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Methylcellulose: Drug information

Methylcellulose: Drug information
(For additional information see "Methylcellulose: Patient drug information" and see "Methylcellulose: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Citrucel [OTC];
  • FT Fiber Laxative [OTC];
  • GoodSense Fiber [OTC];
  • Soluble Fiber Therapy [OTC]
Pharmacologic Category
  • Fiber Supplement;
  • Laxative;
  • Laxative, Bulk-Producing
Dosing: Adult
Constipation

Constipation: Oral:

Citrucel tablet: Two caplets as needed up to 6 times/day; maximum: 12 caplets/day.

Citrucel powder: 2 g (1 heaping tablespoon) in 8 oz (240 mL) of cold water; increase as needed by 1 heaping tablespoon up to 3 times/day.

Citrucel powder (sugar free): 2 g (1 rounded tablespoon) in 8 oz (240 mL) of cold water; increase as needed by 1 rounded tablespoon up to 3 times/day.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Methylcellulose: Pediatric drug information")

Constipation, occasional

Constipation, occasional:

Note: Ensure adequate liquid intake. Use of fiber (either dietary or supplemental) has not shown efficacy in pediatric patients for treatment of constipation, and the NASPGHAN guidelines do not recommend the use of fiber supplements (Ref).

Children 6 to <12 years:

Citrucel tablet: Oral: 1 caplet (500 mg fiber); may increase as needed up to 6 doses/day; maximum daily dose: 6 caplets (3,000 mg fiber)/day.

Citrucel powder: Oral: 21/2 level teaspoons (~1,667 mg fiber); may increase dose as needed by 21/2 level teaspoons up to 3 doses/day.

Children ≥12 years and Adolescents:

Citrucel tablet: Oral: 2 caplets (1,000 mg fiber) may increase as needed up to 6 doses/day; maximum daily dose: 12 caplets (6,000 mg fiber)/day.

Citrucel powder: Oral: 1 heaping tablespoon (2,000 mg fiber); may increase dose as needed by 1 heaping tablespoon up to 3 doses/day.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Adverse Reactions

There are no adverse reactions listed in the manufacturer's labeling.

Warnings/Precautions

Dosage form specific issues:

• Phenylalanine: Some products may contain phenylalanine.

Other warnings/precautions:

• Self-medication (OTC use): Prior to self-medication, patients should contact health care provider if they have abdominal pain, nausea, vomiting, or a sudden change in bowel habits lasting 2 weeks. Patients should stop use and call health care provider immediately if rectal bleeding, constipation lasting >7 days, chest pain, vomiting, difficulty breathing or swallowing occurs, or if no bowel movement after use. All doses must be taken with 8 ounces (240 mL) of water to prevent choking; patients who have difficulty swallowing should not use. Do not use for longer than 1 week unless directed by health care provider.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Powder, Oral:

Citrucel: (454 g, 850 g)

Citrucel: (479 g, 907 g, 1191 g) [gluten free, sugar free; orange flavor]

Soluble Fiber Therapy: (454 g)

Tablet, Oral:

Citrucel: 500 mg [contains fd&c yellow #6(sunset yellow)alumin lake]

FT Fiber Laxative: 500 mg [gluten free; contains fd&c yellow #6(sunset yellow)alumin lake]

GoodSense Fiber: 500 mg [contains fd&c yellow #6(sunset yellow)alumin lake]

Generic Equivalent Available: US

May be product dependent

Pricing: US

Tablets (Citrucel Oral)

500 mg (per each): $0.14

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Oral:

Tablet: Administer each dose with 8 ounces (240 mL) of water or other liquid to prevent choking.

Powder: Mix dose with ≥8 oz (240 mL) of water or other liquid; stir briskly until completely dissolved and drink immediately. Drinking an additional glass of water or other fluids is recommended.

Administration: Pediatric

Oral:

Caplet: Administer each dose with ≥240 mL (8 ounces) of water or other liquid to prevent choking.

Powder: Mix dose with ≥240 mL (8 ounces) of water or other liquid; stir briskly until completely dissolved and drink immediately. Drinking an additional glass of water or other fluids is recommended.

Use: Labeled Indications

Constipation: Adjunct in treatment of constipation and to help restore and maintain regularity.

Medication Safety Issues
Sound-alike/look-alike issues:

Citrucel may be confused with Citracal

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Dichlorphenamide: Laxatives may enhance the hypokalemic effect of Dichlorphenamide. Risk C: Monitor therapy

Pregnancy Considerations

When administered with adequate fluids, use is considered safe for the treatment of occasional constipation during pregnancy (Wald 2003).

Dietary Considerations

Some products may contain phenylalanine, potassium, and/or sodium.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AU) Australia: Cellulone;
  • (GB) United Kingdom: Cellucon;
  • (IE) Ireland: Celevac;
  • (KR) Korea, Republic of: Lacthycell;
  • (PR) Puerto Rico: Citrucel | Mirafiber;
  • (VE) Venezuela, Bolivarian Republic of: Fibracel
  1. Citrucel (methylcellulose) caplets [prescribing information]. Warren, NJ: GlaxoSmithKline; no date.
  2. Citrucel (methylcellulose) powder [prescribing information]. Moon Township, PA: GlaxoSmithKline; September 2015.
  3. Citrucel (methylcellulose) sugar free powder [prescribing information]. Warren, NJ: GlaxoSmithKline; no date.
  4. Citrucel (methylcellulose) tablet [prescribing information]. Warren, NJ: GlaxoSmithKline; January 2017.
  5. CVS Health Soluble Fiber Therapy (methylcellulose) powder [prescribing information]. Woonsocket, RI: GlaxoSmithKline; September 2016.
  6. Fiber Therapy (methylcellulose) powder [prescribing information]. Livonia, MI: Major Pharmaceuticals; August 2012.
  7. Sunmark Fiber Laxative (methylcellulose) tablet [prescribing information]. San Francisco, CA: McKesson; September 2012.
  8. Tabbers MM, DiLorenzo C, Berger MY, et al; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; North American Society for Pediatric Gastroenterology. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58(2):258-274. doi:10.1097/MPG.0000000000000266 [PubMed 24345831]
  9. Wald A, "Constipation, Diarrhea, and Symptomatic Hemorrhoids During Pregnancy," Gastroenterol Clin North Am, 2003, 32(1):309-22. [PubMed 12635420]
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