JAMA Dermatology

Importance A previous single-center study observed fewer excisions, lower health care costs, thinner melanomas, and better quality of life when surveillance of high-risk patients was conducted in a melanoma dermatology clinic with a structured surveillance protocol involving full-body examinations every 6 months aided by total-body photography (TBP) and sequential digital dermoscopy imaging (SDDI).

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Association of Treatment Facility Characteristics With Overall Survival After Mohs Micrographic Surgery for T1a-T2a Invasive Melanoma

Shayan Cheraghlou, MD; Sean R. Christensen, MD, PhD; David J. Leffell, MD; et al.

doi : 10.1001/jamadermatol.2021.0023

JAMA Dermatol. 2021;157(5):531-539

Importance Early-stage melanoma, among the most common cancers in the US, is typically treated with wide local excision. However, recent advances in immunohistochemistry have led to an increasing number of these cases being excised via Mohs micrographic surgery (MMS). Although studies of resections for other cancers have reported that facility-level factors are associated with patient outcomes, it is not yet established how these factors may affect outcomes for patients treated with Mohs micrographic surgery.

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Association Between Surgical Margins Larger Than 1 cm and Overall Survival in Patients With Merkel Cell Carcinoma

Neal Andruska, MD, PhD; Benjamin W. Fischer-Valuck, MD; Lily Mahapatra, MD, PhD; et al.

doi : 10.1001/jamadermatol.2021.0247

JAMA Dermatol. 2021;157(5):540-548

Importance Current recommendations regarding the size of local excision (LE) margins for Merkel cell carcinoma (MCC) have not been well established.

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Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and MelanomaA Systematic Review and Meta-analysis

Megan Lam, BSc; Jie Wei Zhu, BHSc; Mina Tadrous, PharmD, PhD; et al.

doi : 10.1001/jamadermatol.2021.0345

JAMA Dermatol. 2021;157(5):549-558

Importance Topical calcineurin inhibitors (TCIs) are commonly used as second-line treatment for atopic dermatitis. In 2006, the US Food and Drug Administration issued a black box warning against TCI use, citing data from case reports and animal studies indicating a potential risk of cancer.

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Ten-Year Follow-up of Persons With Sun-Damaged Skin Associated With Subsequent Development of Cutaneous Squamous Cell Carcinoma

Shabnam Madani, MD; Sangeeta Marwaha, MD; Jennifer R. Dusendang, MPH; et al.

doi : 10.1001/jamadermatol.2021.0372

JAMA Dermatol. 2021;157(5):559-565

Importance Risk of cutaneous squamous cell carcinoma (cSCC) after the diagnosis of actinic keratosis (AK) has not been studied during long follow-up periods.

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Clinical Features, Prognostic Factors, and Treatment Interventions for Ulceration in Patients With Infantile Hemangioma

Esteban Fern?ndez Faith, MD; Sonal Shah, MD; Patricia M. Witman, MD; et al.

doi : 10.1001/jamadermatol.2021.0469

JAMA Dermatol. 2021;157(5):566-572

Importance Ulceration is a common complication of infantile hemangioma (IH), which leads to substantial morbidity. Ulceration in IH has not been systematically studied since the advent of ?-blocker therapy for IH.

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Perceived Usefulness and Recall of Sunscreen Label Information by Consumers

Calvin P. Tribby, PhD; Anne K. Julian, PhD; Frank M. Perna, EdD, PhD

doi : 10.1001/jamadermatol.2020.5394

JAMA Dermatol. 2021;157(5):573-576

Importance In February 2019, the US Food and Drug Administration issued a proposed rule (84 FR 6204), an amendment to the Sunscreen Innovation Act of 2014, that would require listing active ingredients on the principal display panel of sunscreens to allow consumers to “more readily compare products and either select or avoid a given product accordingly.”

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Patterns of Cutaneous and Noncutaneous Immune-Related Adverse Events Among Patients With Advanced Cancer

Leah L. Thompson, BA; Nira A. Krasnow, BS; Michael S. Chang, BA; et al.

doi : 10.1001/jamadermatol.2021.0326

JAMA Dermatol. 2021;157(5):577-582

Importance Cutaneous immune-related adverse events (cirAEs) are some of the earliest toxic reactions to emerge following immune-checkpoint inhibitor (ICI) initiation. As an early indicator of robust inflammatory response, cirAEs may be associated with patterns of immune-mediated toxic effects, but associations between these events and noncutaneous immune-related adverse events (irAEs) remain underexplored.

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Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative StageA Randomized Clinical Trial

Fania Z. Mu?oz-Garza, MD; M?nica R?os; Esther Roé-Crespo, MD; et al.

doi : 10.1001/jamadermatol.2021.0596

JAMA Dermatol. 2021;157(5):583-587

Importance Treatment of infantile hemangioma (IH) with topical timolol in the first 2 months of life (early proliferative phase) may prevent further growth and the need for treatment with oral propranolol. To our knowledge, no studies have determined whether beginning early treatment with timolol for IH is better than in other proliferative stages.

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