دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Experimental Neurotherapeutics: Surfing the Tidal Wave of New Opportunities
Lauren B. Reoma MD, Ania Busza MD, PhD, M. Maral Mouradian MD, Petra Kaufmann MD, Erika F. Augustine MD, MS, Samuel Frank MD, Thomas P. Sutula MD, PhD, Andrew J. Cole MD, Heather D. Fitter MD, William Meurer MD, MS, Avindra Nath MD, Robert C. Griggs MD
doi : 10.1002/ana.26582
The subspecialty of experimental neurotherapeutics trains neurologists in discovering and developing new treatments for neurologic diseases. Based on development of exciting new treatments for genetic and inflammatory diseases, we predict that there will be many other breakthroughs.
Cell-Specific Dysregulation of Iron and Oxygen Homeostasis as a Novel Pathophysiology in PSP
Seojin Lee BMSc, Ivan Martinez-Valbuena PhD, Carlos E. de Andrea MD, PhD, Maria Villalba-Esparza PhD, Suganthini Ilaalagan BEng/Bsc, Blas Couto MD, Naomi P. Visanji PhD, Anthony E. Lang MD, FRCPC, Gabor G. Kovacs MD, PhD, FRCPC
doi : 10.1002/ana.26540
Progressive supranuclear palsy (PSP) is a 4R-tauopathy showing heterogeneous tau cytopathology commencing in the globus pallidus (GP) and the substantia nigra (SN), regions also associated with age-related iron accumulation
A Combined Panel of Salivary Biomarkers in de novo Parkinson's Disease
Maria Ilenia De Bartolo MD, Giorgio Vivacqua MD, PhD, Daniele Belvisi MD, PhD, Romina Mancinelli PhD, Andrea Fabbrini MD, Nicoletta Manzo MD, PhD, Matteo Costanzo MD, Giorgio Leodori MD, PhD, Antonella Conte MD, PhD, Giovanni Fabbrini MD, Sergio Morini MD, Alfredo Berardelli MD
doi : 10.1002/ana.26550
To investigate molecular biomarkers of a-synuclein and tau aggregation, autophagy, and inflammation in the saliva of de novo Parkinson's disease (PD) patients in comparison to healthy subjects (HS), and to correlate molecular data with clinical features of PD patients, in order to establish whether abnormalities of these parameters are associated with specific clusters of de novo PD patients, and their potential diagnostic power in differentiating PD patients from HS.
DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia
Dongren Yao PhD, Lena C. O'Flynn BA, Kristina Simonyan MD, PhD, DrMed
doi : 10.1002/ana.26558
Isolated dystonia is characterized by abnormal, often painful, postures and repetitive movements due to sustained or intermittent involuntary muscle contractions. Botulinum toxin (BoTX) injections into the affected muscles are the first line of therapy. However, there are no objective predictive markers or standardized tests of BoTX efficacy that can be utilized for appropriate candidate selection prior to treatment initiation.
Extra Movements in Healthy People: Challenging the Definition and Diagnostic Practice of Tic Disorders
Stefanie Bartha BSc, Annet Bluschke PhD, Tina Rawish MSc, Kim E. R. Naumann, Paul Wendiggensen MSc, Tobias Bäumer MD, Veit Roessner MD, Alexander Münchau MD, Christian Beste PhD
doi : 10.1002/ana.26586
The occurrence of motor/vocal tics, that is, “extra movements� and/or “extra vocalizations,� is the leading diagnostic criterion for tic disorders. We show that extra movements are common also in healthy controls, so that a surplus of movements per se is not indicative of the presence of a tic disorder.
Atrial Fibrillation Risk Assessment after Embolic Stroke of Undetermined Source
Aenne S. von Falkenhausen MD, Katharina Feil MD, Moritz F. Sinner MD, MPH, Sonja Schönecker MD, Johanna Müller MD, Johannes Wischmann MD, Elodie Eiffener MSc, Sebastian Clauss MD, Sven Poli MD, Khouloud Poli MD, Christine S. Zuern MD, Ulf Ziemann MD, Jörg Berrouschot MD, Alkisti Kitsiou, Wolf-Rüdiger Schäbitz MD, Marianne Dieterich MD, Steffen Massberg MD, Stefan Kääb MD, PhD, Lars Kellert MD
doi : 10.1002/ana.26545
Approximately 20% of strokes are embolic strokes of undetermined source (ESUS). Undetected atrial fibrillation (AF) remains an important cause. Yet, oral anticoagulation in unselected ESUS patients failed in secondary stroke prevention.
Tenecteplase Improves Reperfusion across Time in Large Vessel Stroke
Vignan Yogendrakumar MD, James Beharry MBChB, Leonid Churilov PhD, Khairunnisa Alidin CNC, Melissa Ugalde CNC, Lauren Pesavento CNC, Louise Weir NP, Peter J. Mitchell MMed, Timothy J. Kleinig PhD, Nawaf Yassi PhD, Vincent Thijs PhD, Teddy Y. Wu PhD, Darshan G. Shah MBBS, Helen M. Dewey PhD, Tissa Wijeratne PhD, Bernard Yan DMedSc, Patricia M. Desmond MD, Gagan Sharma MCA, Mark W. Parsons PhD, Geoffrey A. Donnan MD, Stephen M. Davis MD, Bruce C. V. Campbell PhD, for the Royal Melbourne Stroke Registry and EXTEND-IA TNK Collaborators
doi : 10.1002/ana.26547
Tenecteplase improves reperfusion compared to alteplase in patients with large vessel occlusions. To determine whether this improvement varies across the spectrum of thrombolytic agent to reperfusion assessment times, we performed a comparative analysis of tenecteplase and alteplase reperfusion rates.
Plasma Metabolites Link Dietary Patterns to Stroke Risk
Varun M. Bhave BA, Zsuzsanna Ament PhD, Amit Patki MS, Yan Gao MPH, Naruchorn Kijpaisalratana MD, PhD, Boyi Guo MS, Ninad S. Chaudhary PhD, Ana-Lucia Garcia Guarniz MD, Robert Gerszten MD, Adolfo Correa MD, PhD, Mary Cushman MD, MS, Suzanne Judd PhD, M. Ryan Irvin PhD, W. Taylor Kimberly MD, PhD
doi : 10.1002/ana.26552
While dietary intake is linked to stroke risk, surrogate markers that could inform personalized dietary interventions are lacking. We identified metabolites associated with diet patterns and incident stroke in a nested cohort from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.
A Managed Care System with Telemedicine Support for Neurological Emergencies
Hebun Erdur MD, Joachim E. Weber MD, Anselm Angermaier MD, Stephan Kinze MD, Ali Sotoodeh MD, Claudia Gorski Dipl FH, Kerstin Bollweg PhD, Stefanie Ernst MSc, Farid I. Kandil PhD, Janina Behrens MD, Ramanan Ganeshan MD, Anne Keysers MD, Malgorzata Kotlarz-Böttcher MD, Daniel Peters MD, Ludwig Schlemm MD, Kirsten Stangenberg-Gliss Dipl FH, Carl Witt MD, Beata Hennig Dipl FH, Katrin C. Reber PhD, Udo Schneider PhD, Christiana Franke MD, Ingo Schmehl MD, Hans-Beatus Straub MD, Agnes Flöel MD, Sarah Theen MSc, Matthias Endres MD, Tobias Kurth MD, Heinrich J. Audebert MD
doi : 10.1002/ana.26556
Telemedicine is frequently used to provide remote neurological expertise for acute stroke workup and was associated with better functional outcomes when combined with a stroke unit system-of-care.
A Subpopulation of Spikes Predicts Successful Epilepsy Surgery Outcome
John Thomas PhD, Philippe Kahane MD, PhD, Chifaou Abdallah MD, Tamir Avigdor MSc, Willemiek J. E. M. Zweiphenning MD, Stephan Chabardes MD, PhD, Kassem Jaber B. Eng., Véronique Latreille PhD, Lorella Minotti MD, Jeff Hall MD, François Dubeau MD, Jean Gotman PhD, Birgit Frauscher MD, PD
doi : 10.1002/ana.26548
Epileptic spikes are the traditional interictal electroencephalographic (EEG) biomarker for epilepsy. Given their low specificity for identifying the epileptogenic zone (EZ), they are given only moderate attention in presurgical evaluation.
Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy
Annika Reimers MS, Christoph Helmstaedter PhD, Christian E. Elger MD, Julika Pitsch PhD, Motaz Hamed MD, Albert J. Becker MD, Juri-Alexander Witt PhD
doi : 10.1002/ana.26557
Some patients unexpectedly display an unfavorable cognitive course after epilepsy surgery subsequent to any direct cognitive sequelae of the surgical treatment. Therefore, we conducted in-depth neuropathological examinations of resective specimens from corresponding patients to provide insights as to the underlying disease processes.
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations
Jacqueline M. Cohen PhD, Silje Alvestad MD, PhD, Carolyn E. Cesta PhD, Marte-Helene Bjørk MD, PhD, Maarit K. Leinonen MD, PhD, Mette Nørgaard MD, PhD, Kristjana Einarsdóttir PhD, Anders Engeland PhD, Mika Gissler PhD, Øystein Karlstad PhD, Kari Klungsøyr MD, PhD, Ingvild Odsbu PhD, Johan Reutfors MD, PhD, Randi M. Selmer PhD, Torbjörn Tomson MD, PhD, Sinna Pilgaard Ulrichsen MSc, Helga Zoega PhD, Kari Furu PhD
doi : 10.1002/ana.26561
This study was undertaken to examine the comparative safety of antiseizure medication (ASM) monotherapy in pregnancy with respect to risk of major congenital malformations (MCMs), overall and by MCM subtype.
Disease Progression in Charcot–Marie–Tooth Disease Related to MPZ Mutations: A Longitudinal Study
Vera Fridman MD, Stefan Sillau PhD, Jacob Bockhorst BA, Kaitlin Smith MS, CGC, Isabella Moroni MD, Emanuela Pagliano MD, Chiara Pisciotta MD, PhD, Guiseppe Piscosquito MD, Matilde Laurá MD, PhD, Francesco Muntoni MD, FRCPCH, Chelsea Bacon BS, Shawna Feely MS, CGC, Tiffany Grider MS, CGC, Laurie Gutmann MD, Rosemary Shy MD, Janel Wilcox MS, CGC, David N. Herrmann MD, Jun Li MD, PhD, Sindhu Ramchandren MD, MS, Charlotte J. Sumner MD, Thomas E. Lloyd MD, PhD, John Day MD, PhD, Carly E. Siskind MS, CGC, Sabrina W. Yum MD, Reza Sadjadi MD, Richard S. Finkel MD, Steven S. Scherer MD, PhD, Davide Pareyson MD, Mary M. Reilly MD, FCRP, Michael E. Shy MD, the Inherited Neuropathies Consortium–Rare Diseases Clinical Research Network
doi : 10.1002/ana.26518
The paucity of longitudinal natural history studies in MPZ neuropathy remains a barrier to clinical trials. We have completed a longitudinal natural history study in patients with MPZ neuropathies across 13 sites of the Inherited Neuropathies Consortium.
Tubers Affecting the Fusiform Face Area Are Associated with Autism Diagnosis
Alexander L. Cohen MD, PhD, Mallory R. Kroeck MA, Juliana Wall BA, Peter McManus BA, Arina Ovchinnikova BS, Mustafa Sahin MD, PhD, Darcy A. Krueger MD, PhD, E. Martina Bebin MD, MPA, Hope Northrup MD, Joyce Y. Wu MD, Simon K. Warfield PhD, Jurriaan M. Peters MD, PhD, Michael D. Fox MD, PhD
doi : 10.1002/ana.26551
Tuberous sclerosis complex (TSC) is associated with focal brain “tubers� and a high incidence of autism spectrum disorder (ASD). The location of brain tubers associated with autism may provide insight into the neuroanatomical substrate of ASD symptoms.
Breast Milk Exposure is Associated With Cortical Maturation in Preterm Infants
Gemma Sullivan MRCPCH, PhD, Kadi Vaher BA, MRes, Manuel Blesa PhD, Paola Galdi PhD, David Q. Stoye MRCPCH, PhD, Alan J. Quigley MBChB, FRCR, Michael J. Thrippleton PhD, John Norrie MSc, Mark E. Bastin DPhil, James P. Boardman FRCPCH, PhD
doi : 10.1002/ana.26559
Breast milk exposure is associated with improved neurocognitive outcomes following preterm birth but the neural substrates linking breast milk with outcome are uncertain. We tested the hypothesis that high versus low breast milk exposure in preterm infants results in cortical morphology that more closely resembles that of term-born infants.
Dimethyl Fumarate Delays Multiple Sclerosis in Radiologically Isolated Syndrome
Darin T. Okuda MD, Orhun Kantarci MD, Christine Lebrun-Frénay MD, PhD, Maria Pia Sormani PhD, Christina J. Azevedo MD, MPH, Francesca Bovis PhD, Le H. Hua MD, Lilyana Amezcua MD, MS, Ellen M. Mowry MD, MCR, Christophe Hotermans MD, PhD, Jason Mendoza PhD, John S. Walsh MD, Christian von Hehn MD, PhD, Wendy S. Vargas MD, Stacy Donlon MD, Robert T. Naismith MD, Annette Okai MD, Gabriel Pardo MD, Pavle Repovic MD, PhD, Olaf Stüve MD, PhD, Aksel Siva MD, Daniel Pelletier MD
doi : 10.1002/ana.26555
The radiologically isolated syndrome (RIS) represents the earliest detectable pre-clinical phase of multiple sclerosis (MS). This study evaluated the impact of therapeutic intervention in preventing first symptom manifestation at this stage in the disease spectrum.
Pathogen and Antibody Identification in Children with Encephalitis in Myanmar
Maria M. Galardi MD, Gavin M. Sowa MD, MS, Cameron D. Crockett MD, Robert Rudock MD, Alyssa E. Smith MD, Ei E. Shwe MBBS, Thidar San MBBS, Kyaw Linn MBBS, Aye Mya M. Aye MBBS, Prashanth S. Ramachandran MBBS, Maham Zia BA, Anne E. Wapniarski BA, Isobel A. Hawes BA, Chaw S. Hlaing MBBS, Ei H. Kyu MBBS, Cho Thair MBBS, Yi Y. Mar MBBS, Nway Nway MBBS, Gregory A. Storch MD, Kristine M. Wylie PhD, Todd N. Wylie BS, Josep Dalmau MD PhD, Michael R. Wilson MD, MAS, Soe S. Mar MD
doi : 10.1002/ana.26560
Prospective studies of encephalitis are rare in regions where encephalitis is prevalent, such as low middle-income Southeast Asian countries. We compared the diagnostic yield of local and advanced tests in cases of pediatric encephalitis in Myanmar.
Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife
Willa D. Brenowitz PhD, MPH, Myriam Fornage PhD, Lenore J. Launer PhD, Mohamad Habes PhD, Christos Davatzikos PhD, Kristine Yaffe MD
doi : 10.1002/ana.26569
We examined associations of an Alzheimer's disease (AD) Genetic Risk Score (AD-GRS) and midlife cognitive and neuroimaging outcomes in 1,252 middle-aged participants (311 with brain MRI).
Increased Cerebellum 18F-DPA-714 Uptake in Anti-Glutamate Kainate Receptor Subunit 2 Autoimmune Encephalitis
Yizongheng Zhang BM, Qinming Zhou MD, PhD, Lisheng Peng PhD, Sheng Chen MD, PhD
doi : 10.1002/ana.26563
Intracranial Aneurysmosis with Multilobular Aneurysms and Brain Microaneurysms
Andrew Jin MD, Crystal Fong MD, Jian-Qiang Lu MD, PhD
doi : 10.1002/ana.26571
