دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology
Lars Björndahl, Christopher L R Barratt, David Mortimer, Ashok Agarwal, Robert J Aitken, Juan G Alvarez, Natalie Aneck-Hahn, Stefan Arver, Elisabetta Baldi, LluÃs Bassas, Florence Boitrelle, Riana Bornman, Douglas T Carrell, José A Castilla, Gerardo Cerezo Parra, Jerome H Check, Patricia S Cuasnicu, Sally Perreault Darney, Christiaan de Jager, Christopher J De Jonge, Joël R Drevet, Erma Z Drobnis, Stefan S Du Plessis, Michael L Eisenberg, Sandro C Esteves, Evangelini A Evgeni, Alberto Ferlin, Nicolas Garrido, Aleksander Giwercman, Ilse G F Goovaerts, Trine B Haugen, Ralf Henkel, Lars Henningsohn, Marie-Claude Hofmann, James M Hotaling, Piotr Jedrzejczak, Pierre Jouannet, Niels Jørgensen, Jackson C Kirkman Brown, Csilla Krausz, Maciej Kurpisz, Ulrik Kvist, Dolores J Lamb, Hagai Levine, Kate L Loveland, Robert I McLachlan, Ali Mahran, Liana Maree, Sarah Martins da Silva, Michael T Mbizvo, Andreas Meinhardt, Roelof Menkveld, Sharon T Mortimer, Sergey Moskovtsev, Charles H Muller, Maria José Munuce, Monica Muratori, Craig Niederberger, Cristian O’Flaherty, Rafael Oliva, Willem Ombelet, Allan A Pacey, Michael A Palladino, Ranjith Ramasamy, Liliana Ramos, Nathalie Rives, Eduardo Rs Roldan, Susan Rothmann, Denny Sakkas, Andrea Salonia, Maria Cristina Sánchez-Pozo, Rosanna Sapiro, Stefan Schlatt, Peter N Schlegel, Hans-Christian Schuppe, Rupin Shah, Niels E Skakkebæk, Katja Teerds, Igor Toskin, Herman Tournaye, Paul J Turek, Gerhard van der Horst, Monica Vazquez-Levin, Christina Wang, Alex Wetzels, Theodosia Zeginiadou, Armand Zini
doi : 10.1093/humrep/deac189
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2497–2502
Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination.
17BIPHE2, an engineered cathelicidin antimicrobial peptide with low susceptibility to proteases, is an effective spermicide and microbicide against Neisseria gonorrhoeae
Seung Gee Lee, Wongsakorn Kiattiburut, Thitiporn Khongkha, Stephanie C Burke Schinkel, Yvonne Lunn, Aaron P Decker, Avid Mohammadi, Ana Vera-Cruz, Avika Misra, Jonathan B Angel, Deborah J Anderson, Mark Baker, Rupert Kaul, Guangshun Wang, Nongnuj Tanphaichitr
doi : 10.1093/humrep/deac188
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2503–2517
LL-37 and its truncated peptide GF-17 exert both spermicidal and microbicidal activities, although they are prone to proteolytic degradation in body fluids.
Delaying testicular sperm extraction in 47,XXY Klinefelter patients does not impair the sperm retrieval rate, and AMH levels are higher when TESE is positive
Lucie Renault, Elsa Labrune, Sandrine Giscard d’Estaing, Beatrice Cuzin, Marion Lapoirie, Mehdi Benchaib, Jacqueline Lornage, Gaëlle Soignon, André de Souza, Frédérique Dijoud, Eloïse Fraison, Laurence Pral-Chatillon, Agnès Bordes, Damien Sanlaville, Caroline Schluth–Bolard, Bruno Salle, René Ecochard, Hervé Lejeune, Ingrid Plotton
doi : 10.1093/humrep/deac203
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2518–2531
Several studies have tried to define predictive factors for TESE outcome in non-mosaic KS patients, with very heterogeneous results. Some authors have found that age was a pejorative factor and recommended performing TESE soon after puberty. To date, no predictive factors have been unanimously recognized to guide clinicians in deciding to perform TESE in azoospermic KS patients.
Assessment of first-trimester utero-placental vascular morphology by 3D power Doppler ultrasound image analysis using a skeletonization algorithm: the Rotterdam Periconception Cohort
Eline S de Vos, Anton H J Koning, Régine P M Steegers-Theunissen, Sten P Willemsen, Bas B van Rijn, Eric A P Steegers, Annemarie G M G J Mulders
doi : 10.1093/humrep/deac202
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2532–2545
Suboptimal development of the utero-placental vasculature is one of the main contributors to the periconceptional origin of placenta-related complications. The nature and attribution of aberrant vascular structure and branching patterns remain unclear, as validated markers monitoring first-trimester utero-placental vascular morphologic development are lacking.
A novel multifunctional haplotyping-based preimplantation genetic testing for different genetic conditions
Pingyuan Xie, Xiao Hu, Lingyin Kong, Yan Mao, Dehua Cheng, Kai Kang, Jing Dai, Dingding Zhao, Yi Zhang, Naru Lu, Zhenxing Wan, Renqian Du, Bo Xiong, Jun Zhang, Yueqiu Tan, Guangxiu Lu, Fei Gong, Ge Lin, Bo Liang, Juan Du, Liang Hu
doi : 10.1093/humrep/deac190
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2546–2559
Genetic disease and chromosomal rearrangement have been known to significantly impact fertility and development. Therefore, preimplantation genetic testing for aneuploidy (PGT-A), monogenic disorders (PGT-M) and structural rearrangements (PGT-SR), a part of ART, has been presented together to minimize the fetal genetic risk and increase pregnancy rate.
Circulating cell-free endometrial DNA level is unaltered during menstruation and in endometriosis
N L Yuwono, A Alonso, J Abbott, S Houshdaran, C E Henry, R Rodgers, C E Ford, K Warton
doi : 10.1093/humrep/deac198
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2560–2569
Changes in cirDNA associated with common benign conditions are a potential source of false positives in cancer diagnostic applications, but also present an opportunity for biomarker development for diseases such as endometriosis.
Clinical factors associated with low serum progesterone levels on the day of frozen blastocyst transfer in hormonal replacement therapy cycles
C Maignien, M Bourdon, L Marcellin, J Guibourdenche, A Chargui, C Patrat, G Plu-Bureau, C Chapron, P Santulli
doi : 10.1093/humrep/deac199
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2570–2577
The detrimental impact of low serum P concentrations on HRT-FET outcomes is commonly recognized. However, the factors accounting for P level disparities among patients receiving the same luteal phase support treatment remain to be elucidated, to help clinicians predicting which subgroups of patients would benefit from a tailored P supplementation.
Even high normal blood pressure affects live birth rate in women undergoing fresh embryo transfer
Huijun Chen, Xiaoli Zhang, Sufen Cai, Jian Li, Sha Tang, Carl-Friedrich Hocher, Benjamin Rösing, Liang Hu, Ge Lin, Fei Gong, Bernhard K Krämer, Berthold Hocher
doi : 10.1093/humrep/deac201
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2578–2588
Pre-pregnancy hypertension is a well-known risk factor for adverse pregnancy events such as preeclampsia, fetal growth restriction, placental abruption and adverse neonatal events.
Same-sex mothers’ experiences of equal treatment, parenting stress and disclosure to offspring: a population-based study of parenthood following identity-release sperm donation
Emilia Thorup, Gunilla Sydsjö, Claudia Lampic
doi : 10.1093/humrep/deac194
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2589–2598
Factors influencing patients’ decision-making about preimplantation genetic testing for monogenic disorders
Lin Cheng, Bettina Meiser, Edwin Kirk, Debra Kennedy, Kristine Barlow-Stewart, Rajneesh Kaur
doi : 10.1093/humrep/deac185
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2599–2610
Various factors have been shown to be associated with decision-making regarding PGT-M. However, PGT-M is experienced at an individual level, and to date, no studies have investigated the roles of the above-mentioned individual and interpersonal factors.
An online survey of UK women’s attitudes to having children, the age they want children and the effect of the COVID-19 pandemic
Joyce C Harper, Juan Sebastián Botero-Meneses
doi : 10.1093/humrep/deac209
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2611–2622
Women globally are delaying the birth of their first child, with the average age of first birth approaching 32 years in some countries. The average age women have their first child in the UK is 30.7 years and over 50% of women aged 30 years are childless.
Maternal polycystic ovarian syndrome and pubertal development in daughters and sons: a population-based cohort study
Lea Lykke Harrits Lunddorf, Linn Håkonsen Arendt, Andreas Ernst, Nis Brix, Ulla Brent Knudsen, Jørn Olsen, Cecilia Høst Ramlau-Hansen
doi : 10.1093/humrep/deac197
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2623–2634
Female adolescents with PCOS often experience earlier adrenarche compared to adolescents without PCOS, due to hyperandrogenism. Likewise, they usually have hyperandrogenism during pregnancy, which might potentially affect the development of the foetus, including its future reproductive health.
Anti-Müllerian hormone-mediated preantral follicle atresia is a key determinant of antral follicle count in mice
Y Zhou, S Richard, N J Batchelor, D E Oorschot, G M Anderson, M W Pankhurst
doi : 10.1093/humrep/deac204
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2635–2645
Most prior studies have investigated the ability of AMH to inhibit primordial follicle activation. Our previous study showed that AMH-overexpressing mice had fewer preantral follicles than expected after accounting for primordial follicle inhibition but the reason for this was not determined.
The effect of polymorphisms in FSHR gene on late follicular phase progesterone and estradiol serum levels in predicted normoresponders
A R Neves, N L Vuong, C Blockeel, S Garcia, C Alviggi, C Spits, P Q M Ma, M T Ho, H Tournaye, N P Polyzos
doi : 10.1093/humrep/deac193
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2646–2654
Previous studies have shown that late follicular phase serum progesterone and estradiol levels are significantly correlated with the magnitude of ovarian response.
Extended LH administration as a strategy to increase the pool of recruitable antral follicles in hypothalamic amenorrhea: evidence from a case series
Antonio La Marca, Maria Longo
doi : 10.1093/humrep/deac195
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2655–2661
New evidence is indicating a growing role of LH in promoting ovarian follicular growth and maturation, even at the early stages. LH seems to enhance the transition of follicles to the antral stage hence leading to an increase in the so-called functional ovarian reserve (recruitable antral follicles).
Residential proximity to a fertility clinic is independently associated with likelihood of women having ART and IUI treatment
Ester Lazzari, Bernard Baffour, Georgina M Chambers
doi : 10.1093/humrep/deac205
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2662–2671
In most countries, patients living outside of metropolitan areas are more likely to be more socio-economically disadvantaged and to have less equitable access to healthcare.
The risks of birth defects and childhood cancer with conception by assisted reproductive technology
Barbara Luke, Morton B Brown, Ethan Wantman, Maria J Schymura, Marilyn L Browne, Sarah C Fisher, Nina E Forestieri, Chandrika Rao, Hazel B Nichols, Mahsa M Yazdy, Susan T Gershman, Caitlin R Sacha, Melanie Williams, Mary K Ethen, Mark A Canfield, Kevin J Doody, Michael L Eisenberg, Valerie L Baker, Carrie Williams, Alastair G Sutcliffe, Melissa A Richard, Philip J Lupo
doi : 10.1093/humrep/deac196
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2672–2689
The rarity of the co-occurrence of birth defects, cancer and ART makes studying their association challenging.
Polycystic ovary syndrome and risk of adverse pregnancy outcomes: a registry linkage study from Massachusetts
Leslie V Farland, Judy E Stern, Chia-Ling Liu, Howard J Cabral, Charles C Coddington, III, Hafsatou Diop, Dmitry Dukhovny, Sunah Hwang, Stacey A Missmer
doi : 10.1093/humrep/deac210
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2690–2699
Prior research has suggested that women with PCOS may be at increased risk of adverse pregnancy outcomes. However, findings have been inconsistent possibly due to lack of consistent adjustment for confounding factors, small samples size and other sources of bias.
Embryo tracking system for high-throughput sequencing-based preimplantation genetic testing
Wanwisa van Dijk, Kasper Derks, Marion Drüsedau, Jeroen Meekels, Rebekka Koeck, Rick Essers, Joseph Dreesen, Edith Coonen, Christine de Die-Smulders, Servi J C Stevens, Han G Brunner, Arthur van den Wijngaard, Aimée D C Paulussen, Masoud Zamani Esteki
doi : 10.1093/humrep/deac208
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2700–2708
Although state-of-the-art sequencing-based PGT methods made a paradigm shift in PGT, they still require labor intensive library preparation steps that makes PGT cost prohibitive and poses risks of human errors.
At age 9, the methylome of assisted reproductive technology children that underwent embryo culture in different media is not significantly different on a genome-wide scale
Rebekka M Koeck, Florence Busato, Jorg Tost, Heleen Zandstra, Sylvie Remy, Sabine Langie, Marij Gielen, Ron van Golde, John C M Dumoulin, Han Brunner, Masoud Zamani Esteki, Aafke P A van Montfoort
doi : 10.1093/humrep/deac213
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2709–2721
Embryo culture in G3 or K-SICM medium leads to differences in embryonic, neonatal and childhood outcomes, including growth and weight. The methylome may mediate this association as the period of in vitro culture of ART treatments coincides with epigenetic reprogramming.
Impact of letrozole-associated controlled ovarian hyperstimulation on ART outcomes and endocrinological parameters
Oranite Goldrat, Anne Delbaere, Isabelle Demeestere
doi : 10.1093/humrep/deac206
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2722–2723
Reply: Impact of letrozole-associated controlled ovarian hyperstimulation on ART outcomes and endocrinological parameters
L C Poulsen, N S Bülow, N S Macklon, L Bungum, S O Skouby, C Yding Andersen
doi : 10.1093/humrep/deac207
Human Reproduction, Volume 37, Issue 11, November 2022, Pages 2723–2724
