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Splenic marginal zone lymphoma prognostic model

Splenic marginal zone lymphoma prognostic model
Points Risk group Proportion of patients
(percent)
Five-year OS
(percent)
Cause-specific deaths
(percent)
0 Low risk 41 83 16
1 Intermediate risk 34 72 30
2 or 3 High risk 25 56 54
One point is given for each of the following characteristics present in the patient with splenic MZL, for a total score ranging from zero to three:
  • Hemoglobin <12 g/dL
  • Serum lactate dehydrogenase level greater than normal
  • Serum albumin level <3.5 g/dL
When applied to a study of long-term survival in 309 patients with splenic MZL diagnosed between 1989 and 2004, three risk groups and their corresponding five-year OS and cause-specific death rates were identified.
MZL: marginal zone lymphoma; OS: overall survival.
Reference:
  1. Arcaini L, Lazzarino M, Colombo N, et al. Splenic marginal zone lymphoma: a prognostic model for clinical use. Blood 2006; 107:4643.
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