Suggested classification of Clostridioides difficile infection in children*

Suggested classification of Clostridioides difficile infection in children*

Mild	Moderate	Severe	Fulminant
Afebrile Diarrhea (without systemic findings)	Fever Profuse diarrhea Abdominal pain	Fever Profuse diarrhea Abdominal pain and tenderness Abdominal distention Leukocytosis (white blood cells >15,000 cells/microL) Elevated age-adjusted creatinine level Pseudomembranous colitis	Hypotension Shock Ileus Toxic megacolon

* There is no consensus definition of severe C. difficile infection in children. Determination of disease severity should be guided by clinician judgment.

Graphic 100705 Version 7.0

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