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Neuroscience targets and human studies: future translational efforts in the stress system
Carolina L. Haass-Koffler & Douglas J. ShefflerÂ
doi : 10.1038/s41386-023-01539-x
Volume 48 Issue 5, April 2023
The importance of promoting scientific advocacy & outreach for trainees
Siara Kate Rouzer, Leanna Marie Kalinowski & Erin Taniyo KasedaÂ
Pramipexole modulates fronto-subthalamic pathway in sequential working memory
Marcus Heldmann, Eliana Mönch, Antonia Kesseböhmer, Norbert Brüggemann, Thomas F. Münte & Zheng YeÂ
doi : 10.1038/s41386-022-01494-z
Brain dopamine may regulate the ability to maintain and manipulate sequential information online. However, the precise role of dopamine remains unclear. This pharmacological fMRI study examined whether and how the dopamine D2/3 receptor agonist pramipexole modulates fronto-subthalamic or fronto-striatal pathways during sequential working memory.
Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice
Albert Park, Alexander D. Jacob, Hwa-Lin (Liz) Hsiang, Paul W. Frankland, John G. Howland & Sheena A. JosselynÂ
doi : 10.1038/s41386-022-01472-5
Memories allow past experiences to guide future decision making and behavior. Sparse ensembles of neurons, known as engrams, are thought to store memories in the brain. Most previous research has focused on engrams supporting threatening or fearful memories where results show that neurons involved in a particular engram (“engram neurons�) are both necessary and sufficient for memory expression. Far less is understood about engrams supporting appetitive or rewarding memories.
Medial prefrontal cortex input to basolateral amygdala controls acute stress-induced short-term anxiety-like behavior in mice
Wei-Zhu Liu, Shou-He Huang, Yu Wang, Chun-Yan Wang, Han-Qing Pan, Ke Zhao, Ping Hu, Bing-Xing Pan & Wen-Hua ZhangÂ
doi : 10.1038/s41386-022-01515-x
Anxiety is a normal and transitory emotional state that allows the organisms to cope well with the real or perceived threats, while excessive or prolonged anxiety is a key characteristic of anxiety disorders.
Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula
Jack F. Webster, Sanne Beerens & Christian WoznyÂ
doi : 10.1038/s41386-022-01493-0
Early life stress can result in depression in humans and depressive-like behaviour in rodents. In various animal models of depression, the lateral habenula (LHb) has been shown to become hyperactive immediately after early life stress.
Effects of lithium on aggression in Drosophila
Rencong Wang, Baoxu Ma, Kai Shi, Fengming Wu & Chuan ZhouÂ
doi : 10.1038/s41386-022-01475-2
Lithium is a common medication used to treat mania and bipolar disorder, but the mechanisms by which lithium stabilizes mood and modifies aggression are still not fully understood. Here we found that acute but not chronic lithium significantly suppresses aggression without affecting locomotion in Drosophila melanogaster.
Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort
Laramie Duncan, Hanyang Shen, Anton Schulmann, Tayden Li, Bhaskar Kolachana, Ajeet Mandal, Ningping Feng, Pavan Auluck & Stefano MarencoÂ
doi : 10.1038/s41386-022-01524-w
A new era of human postmortem tissue research has emerged thanks to the development of ‘omics technologies that measure genes, proteins, and spatial parameters in unprecedented detail. Also newly possible is the ability to construct polygenic scores, individual-level metrics of genetic risk (also known as polygenic risk scores/PRS), based on genome-wide association studies, GWAS.
DNA methylation GrimAge acceleration in US military veterans with PTSD
Seyma Katrinli, Anthony P. King, Elizabeth R. Duval, Alicia K. Smith, Nirmala Rajaram, Israel Liberzon & Sheila A. M. RauchÂ
doi : 10.1038/s41386-023-01537-z
Epigenetic alterations in DNA methylation might mediate gene expression effects of trauma underlying PTSD symptoms, or effects of PTSD on related health problems. PTSD is associated with all-cause morbidity and premature mortality, suggesting accelerated biological aging.
Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis
Xi Chen, Xiaopeng Song, Dost Öngür & Fei DuÂ
doi : 10.1038/s41386-023-01546-y
Multiple psychiatric disorders are characterized by a failure to suppress default-mode network (DMN) activity during tasks and by weaker anti-correlations between DMN and other brain networks at rest. However, the cellular and molecular mechanisms underlying this phenomenon are poorly understood.
Disrupted subcortical functional connectome gradient in drug-naïve first-episode schizophrenia and the normalization effects after antipsychotic treatment
Chengmin Yang, Wenjing Zhang, Jiajun Liu, Li Yao, Jeffrey R. Bishop, Rebekka Lencer, Qiyong Gong, Zhipeng Yang & Su LuiÂ
doi : 10.1038/s41386-022-01512-0
Antipsychotics are thought to improve schizophrenia symptoms through the antagonism of dopamine D2 receptors, which are abundant mainly in subcortical regions.
Acute administration of ketone beta-hydroxybutyrate downregulates 7T proton magnetic resonance spectroscopy-derived levels of anterior and posterior cingulate GABA and glutamate in healthy adults
Antoine Hone-Blanchet, Botond Antal, Liam McMahon, Andrew Lithen, Nathan A. Smith, Steven Stufflebeam, Yi-Fen Yen, Alexander Lin, Bruce G. Jenkins, Lilianne R. Mujica-Parodi & Eva-Maria RataiÂ
doi : 10.1038/s41386-022-01364-8
Glucose metabolism is impaired in brain aging and several neurological conditions. Beneficial effects of ketones have been reported in the context of protecting the aging brain, however, their neurophysiological effect is still largely uncharacterized, hurdling their development as a valid therapeutic option.
Intoxicating effects of alcohol depend on acid-sensing ion channels
Gail I. S. Harmata, Aubrey C. Chan, Madison J. Merfeld, Rebecca J. Taugher-Hebl, Anjit K. Harijan, Jason B. Hardie, Rong Fan, Jeffrey D. Long, Grace Z. Wang, Brian J. Dlouhy, Amal K. Bera, Nandakumar S. Narayanan & John A. WemmieÂ
doi : 10.1038/s41386-022-01473-4
Persons at risk for developing alcohol use disorder (AUD) differ in their sensitivity to acute alcohol intoxication. Alcohol effects are complex and thought to depend on multiple mechanisms.
Corticotropin-Releasing Factor receptor 1 (CRF1) antagonism in patients with alcohol use disorder and high anxiety levels: effect on neural response during Trier Social Stress Test video feedback
Mary R. Lee, Daniel Rio, Laura Kwako, David T. George, Markus Heilig & Reza MomenanÂ
doi : 10.1038/s41386-022-01521-z
In preclinical models of alcohol use disorder, the corticotropin-releasing factor (CRF) receptor is upregulated, particularly in the extended amygdala. This upregulation is thought to play a role in stress-induced relapse to drinking by a mechanism that is independent of the hypothalamic-pituitary-adrenal axis.
Chronic MAP4343 reverses escalated alcohol drinking in a mouse model of alcohol use disorder
Giovana C. Macedo, Max Kreifeldt, Scott P. Goulding, Agbonlahor Okhuarobo, Harpreet Sidhu & Candice ContetÂ
doi : 10.1038/s41386-023-01529-z
Alcohol use disorders can be driven by negative reinforcement. Alterations of the microtubule cytoskeleton have been associated with mood regulation in the context of depression. Notably, MAP4343, a pregnenolone derivative known to promote tubulin assembly, has antidepressant properties. In the present study, we tested the hypothesis that MAP4343 may reduce excessive alcohol drinking in a mouse model of alcohol dependence by normalizing affect during withdrawal.
Essential role of P-glycoprotein in the mechanism of action of oliceridine
Emilya Ventriglia, Arianna Rizzo, Juan L. Gomez, Jacob Friedman, Sherry Lam, Oscar SolÃÂs, Rana Rais, Jordi Bonaventura & Michael MichaelidesÂ
doi : 10.1038/s41386-022-01507-x
Mu opioid receptor (MOR) agonists comprise the most effective analgesics, but their therapeutic utility is limited by adverse effects. One approach for limiting such effects has been to develop “biased� MOR agonists that show preference for activating G protein over β-Arrestin signaling.
IN MEMORIAM Ghanshyam Narayan Pandey 1937–2022
Anand KumarÂÂ
William T. McKinney, Jr., MD 1937–2022
Douglas A. Kramer & Stephen J. SuomiÂ
Correction To: TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT1A receptor agonist SEP- 363856
Marcus Saarinen, Ioannis Mantas, Ivana Flais, Richard Ã…gren, Kristoffer Sahlholm, Mark J. Millan & Per SvenningssonÂ
