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Flow cytometry for CD11b in leukocyte adhesion deficiency I (LAD-I).

Flow cytometry for CD11b in leukocyte adhesion deficiency I (LAD-I).
Flow cytometry on stimulated neutrophils from an individual with normal neutrophil function, an LAD-I carrier (heterozygote), and moderate and severe LAD-I, showing CD11b fluorescence (solid line) versus a nonspecific control (dashed line).  Percentages refer to the amount of fluorescence intensity relative to the normal control.
Adapted from: Dinauer MC, Coates TD. Disorders of phagocyte function. In: Hematology: Basic Principles and Practice, 6th ed, Hoffman R, Benz EJ Jr, Silberstein LE (Eds), Elsevier, Philadelphia 2012. p.655. Illustration used with the permission of Elsevier Inc. All rights reserved.
Graphic 100524 Version 1.0

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