Journal of Crohn's and Colitis

Michel Adamina, Roger Feakins, Marietta Iacucci, Antonino Spinelli, Rosanna Cannatelli, André D’Hoore, Ann Driessen, Konstantinos Katsanos, Aart Mookhoek, P?r Myrelid, Gianluca Pellino, Georgios Peros, Gian Eugenio Tontini, Monika Tripathi, Henit Yanai, Magali Svrcek

doi : 10.1093/ecco-jcc/jjab011

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1089–1105

Diagnosis and management of inflammatory bowel diseases [IBD] requires a lifelong multidisciplinary approach. The quality of medical reporting is crucial in this context. The present topical review addresses the need for optimised reporting in endoscopy, surgery, and histopathology.

خرید پکیج و مشاهده آنلاین مقاله

Hypnotherapy for Irritable Bowel Syndrome-Type Symptoms in Patients with Quiescent Inflammatory Bowel Disease: A Randomized, Controlled Trial

Daniël R Hoekman, Arine M Vlieger, Pieter C Stokkers, Nofel Mahhmod, Svend Rietdijk, Nanne K de Boer, Tim G de Meij, Carla Frankenhuis, Geert R D’Haens, Marc A Benninga

doi : 10.1093/ecco-jcc/jjaa241

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1106–1113

Many inflammatory bowel disease [IBD] patients in remission have persisting symptoms, compatible with irritable bowel syndrome [IBS-type symptoms]. We aimed to compare the effectiveness of gut-directed hypnotherapy vs standard medical treatment [SMT] for IBS-type symptoms in IBD patients.

خرید پکیج و مشاهده آنلاین مقاله

End of Induction Patient-reported Outcomes Predict Clinical Remission but Not Endoscopic Remission in Crohn’s Disease

Emily C L Wong, Elisa Buffone, So Jeong Lee, Parambir S Dulai, John K Marshall, Walter Reinisch, Neeraj Narula

doi : 10.1093/ecco-jcc/jjaa242

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1114–1119

It is unclear whether early symptom improvement in Crohn’s disease [CD] provides any prognostic information for patients long-term. This paper aims to investigate the relationship between early patient-reported outcomes [PROs] after completion of induction of infliximab, and their relationship with long-term clinical remission [CR] and endoscopic remission [ER].

خرید پکیج و مشاهده آنلاین مقاله

Long-Term Efficacy and Safety of Ozanimod in Moderately to Severely Active Ulcerative Colitis: Results From the Open-Label Extension of the Randomized, Phase 2 TOUCHSTONE Study

William J Sandborn, Brian G Feagan, Stephen Hanauer, Severine Vermeire, Subrata Ghosh, Wenzhong J Liu, AnnKatrin Petersen, Lorna Charles, Vivian Huang, Keith Usiskin, Douglas C Wolf, Geert D’Haens

doi : 10.1093/ecco-jcc/jjab012

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1120–1129

This analysis examined the long-term safety and efficacy of ozanimod in patients with moderately to severely active ulcerative colitis [UC] with ??4 years of follow-up in the phase 2 TOUCHSTONE open-label extension [OLE].

خرید پکیج و مشاهده آنلاین مقاله

Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomised RIVETING Trial

Séverine Vermeire, Chinyu Su, Nervin Lawendy, Taku Kobayashi, William J Sandborn, David T Rubin, Irene Modesto, Sean Gardiner, Nicole Kulisek, Haiying Zhang, Wenjin Wang, Julian Panés

doi : 10.1093/ecco-jcc/jjaa249

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1130–1141

Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. We present primary completion analysis from RIVETING, an ongoing, double-blind, randomised, parallel-group trial evaluating efficacy and safety of tofacitinib dose reduction to 5 mg twice daily [BID] versus remaining on 10 mg BID in patients in stable remission on tofacitinib 10 mg BID maintenance therapy.

خرید پکیج و مشاهده آنلاین مقاله

Hypoalbuminaemia, Not Biologic Exposure, Is Associated with Postoperative Complications in Crohn’s Disease Patients Undergoing Ileocolic Resection

Ravi S Shah, Salam Bachour, Xue Jia, Stefan D Holubar, Tracy L Hull, Jean-Paul Achkar, Jessica Philpott, Taha Qazi, Florian Rieder, Benjamin L Cohen, Miguel D Regueiro, Amy L Lightner, Benjamin H Click

doi : 10.1093/ecco-jcc/jjaa268

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1142–1151

There are limited data on the postoperative outcomes in Crohn’s disease patients exposed to preoperative ustekinumab or vedolizumab. We hypothesised that preoperative biologic use in Crohn’s disease is not associated with postoperative complications after ileocolic resection.

خرید پکیج و مشاهده آنلاین مقاله

Ability of Pelvic Magnetic Resonance Imaging to Predict Clinical Course of Perianal Fistula in Paediatric Crohn’s Disease Patients

Pyeong Hwa Kim, Seo Hee Kim, Young Ah Cho, Hee Mang Yoon, Jin Seong Lee, Ah Young Jung, Seak Hee Oh, Dae Yeon Kim, Jung-Man Namgoong, Kyung Mo Kim

doi : 10.1093/ecco-jcc/jjab004

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1152–1160

Evidence is limited regarding clinical course and magnetic resonance imaging [MRI] features of perianal fistula [PAF] in Korean children with Crohn’s disease [CD]. We investigated MRI features of PAF and associations with long-term outcomes.

خرید پکیج و مشاهده آنلاین مقاله

Degree of Creeping Fat Assessed by Computed Tomography Enterography is Associated with Intestinal Fibrotic Stricture in Patients with Crohn’s Disease: A Potentially Novel Mesenteric Creeping Fat Index

Xue-Hua Li, Shi-Ting Feng, Qing-Hua Cao, J Calvin Coffey, Mark E Baker, Li Huang, Zhuang-Nian Fang, Yun Qiu, Bao-Lan Lu, Zhi-Hui Chen, Yi Li, Dominik Bettenworth, Marietta Iacucci, Can-Hui Sun, Subrata Ghosh, Florian Rieder, Min-Hu Chen, Zi-Ping Li, Ren Mao

doi : 10.1093/ecco-jcc/jjab005

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1161–1173

Emerging evidence points to a link between creeping fat and the pathogenesis of Crohn’s disease [CD]. Non-invasive assessment of the severity of creeping fat on cross-sectional imaging modality has seldom been investigated. This study aimed to develop and characterize a novel mesenteric creeping fat index [MCFI] based on computed tomography [CT] in CD patients.

خرید پکیج و مشاهده آنلاین مقاله

Course of Disease in Patients with Microscopic Colitis: A European Prospective Incident Cohort Study

Bas P M Verhaegh, Andreas Münch, Danila Guagnozzi, Signe Wildt, Wojciech Cebula, Andreea R Diac, Fernando Fern?ndez-Ba?ares, Magid A R Al-Khalaf, Natalia Pedersen, Juozas Kupcinskas, Johan Bohr, Gilles Macaigne, Alfredo J Lucendo, Ivan Lyutakov, Gian-Eugenio Tontini, Flavia Pig?, Evangelos Russo, Henrik Hjortswang, Stephan Miehlke, Lars K Munck

doi : 10.1093/ecco-jcc/jjab007

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1174–1183

The disease course of microscopic colitis [MC] is considered chronic but benign. However, this assumption is based on mainly retrospective studies, reporting on incomplete follow-up of selective cohorts. Systematic, prospective and unbiased data to inform patients and healthcare professionals on the expected course of the disease and real-life response to therapy are warranted.

خرید پکیج و مشاهده آنلاین مقاله

Efficacy of Oral, Topical, or Combined Oral and Topical 5-Aminosalicylates, in Ulcerative Colitis: Systematic Review and Network Meta-analysis

Brigida Barberio, Jonathan P Segal, M Nabil Quraishi, Christopher J Black, Edoardo V Savarino, Alexander C Ford

doi : 10.1093/ecco-jcc/jjab010

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1184–1196

5-Aminosalicylates [5-ASAs] are the mainstay of treatment for ulcerative colitis [UC]. The optimum preparation, dose, and route of administration for UC remain unclear. We conducted a network meta-analysis to examine this issue.

خرید پکیج و مشاهده آنلاین مقاله

Modulation of the Gut Microbiota-farnesoid X Receptor Axis Improves Deoxycholic Acid-induced Intestinal Inflammation in Mice

Mengque Xu, Yuqin Shen, Mengsha Cen, Yubin Zhu, Fangli Cheng, Linlin Tang, Xia Zheng, John J Kim, Ning Dai, Weiling Hu

doi : 10.1093/ecco-jcc/jjab003

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1197–1210

Inflammatory bowel disease (IBD) is associated with gut dysbiosis and dysregulation of bile acid metabolism. A high luminal content of deoxycholic acid (DCA) with consumption of a Westernised diet is implicated in the pathogenesis of IBD. The aim of the study is to explore the role of intestinal microbiota and bile acid metabolism in mice with DCA-induced intestinal inflammation.

خرید پکیج و مشاهده آنلاین مقاله

Predicting Outcome in Acute Severe Colitis—Controversies in Clinical Practice in 2021

Vipin Gupta, Waled Mohsen, Thomas P Chapman, Jack Satsangi

doi : 10.1093/ecco-jcc/jjaa265

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1211–1221

Acute severe ulcerative colitis [ASUC] remains a common medical emergency, with 25% of patients with ulcerative colitis experiencing at least one event in their disease course. Despite advances in medical therapy, ASUC continues to be associated with considerable morbidity and mortality, with up to 30% of patients requiring colectomy during initial admission. Our aim was to review the current controversies and recent progress in risk stratification, prediction of outcome, and personalisation of care in ASUC. We re-assess the use of Truelove and Witts’ criteria, serum biomarkers, and the use of composite clinical indices in current clinical practice. We explore the potential for endoscopic prediction using defined validated indices for accurate and early prognostication, and the need to define outcome. We also consider the impact of the current COVID-19 pandemic. Finally, we discuss the current research agenda, including the application of new and emerging biomarkers coupled with multi-omics and the implications in management and optimisation of outcome. Research priorities for the prediction of outcome in acute severe colitis include the following.

خرید پکیج و مشاهده آنلاین مقاله

Organoid-based Models to Study the Role of Host-microbiota Interactions in IBD

Martina Poletti, Kaline Arnauts, Marc Ferrante, Tamas Korcsmaros

doi : 10.1093/ecco-jcc/jjaa257

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1222–1235

The gut microbiota appears to play a central role in health, and alterations in the gut microbiota are observed in both forms of inflammatory bowel disease [IBD], namely Crohn’s disease and ulcerative colitis. Yet, the mechanisms behind host-microbiota interactions in IBD, especially at the intestinal epithelial cell level, are not yet fully understood. Dissecting the role of host-microbiota interactions in disease onset and progression is pivotal, and requires representative models mimicking the gastrointestinal ecosystem, including the intestinal epithelium, the gut microbiota, and immune cells. New advancements in organoid microfluidics technology are facilitating the study of IBD-related microbial-epithelial cross-talk, and the discovery of novel microbial therapies. Here, we review different organoid-based ex vivo models that are currently available, and benchmark their suitability and limitations for specific research questions. Organoid applications, such as patient-derived organoid biobanks for microbial screening and ’omics technologies, are discussed, highlighting their potential to gain better mechanistic insights into disease mechanisms and eventually allow personalised medicine.

خرید پکیج و مشاهده آنلاین مقاله

Ustekinumab for Extra-intestinal Manifestations of Inflammatory Bowel Disease: A Systematic Literature Review

Lucas Guillo, Ferdinando D’Amico, Silvio Danese, Laurent Peyrin-Biroulet

doi : 10.1093/ecco-jcc/jjaa260

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1236–1243

Extra-intestinal manifestations [EIMs] are frequent in patients with inflammatory bowel diseases [IBD] and are challenging conditions to manage. Tumour necrosis factor alpha antagonists [anti-TNF?] are recognised as the primary therapeutic option. We aimed to summarise evidence on the efficacy of ustekinumab for the treatment of EIMs.

خرید پکیج و مشاهده آنلاین مقاله

Recurrent COVID-19 in a Patient With Ulcerative Colitis on Vedolizumab Therapy

Femke Crouwel, Petra Waaijenberg-Warmenhoven, Hans J C Buiter, Nanne K de Boer

doi : 10.1093/ecco-jcc/jjaa259

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Pages 1244–1245

خرید پکیج و مشاهده آنلاین مقاله

Association Between Statin Use and Inflammatory Bowel Diseases

Cong Dai, Min Jiang, Yu-hong Huang

doi : 10.1093/ecco-jcc/jjaa258

Journal of Crohn's and Colitis, Volume 15, Issue 7, July 2021, Page 1246

خرید پکیج و مشاهده آنلاین مقاله