دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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http://medilib.ir
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In Memoriam: Arthur Knight Asbury, MD (1928–2022)
Mark J. Brown MD, Frances E. Jensen MD, FANA, Howard Hurtig MD
doi : 10.1002/ana.26553
ANAÂ Podcasts & Webinars: Genetics of Epilepsy
Rohit R. Das MD, Adeline L. Goss MD, Ingrid E. Scheffer AO, MBBS, PhD
doi : 10.1002/ana.26546
A Causal Classification System for Intracerebral Hemorrhage Subtypes
Nicolas Raposo MD, PhD, Maria Clara Zanon Zotin MD, David J. Seiffge MD, Qi Li MD, PhD, Martina B. Goeldlin MD, Andreas Charidimou MD, PhD, Ashkan Shoamanesh MD, Hans Rolf Jäger MD, FRCP, Charlotte Cordonnier MD, PhD, Catharina JM Klijn MD, PhD, Eric E. Smith MD, MPH, Steven M. Greenberg MD, PhD, David J. Werring MD, PhD, Anand Viswanathan MD, PhD
doi : 10.1002/ana.26519
Determining the underlying causes of intracerebral hemorrhage (ICH) is of major importance, because risk factors, prognosis, and management differ by ICH subtype. We developed a new causal CLASsification system for ICH Subtypes, termed CLAS-ICH, based on recent advances in neuroimaging.
CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI
Hilde van den Brink MSc, Anna Kopczak MD, Tine Arts PhD, Laurien Onkenhout MD, Jeroen C.W. Siero PhD, Jaco J.M. Zwanenburg PhD, Sandra Hein BSc, Mathias Hübner MSc, Benno Gesierich PhD, Marco Duering MD, Michael S. Stringer PhD, Jeroen Hendrikse MD, PhD, Joanna M. Wardlaw MD, Anne Joutel MD, PhD, Martin Dichgans MD, Geert Jan Biessels MD, PhD, on behalf of the SVDs@target group
doi : 10.1002/ana.26527
Cerebral small vessel diseases (cSVDs) are a major cause of stroke and dementia. We used cutting-edge 7T-MRI techniques in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), to establish which aspects of cerebral small vessel function are affected by this monogenic form of cSVD.
Predicting Functional Outcome Using 24-Hour Post-Treatment Characteristics: Application of Machine Learning Algorithms in the STRATIS Registry
Alicia C. Castonguay PhD, Zeinab Zoghi MS, Osama O. Zaidat MD, MS, Richard E. Burgess MD, PhD, Syed F. Zaidi MD, Nils Mueller-Kronast MD, David S. Liebeskind MD, Mouhammad A. Jumaa MD
doi : 10.1002/ana.26528
Machine learning (ML) algorithms have emerged as powerful predictive tools in the field stroke. Here, we examine the predictive accuracy of ML models for predicting functional outcomes using 24-hour post-treatment characteristics in the Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke (STRATIS) Registry.
Effect of Mobile Stroke Unit Dispatch in all Patients with Acute Stroke or TIA
Jessica L. Rohmann MScPH, Marco Piccininni PhD, Martin Ebinger MD, Matthias Wendt MD, Joachim E. Weber MD, Eugen Schwabauer MD, Frederik Geisler MD, Erik Freitag MD, Peter Harmel MD, Irina Lorenz-Meyer MSc, Ira Rohrpasser-Napierkowski Dr rer. nat., Christian H. Nolte MD, Darius G. Nabavi MD, Ingo Schmehl MD, Axel Ekkernkamp MD, Matthias Endres MD, Heinrich J. Audebert MD
doi : 10.1002/ana.26541
To determine the effect of additional mobile stroke unit (MSU) dispatch on functional outcomes among the full spectrum of stroke patients, regardless of subtype or potential contraindications to reperfusion therapies.
Infratentorial Superficial Siderosis and Spontaneous Intracranial Hypotension
Wouter I. Schievink MD, M. Marcel Maya MD, Jennifer Harris MD, Javier Galvan MD, Rachelle B. Taché NP-C, MSN, Miriam Nuño PhD
doi : 10.1002/ana.26521
Spontaneous spinal cerebrospinal fluid (CSF) leaks cause intracranial hypotension (SIH) and also may cause infratentorial superficial siderosis (iSS) but the rate of development among different CSF leak types and outcome of treatment are not known. We determined the time interval from SIH onset to iSS and the outcome of treatment.
Trans-Synaptic Degeneration Following Acute Optic Neuritis in Multiple Sclerosis
Olwen C. Murphy MBBCh, Elias S. Sotirchos MD, Grigorios Kalaitzidis MD, Elena Vasileiou MD, Henrik Ehrhardt MBBCh, Jeffrey Lambe MBBCh, Ohemaa Kwakyi BS, James Nguyen MD, Alexandra Zambriczki Lee BS, Julia Button MD, Blake E. Dewey PhD, Scott D. Newsome DO, Ellen M. Mowry MD, Kathryn C. Fitzgerald ScD, Jerry L. Prince PhD, Peter A. Calabresi MD, Shiv Saidha MBBCh
doi : 10.1002/ana.26529
To explore longitudinal changes in brain volumetric measures and retinal layer thicknesses following acute optic neuritis (AON) in people with multiple sclerosis (PwMS), to investigate the process of trans-synaptic degeneration, and determine its clinical relevance.
Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir
Alexander Grundmann BMBCh, Chieh-Hsi Wu PhD, Marc Hardwick BMBCh, J. Kenneth Baillie FRCA, PhD, Peter J M Openshaw FRCP, PhD, Malcolm G. Semple FRCPCH, PhD, Dankmar Böhning PhD, Sarah Pett FRACP, PhD, Benedict D. Michael FRCP, PhD, Rhys H. Thomas FRCP, PhD, Ian Galea FRCP, PhD, for the ISARIC4C investigators
doi : 10.1002/ana.26536
The objective of this study was to assess the impact of treatment with dexamethasone, remdesivir or both on neurological complications in acute coronavirus diease 2019 (COVID-19).
Ocrelizumab Concentration Is a Good Predictor of SARS-CoV-2 Vaccination Response in Patients with Multiple Sclerosis
Zoé L. E. van Kempen, Laura Hogenboom, Alyssa A. Toorop, Maurice Steenhuis, Eileen W. Stalman, Laura Y. L. Kummer, Koos P. J. van Dam, Karien Bloem, Anja ten Brinke, S. Marieke van Ham, Taco W. Kuijpers, Gerrit J. Wolbink, Floris C. Loeff, Luuk Wieske, Filip Eftimov, Theo Rispens, Eva M. M. Strijbis, Joep Killestein, on behalf of the T2B! immunity against SARS-CoV-2 study group
doi : 10.1002/ana.26534
Ocrelizumab, an anti-CD20 monoclonal antibody, counteracts induction of humoral immune responses after severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccinations in patients with multiple sclerosis (MS).
Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System
Coral M. Stredny MD, Melissa M. Blessing DO, Vivian Yi BS, Morgan E. Ryan MS, Bo Zhang PhD, Isaac H. Solomon MD, PhD, Sanjay P. Prabhu MBBS, Sanda Alexandrescu MD, Mark P. Gorman MD
doi : 10.1002/ana.26531
Small vessel primary angiitis of the central nervous system is a rare and often severe disease characterized by central nervous system-restricted inflammatory vasculitis on histopathology.
Exploring Gene Expression Profiles in Primary Central Nervous System Vasculitis
Carlo Salvarani MD, Jonas Paludo MD, Gene G. Hunder MD, Stephen M. Ansell MD, Caterina Giannini MD, Joseph E. Parisi MD, John Huston III MD, Matthew J. Koster MD, Kenneth J. Warrington MD, Stefania Croci BS, PhD, Robert D. Brown Jr MD, MPH
doi : 10.1002/ana.26537
This study was undertaken to explore the gene expression profile of primary central nervous system vasculitis (PCNSV).
Functional Neuroimaging as an Assessment Tool in Critically Ill Patients
Loretta Norton PhD, Karnig Kazazian BSc, Teneille Gofton MD, Derek B. Debicki MD, PhD, Davinia Fernandez-Espejo PhD, Jonathan E. Peelle PhD, Eyad Al Thenayan MD, G. Bryan Young MD, Adrian M. Owen PhD
doi : 10.1002/ana.26530
Little is known about residual cognitive function in the earliest stages of serious brain injury. Functional neuroimaging has yielded valuable diagnostic and prognostic information in chronic disorders of consciousness, such as the vegetative state (also termed unresponsive wakefulness syndrome).
Synaptic Loss in Frontotemporal Dementia Revealed by [11C]UCB-J Positron Emission Tomography
Maura Malpetti PhD, P. Simon Jones PhD, Thomas E. Cope MD, PhD, Negin Holland MD, PhD, Michelle Naessens MSc, Matthew A. Rouse MSc, Timothy Rittman MD, PhD, George Savulich PhD, David J. Whiteside MD, Duncan Street MD, PhD, Tim D. Fryer PhD, Young T. Hong PhD, Selena Milicevic Sephton PhD, Franklin I. Aigbirhio DPhil, John T. O′Brien FRCPsych, DM, James B. Rowe FRCP, PhD
doi : 10.1002/ana.26543
Synaptic loss is an early feature of neurodegenerative disease models, and is severe in post mortem clinical studies, including frontotemporal dementia. Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle glycoprotein 2A enables quantification of synaptic density in vivo.
CYFIP2 p.Arg87Cys Causes Neurological Defects and Degradation of CYFIP2
Muwon Kang BSc, Yinhua Zhang PhD, Hyae Rim Kang BSc, Seoyeong Kim BSc, Ruiying Ma BSc, Yunho Yi, Seungjoon Lee PhD, Yoonhee Kim MSc, Huiling Li BSc, Chunmei Jin PhD, Dongmin Lee MD, PhD, Eunjoon Kim PhD, Kihoon Han PhD
doi : 10.1002/ana.26535
Here, we report the generation and comprehensive characterization of a knockin mouse model for the hotspot p.Arg87Cys variant of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene, which was recently identified in individuals diagnosed with West syndrome, a developmental and epileptic encephalopathy.
Magnetic Resonance Images Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction in Alzheimer Disease
Jung-Lung Hsu MD, PhD, Yi-Chia Wei MD, PhD, Cheng Hong Toh MD, PhD, Ing-Tsung Hsiao PhD, Kun-Ju Lin MD, PhD, Tzu-Chen Yen MD, PhD, Ming-Feng Liao MD, PhD, Long-Sun Ro MD, PhD
doi : 10.1002/ana.26516
The glymphatic system cleans amyloid and tau proteins from the brain in animal studies of Alzheimer disease (AD). However, there is no direct evidence showing this in humans.
Responses of Chemosensory Perception to Stimulation of the Human Brain
Yanyan Li PhD, Zheng Tan PhD, Jing Wang MBBS, Yufei Cai BS, Mengyang Wang MD, Wen Zhou PhD, Liang Wang PhD
doi : 10.1002/ana.26532
Significant advances have been made in our understanding of the neural substrates of human chemosensory processing, involving the piriform cortex, insula, and orbitofrontal cortex.
Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always
W. R. Wayne Martin MD, John R. Younce MD, Meghan C. Campbell PhD, Brad A. Racette MD, Scott A. Norris MD, Mwiza Ushe MD, Susan Criswell MD, Albert A. Davis MD, PhD, Isabel Alfradique-Dunham MD, Baijayanta Maiti MD, PhD, Nigel J. Cairns PhD, Richard J. Perrin MD, PhD, Paul T. Kotzbauer MD, PhD, Joel S. Perlmutter MD
doi : 10.1002/ana.26542
The objective of this study was to evaluate the relationship between Parkinson's disease (PD) with dementia and cortical proteinopathies in a large population of pathologically confirmed patients with PD.
Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease
Tommaso Schirinzi MD, PhD, Daniela Maftei PhD, Francesco M. Passali MD, PhD, Piergiorgio Grillo MD, Henri Zenuni MD, Davide Mascioli MD, Riccardo Maurizi MD, Laura Loccisano MD, Martina Vincenzi PhD, Anna Maria Rinaldi, Massimo Ralli MD, PhD, Stefano Di Girolamo MD, Alessandro Stefani MD, PhD, Roberta Lattanzi PhD, Cinzia Severini PhD, Nicola B. Mercuri MD, PhD
doi : 10.1002/ana.26526
The objective of this study was to outline the dynamics of prokineticin-2 pathway in relation to clinical-pathological features of Parkinson's disease by examining olfactory neurons of patients.
Nocturnal Pulse Event Frequency Is Reduced in Multiple System Atrophy
Stuart J. McCarter MD, Elizabeth A. Coon MD, Eduardo E. Benarroch MD, Michael H. Silber MB, ChB, Erik K. St. Louis MD, MS
doi : 10.1002/ana.26533
Risk of sudden death in multiple system atrophy (MSA) is greatest during sleep with unknown mechanisms. We compared nocturnal pulse event frequency in 46 MSA patients and age-/sex-matched controls undergoing overnight pulse oximetry.
