and polymyxin B 10,000 units per g (3.5 g)

Generic: Bacitracin 500 units and polymyxin B 10,000 units per g (3.5 g)

Ointment, Ophthalmic [preservative free]:

AK-Poly-Bac: Bacitracin 500 units and polymyxin B 10,000 units per g (3.5 g [DSC])

Generic Equivalent Available: US

Yes

Pricing: US

Ointment (Polycin Ophthalmic)

500-10000 units/g (per gram): $7.46

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Ophthalmic: For topical ophthalmic use only; apply directly to conjunctival sac; avoid gross contamination of ointment during application.

Administration: Pediatric

Ophthalmic: Wash hands before use; avoid contact of tube tip with skin or eye

Use: Labeled Indications

Superficial ocular infections: Treatment of superficial eye infections caused by susceptible organisms.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Animal reproduction studies have not been conducted with this combination.

Breastfeeding Considerations

It is not known if bacitracin or polymyxin B are excreted into breast milk. The manufacturer recommends that caution be exercised when administering to nursing women.

Mechanism of Action

See individual agents.

Pharmacokinetics (Adult Data Unless Noted)

See individual agents.

Absorption: Insignificant from intact skin or mucous membrane

  1. AK-Poly-Bac (bacitracin and polymyxin b) ointment [prescribing information]. Lake Forest, IL: Akorn Inc; July 2018.
  2. Gigliotti F, Hendley JO, Morgan J, Michaels R, Dickens M, Lohr J. Efficacy of topical antibiotic therapy in acute conjunctivitis in children. J Pediatr. 1984;104(4):623-636. [PubMed 6323667]
  3. Polycin (bacitracin and polymyxin b) ointment [prescribing information]. Locust Valley, NY: Fera Pharmaceuticals LLC; July 2014.
  4. Polycin ointment (bacitracin zinc and polymyxin b sulfate) [prescribing information]. Minneapolis, MN: Perrigo; November 2014.
  5. Wald ER. Conjunctivitis in infants and children. Pediatr Infect Dis J. 1997;16(2 suppl):S17-S20. [PubMed 9041623]
Topic 103448 Version 82.0

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