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Piecing Together the Puzzle of 17q12–q21 Genetics, Immune Responses, and Wheeze
James E. Gern 1,2
doi : 10.1164/rccm.202201-0023ED
Volume 205, Issue 6 | March 15 2022
Strengthening the Epidemiological Evidence Linking Air Pollution and COVID-19
David M. Stieb 1,2
The Double-edged Sword of Reverse Triggering: Impact on the Diaphragm
Catherine S. Sassoon 1 and Jordi Mancebo 2
FocuSSced on the Target in Systemic Sclerosis–Interstitial Lung Disease: Another Arrow in the Quiver?
Scott M. Matson 1, Melissa Griffith 2, and Joyce S. Lee 2
Thrombospondin in the Puzzle of Bronchopulmonary Dysplasia
Shyamala Dakshinamurti 1,2
The Vanishing Rationale for the Race Adjustment in Pulmonary Function Test Interpretation
Neil W. Schluger
Predicting Weight-Loss Effects on Obstructive Sleep Apnea and Cardiometabolic Health: In Search of the Craniofacial “Holy Grail�
Craig L. Phillips 1,2, Elizabeth A. Cayanan 1, and Brendon J. Yee 1,3
A Good Fit versus One Size for All: Alternatives to Race in the Interpretation of Pulmonary Function Tests
Nirav R. Bhakta 1, and John R. Balmes 1,2
Stakeholder Research Priorities to Promote Implementation of Shared Decision-Making for Lung Cancer Screening: An American Thoracic Society and Veterans Affairs Health Services Research and Development Statement
Renda Soylemez Wiener , Anna M. Barker , Lisa Carter-Harris , Tanner J. Caverly , David A. Crocker , Angela Denietolis , Charlotte Doherty , Angela Fagerlin , Mary Gallagher-Seaman , Michael K. Gould , Paul K. J. Han , Abigail N. Herbst , Mayuko Ito Fukunaga , Megan B. McCullough , Danielle A. Miano , Samantha L. Quaife , Christopher G. Slatore , and Gemmae M. Fix ;
Cystic Fibrosis Transmembrane Conductance Regulator: Roles in Chronic Obstructive Pulmonary Disease
Mark Dransfield 1, Steven Rowe 2, Claus F. Vogelmeier 3, Jadwiga Wedzicha 4, Gerard J. Criner 5, MeiLan K. Han 6, Fernando J. Martinez 7, and Peter Calverley 8
doi : 10.1164/rccm.202109-2064TR
Chronic obstructive pulmonary disease (COPD) manifests with a variety of clinical presentations, reflecting its complex pathology. Currently, care focuses on symptom amelioration and prevention of complications and thus is generally tailored to disease severity rather than targeting specific pathophysiologic mechanisms.
Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers
Sabina Illi 1,2, Martin Depner 1, Petra Ina Pfefferle 2,3, Harald Renz 2,4,5, Caroline Roduit 6,7,8, Diana Hazard Taft 9, Karen M. Kalanetra 9, David A. Mills 9, Freda M. Farquharson 10, Petra Louis 10, Elisabeth Schmausser-Hechfellner 1, Amandine Divaret-Chauveau 11,12,13, Roger Lauener 6,8, Anne M. Karvonen 14, Juha Pekkanen 14,15, Pirkka V. Kirjavainen 14,16, Marjut Roponen 17, Josef Riedler 18, Michael Kabesch 19, Bianca Schaub 2,20, Erika von Mutius 1,2,20, and the PASTURE Study Group
doi : 10.1164/rccm.202106-1458OC
Rationale: In murine models, microbial exposures induce protection from experimental allergic asthma through innate immunity.
Long-Term Air Pollution Exposure and COVID-19 Mortality: A Patient-Level Analysis from New York City
Anne Bozack 1,2,3, Stanley Pierre 4, Nicholas DeFelice 2, Elena Colicino 2, Darby Jack 5, Steven N. Chillrud 6, Andrew Rundle 7, Alfred Astua 8, James W. Quinn 7, Laura McGuinn 2, Qiang Yang 6, Keely Johnson 9, Joseph Masci 10, Laureen Lukban 11, Duncan Maru 11,12, and Alison G. Lee 1
doi : 10.1164/rccm.202104-0845OC Â
Rationale: Risk factors for coronavirus disease (COVID-19) mortality may include environmental exposures such as air pollution.
Impact of Reverse Triggering Dyssynchrony during Lung-Protective Ventilation on Diaphragm Function: An Experimental Model
L. Felipe Damiani 1,2,3, Doreen Engelberts 1, Luca Bastia 1,4, Kohei Osada 1, Bhushan H. Katira 1,5, Gail Otulakowski 1, Ewan C. Goligher 6,7,8, W. Darlene Reid 6,9, Sebastián Dubo 10, Alejandro Bruhn 3, Martin Post 1,11, Brian P. Kavanagh 1,6,11†, and Laurent J. Brochard 6,12 ... Show less
doi : 10.1164/rccm.202105-1089OC
Rationale: Reverse triggering dyssynchrony (RT) is a patient–ventilator interaction where a respiratory muscle contraction is triggered by a passive mechanical insufflation. Its impact on diaphragm structure and function is unknown.
Long-Term Safety and Efficacy of Tocilizumab in Early Systemic Sclerosis–Interstitial Lung Disease: Open-Label Extension of a Phase 3 Randomized Controlled Trial
Dinesh Khanna 1, Celia J. F. Lin 2*, Daniel E. Furst 3,4, Bridget Wagner 2, Mauro Zucchetto 5, Ganesh Raghu 6, Fernando J. Martinez 7, Jonathan Goldin 8, Jeffrey Siegel 2‡, and Christopher P. Denton 9; for the focuSSced Investigators
doi : 10.1164/rccm.202103-0714OC
Rationale: Tocilizumab, an anti–IL-6 receptor antibody, had no statistically significant effect on skin sclerosis but preserved lung function over 48 weeks in patients with early systemic sclerosis (SSc)-associated interstitial lung disease (ILD) in a phase 3 randomized controlled trial.
Thrombospondin-1 Plays a Major Pathogenic Role in Experimental and Human Bronchopulmonary Dysplasia
Brittany Ann Ruschkowski 1, Yousef Esmaeil 2, Kate Daniel 1, Chantal Gaudet 1, Behzad Yeganeh 1, David Grynspan 2, and Robert P. Jankov 1,2,3
doi : 10.1164/rccm.202104-1021OC
Rationale: Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective treatment. TSP-1 (thrombospondin-1) is an antiangiogenic protein that activates TGF-β1 (transforming growth factor-β1), a cytokine strongly linked to both experimental and human BPD.
Race/Ethnicity, Spirometry Reference Equations, and Prediction of Incident Clinical Events: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
Arielle Elmaleh-Sachs 1, Pallavi Balte 1, Elizabeth C. Oelsner 1, Norrina B. Allen 2, Aaron Baugh 3, Alain G. Bertoni 4, John L. Hankinson 5, Jim Pankow 6, Wendy S. Post 7, Joseph E. Schwartz 8, Benjamin M. Smith 1, Karol Watson 9, and R. Graham Barr 1,10
doi : 10.1164/rccm.202107-1612OC
Rationale: Normal values for FEV1 and FVC are currently calculated using cross-sectional reference equations that include terms for race/ethnicity, an approach that may reinforce disparities and is of unclear clinical benefit.
Effect of Weight Loss and Continuous Positive Airway Pressure on Obstructive Sleep Apnea and Metabolic Profile Stratified by Craniofacial Phenotype: A Randomized Clinical Trial
Susanna S. S. Ng 1, Wilson W. S. Tam 2, Richard W. W. Lee 3, Tat-On Chan 1, Karen Yiu 1, Brian T. Y. Yuen 4, Ka-Tak Wong 4, Jean Woo 1, Ronald C. W. Ma 1,5, Ken K. P. Chan 4, Fanny W. S. Ko 4, Peter A. Cistulli 6,7, and David S. Hui 1
doi : 10.1164/rccm.202106-1401OC
Rationale: Craniofacial structure is believed to modulate the effect of weight loss on obstructive sleep apnea (OSA), but whether this affects metabolic profile after weight loss compared with continuous positive airway pressure (CPAP) is unknown among obese Chinese patients with OSA.
Rapid-Onset Cystic Bronchiectasis in a Mechanically Ventilated Patient with COVID-19
Michael Gilmartin , Ahmad Basirat , Conor Barry , Hassan Rahman , Aoife Doolan , Darragh Halpenny , Brendan Hogan , Minesh Kooblall , and Stephen J. Lane *
Everolimus-Eluting Stent–induced Pneumonitis
Haruki Kobayashi
Race, Lung Function, and Long-Term Mortality in the National Health and Nutrition Examination Survey III
Meredith C. McCormack 1*, Aparna Balasubramanian 1, Elizabeth C. Matsui 2, Roger D. Peng 3, Robert A. Wise 1, and Corinne A. Keet 1
Genetic Ancestry to Improve Precision of Race/Ethnicity–based Lung Function Equations in Children
Jonathan Witonsky 1*, Jennifer R. Elhawary 1, Celeste Eng 1, José R. RodrÃÂguez-Santana 2, Luisa N. Borrell 3‡, and Esteban G. Burchard 1‡
Blood Eosinophil Counts in Chronic Obstructive Pulmonary Disease: Adding Within-Day Variability to the Equation
Inès Van Rossem *, Shane Hanon , Sylvia Verbanck , and Eef Vanderhelst
Obstructive Sleep Apnea Symptom Subtypes and Cardiovascular Risk: Conflicting Evidence to an Important Question
Brendan T. Keenan 1, Ulysses J. Magalang 2, Diego R. Mazzotti 3, Nigel McArdle 4,5,6, Thorarinn Gislason 7,8, Bhajan Singh 4,5,6, Greg Maislin 1, and Allan I. Pack 1*
Reply to Keenan et al.: Obstructive Sleep Apnea Symptom Subtypes and Cardiovascular Risk: Conflicting Evidence to an Important Question
Wojciech Trzepizur 1,2*, Margaux Blanchard 3,4, AbdelKebir Sabil 5, Chloé Gervès-Pinquié 6, and Frédéric Gagnadoux 1,2;
Making Decisions about Serious Illness: What Is Code Status?
Nehan Sher , Naomi Habib , Shiri Etzioni , and Marilyn Glassberg
doi : 10.1164/rccm.2056P11
