Version July 2025
Note: Oral OTC supplements containing vitamin A may express the amount as mcg (retinol activity equivalents [RAE]) instead of (or in addition to) units; 1 unit = 0.3 mcg (RAE) = 0.3 mcg retinol (Ref).
Dietary supplement: Oral: One tablet or capsule daily; dosage may vary depending on dosage form; consult specific product labeling.
Vitamin A deficiency, treatment:
Manufacturer recommendation: IM: Note: IM route is indicated when oral administration is not feasible or when absorption is insufficient (malabsorption syndrome): 100,000 units (30,000 mcg)/day for 3 days, followed by 50,000 units (15,000 mcg)/day for 2 weeks.
Note: Follow-up therapy with an oral therapeutic multivitamin (containing additional vitamin A) is recommended: Oral: 10,000 to 20,000 units (3,000 to 6,000 mcg)/day for 2 months.
Vitamin A deficiency, prophylaxis in patients at high risk for deficiency (off-label dose) (eg, persons living in developing areas of the world where deficiency is a public health problem, especially persons with severe infectious disease or malnutrition): Oral:
Adults: 200,000 units (60,000 mcg)/dose every 6 months (Ref)
Pregnant females: Maximum 10,000 units (3,000 mcg)/day or 25,000 units (7,500 mcg) once weekly. Administer for a minimum of 12 weeks during pregnancy or until delivery (Ref)
Postpartum females: 200,000 units (60,000 mcg) at delivery or within 8 weeks of delivery (Ref)
Xerophthalmia, treatment (off-label use): Oral:
Adults (except females of reproductive age): 200,000 units (60,000 mcg) once daily for 2 days; repeat with single dose after 2 weeks (Ref).
Females of reproductive age (Ref):
With night blindness or Bitot's spots (less severe xerophthalmia): 5,000 to 10,000 units (1,500 to 3,000 mcg)/day (maximum 10,000 units [3,000 mcg]/day) or ≤25,000 units (≤7,500 mcg) once weekly for ≥4 weeks.
Severe xerophthalmia: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
(For additional information see "Vitamin A: Pediatric drug information")
Note: Vitamin A products may express the amount as mcg (retinol activity equivalents [RAE]) instead of (or in addition to) units; 1 unit retinol = 0.3 mcg RAE = 0.3 mcg retinol (Ref).
Cystic fibrosis supplementation: Note: Typically administered as part of a fixed dosage product with other fat-soluble vitamins (eg, ADEK); however, some patients may require higher doses based on condition (CF liver disease (Ref)); doses presented are in addition to usual RDA for age.
Infants: Oral: 1,500 units/day (450 mcg RAE/day) (Ref).
Children 1 to 3 years: Oral: 5,000 units/day (1,500 mcg RAE/day) (Ref).
Children 4 to 8 years: Oral: 5,000 to 10,000 units/day (1,500 to 3,000 mcg RAE/day) (Ref).
Children ≥9 years and Adolescents: Oral: 10,000 units/day (3,000 mcg RAE/day) (Ref); some data suggest that dose should be individualized based on patient serum concentrations. Based on current US recommendations, some available multivitamin products may be excessive based on patient's needs, particularly in preadolescent patients (Ref).
Malabsorption (eg, cholestasis, biliary atresia); supplementation: Limited data available: Children and Adolescents: Note: Specific dose should be based on serum markers and clinical condition; dose should be individualized: Oral: 5,000 to 15,000 units/day (1,500 to 4,500 mcg RAE/day) of water miscible product (eg, Aquasol A); begin at low end of the range for younger patients (Ref).
Measles infection, supplementation: Limited data available:
Note: Vitamin A is not effective for prevention of measles. In patients with confirmed measles diagnosis, vitamin A may be beneficial and is recommended for use (Ref).
Infants <6 months: Oral: 50,000 units/day (15,000 mcg RAE/day) for 2 days (Ref).
Infants 6 to 11 months: Oral: 100,000 units/day (30,000 mcg RAE/day) for 2 days (Ref).
Infants ≥12 months and Children: Oral: 200,000 units/day (60,000 mcg RAE/day) for 2 days (Ref).
Note: If severe malnutrition or ophthalmologic evidence of vitamin A deficiency is present, administer a third dose 2 to 6 weeks after the second dose (Ref).
Vitamin A deficiency; prevention for geographical at-risk populations: Note: Supplementation recommended in areas where vitamin A deficiency is a public health problem, including local prevalence of night blindness ≥1% in ages 24 to 59 months or prevalence of serum retinol ≤0.7 mmol/L is ≥20% in ages 6 to 59 months (Ref).
Infants ≥6 months: Oral: 100,000 units/dose (30,000 mcg RAE/dose) administered once.
Children <5 years: Oral: 200,000 units/dose (60,000 mcg RAE/dose) administered as a single dose every 4 to 6 months.
Vitamin A deficiency, treatment:
Initial:
Infants: IM: 7,500 to 15,000 units/dose (2,250 to 4,500 mcg RAE/dose) once daily for 10 days followed by oral supplementation.
Children 1 to 8 years: IM: 17,500 to 35,000 units/dose (5,250 to 10,500 mcg RAE/dose) once daily for 10 days followed by oral supplementation.
Children >8 years and Adolescents: IM: 100,000 units/dose (30,000 mcg RAE/dose) once daily for 3 days; then 50,000 units/dose (15,000 mcg RAE/dose) once daily for 14 days followed by oral supplementation.
Maintenance oral supplementation: After completion of an IM course to correct deficiency, patient should continue on an oral supplementation for 2 months with a multivitamin preparation that contains: Infants and children <8 years: 5,000 to 10,000 units/day (1,500 to 3,000 mcg RAE/day); children ≥8 years and adolescents: 10,000 to 20,000 units/day (3,000 to 6,000 mcg RAE/day).
Xerophthalmia: Limited data available (Ref):
Infants <6 months: Oral: 50,000 units (15,000 mcg RAE) administered as a single dose; repeat the next day and again after at least 2 weeks for a total of 3 doses.
Infants 6 to 12 months: Oral: 100,000 units (30,000 mcg RAE) administered as a single dose; repeat the next day and again after at least 2 weeks for a total of 3 doses.
Children and Adolescents: Oral: 200,000 units (60,000 mcg RAE) administered as a single dose; repeat the next day and again after at least 2 weeks for a total of 3 doses.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions are derived from product labeling unless otherwise specified.
Postmarketing:
Hypersensitivity: Hypersensitivity reaction, nonimmune anaphylaxis
Nervous system: Intracranial hypertension (Tan 2019)
Hypersensitivity to vitamin A or any component of the formulation; hypervitaminosis A; pregnancy (dose exceeding RDA); intravenous administration of Aquasol A
Dosage form specific issues:
• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer's labeling.
• Parenteral vitamin A: In low birth weight infants, polysorbates have been associated with thrombocytopenia, renal dysfunction, hepatomegaly, cholestasis, ascites, hypotension, and metabolic acidosis (E-Ferol syndrome).
• Polysorbate 80: Some dosage forms may contain polysorbate 80 (also known as Tweens). Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals (Isaksson 2002; Lucente 2000; Shelley 1995). Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 (Alade 1986; CDC 1984). See manufacturer's labeling.
Other warnings/precautions:
• Appropriate use: Evaluate other sources of vitamin A while receiving this product; patients receiving >25,000 units/day should be closely monitored for toxicity.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule, Oral:
A-25: 7.5 MG (25000 UT)
True Vitamin A: 8000 units, 10,000 units
Vitamin A Fish: 2250 MCG (7500 UT)
Generic: 3 MG (10000 UT)
Capsule, Oral [preservative free]:
Generic: 2400 MCG (8000 UT)
Cream, External:
Gordons-Vite A: 100,000 units/g (75 g, 120 g, 480 g, 2400 g)
Liquid, Oral:
Generic: 1500 mcg/mL (60 mL)
Lotion, External:
Gordons-Vite A: 100,000 units (120 mL, 3840 mL)
Solution, Intramuscular:
Aquasol A: 15 mg/mL (2 mL [DSC]); 50,000 units/mL (2 mL) [contains chlorobutanol (chlorobutol), polysorbate 80]
Tablet, Oral:
Generic: 3 MG (10000 UT), 4.5 MG (15000 UT)
May be product dependent
Capsules (Vitamin A Fish Oral)
2250 MCG(7500 UT) (per each): $0.03
Capsules (Vitamin A Oral)
3 MG(10000 UT) (per each): $0.03 - $0.05
2400 MCG(8000 UT) (per each): $0.04
Cream (Gordons-Vite A External)
100000 units/g (per gram): $0.17
Liquid (Vitamin A Oral)
1500 mcg/mL (per mL): $8.25
Lotion (Gordons-Vite A External)
100000 unit (per mL): $0.07
Solution (Aquasol A Intramuscular)
50000 units/mL (per mL): $431.25
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
IM: Administer as an intramuscular injection. Note: IV administration is contraindicated.
Oral: Administer with food.
Oral: Administer with food or milk; for infants and children <24 months of age, capsules may be cut open and contents squeezed into the mouth (Ref).
Parenteral: For IM use only; for neonatal patients, a 0.3 mL syringe and 29-gauge needle should be used for IM dose administration (Ref).
Treatment of vitamin A deficiency; parenteral (IM) route is indicated when oral administration is not feasible or when absorption is insufficient (malabsorption syndrome); dietary supplement when vitamin A intake may be inadequate (OTC).
Xerophthalmia caused by vitamin A deficiency
Aquasol may be confused with Anusol
The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drugs (contraindicated in pregnancy [doses exceeding RDA]) which have a heightened risk of causing significant patient harm when used in error (High-Alert Medications in Community/Ambulatory Care Settings).
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Bexarotene (Topical): Vitamin A may increase adverse/toxic effects of Bexarotene (Topical). Management: Limit doses of vitamin A to 5,000 units per day if combined with topical bexarotene. Risk D: Consider Therapy Modification
Orlistat: May decrease absorption of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or 2 hours after the administration of orlistat. Avoid concomitant administration due to the risk of impaired vitamin absorption. Risk D: Consider Therapy Modification
Retinoic Acid Derivatives: Vitamin A may increase adverse/toxic effects of Retinoic Acid Derivatives. Risk X: Avoid
Excessive ethanol intake depletes the liver of vitamin A and may enhance vitamin A toxicity (IOM 2000)
Doses greater than the RDA are contraindicated in women who may become pregnant. High doses are used in some areas of the world for supplementation where deficiency is a public health problem (eg, to prevent night blindness); however, single doses >25,000 units should be avoided within 60 days of conception. High-dose supplementation is otherwise not recommended as part of routine antenatal care (WHO 2011c).
Excess vitamin A during pregnancy may cause craniofacial malformations, as well as CNS, heart, and thymus abnormalities. Maternal vitamin A deficiency also causes adverse effects in the fetus, and vitamin A requirements are increased in pregnant women (IOM 2000). The manufacturer notes that the safety of doses >6,000 units/day in pregnant women has not been established and doses greater than the RDA are contraindicated in pregnant women.
Vitamin A requirements are increased in breastfeeding women (IOM 2000). High-dose supplementation (eg, doses higher than the RDA) is not recommended in otherwise healthy women who receive adequate nutrition (WHO 2011b).
Dairy products, fish, and liver are common dietary sources of vitamin A; broccoli, cantaloupe, carrots, peas, spinach, and squash are sources of beta-carotene (which is converted to vitamin A) (IOM 2000)
Dietary reference Intake (presented as retinol activity equivalent [RAE]) (IOM 2001):
1 to 6 months: Adequate intake: 400 mcg/day (1,330 units/day)
7 to 12 months: Adequate intake: 500 mcg/day (1,670 units/day)
1 to 3 years: RDA: 300 mcg/day (1,000 units/day)
4 to 8 years: RDA: 400 mcg/day (1,330 units/day)
9 to 13 years: RDA: 600 mcg/day (2,000 units/day)
>13 years: RDA: Females: 700 mcg/day (2,330 units/day); Males: 900 mcg/day (3,000 units/day)
Pregnancy: RDA: 14 to 18 years: 750 mcg/day (2,500 units/day); ≥19 years: 770 mcg/day (2,560 units/day)
Lactation: RDA: 14 to 18 years: 1,200 mcg/day (4,000 units/day); ≥19 years: 1,300 mcg/day (4,330 units/day)
Serum retinol
Vitamin A is a fat soluble vitamin needed for visual adaptation to darkness, maintenance of epithelial cells, immune function and embryonic development.
Absorption: Vitamin A in dosages not exceeding physiologic replacement is well absorbed in the small intestine after oral administration; water miscible preparations are absorbed more rapidly than oil preparations; large oral doses, conditions of fat malabsorption, low protein intake, or hepatic or pancreatic disease reduces oral absorption
Distribution: Large amounts concentrate for storage in the liver
Metabolism: Converted in the small intestine to retinol and further metabolized in the liver; conjugated with glucuronide; undergoes enterohepatic recirculation
Excretion: Feces; urine
