PSA: prostate-specific antigen; ADT: androgen deprivation therapy. * A PSA rise of 2 ng/mL or more above the nadir PSA (Phoenix criteria). ¶ The staging evaluation may include computed tomography (CT) of the abdomen and pelvis, bone scan, and/or positron emission tomography (PET) scan using one of the more sensitive prostate cancer-specific radiotracers (eg, F-18 fluciclovine [Axumin] or gallium Ga-68 PSMA-11). Δ Factors to consider include age, comorbidity, PSA kinetics, Gleason grade, and prognostic factors at original diagnosis. ◊ Options include radical prostatectomy, cryotherapy, brachytherapy.
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