T cell subsets

Designation	Induced by	Transcription factor	Produces
Th1	IL-12	T-beta	IFN-gamma TNF-alpha
Th2	IL-4	GATA-3	IL-4 IL-5 IL-6 IL-13
Th3	IL-4 IL-10 TGF-beta	FoxP3	TGF-beta
Th9	IL-4 TGF-beta	GATA-3 IRF-4 PU.1	IL-9
Th17	IL-1 beta IL-6 IL-21 IL-23	ROR-gammaT	IL-17
Th22	IL-6 IL-12 IL-23 TNF-alpha		IL-22
Treg	IL-2 TGF-beta	FoxP3	IL-10 TGF-beta
Tfh	IL-12 IL-23 TGF-beta	Bcl-6	IL-21 B cell help

Th: T helper; IL: interleukin; IFN: interferon; TNF: tumor necrosis factor; GATA: GATA-binding protein (GATA is a deoxyribonucleic acid [DNA] sequence); TGF: transforming growth factor; IRF: interferon regulatory factor; PU.1: an oncogene and transcription factor that binds to the PU-box, a purine-rich DNA sequence; ROR: regulator of reprogramming; Treg: regulatory T cell; Tfh: T follicular helper cell; Bcl: B cell lymphoma.

Graphic 101256 Version 2.0

خرید پکیج

T cell subsets