ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Laboratory testing in chronic granulomatous disease (CGD)

Laboratory testing in chronic granulomatous disease (CGD)
Testing of the ability of neutrophils to generate superoxide is used in the diagnosis of chronic granulomatous disease (CGD). This testing can be done using flow cytometry to detect the ability to reduce dihydrorhodamine (DHR) to its fluorescent form, or the ability to reduce nitroblue tetrazolium (NBT), which is assayed on a slide. Normally functioning neutrophils will generate high fluorescence intensity from DHR (blue bar in flow cytometry panels) and high levels of reduced NBT (blue cytoplasm in cells on the slide). Refer to UpToDate topics on CGD and laboratory testing for disorders of neutrophil function for further details.
PMA: phorbol myristate acetate (used to stimulate neutrophils); DHR: dihyrdrorhodamine; NBT: nitroblue tetrazolium.
Courtesy of Thomas Coates, MD
Graphic 100539 Version 1.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟