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Synaptic plasticity as a therapeutic target to modulate circuits in psychiatric disorders
Marina E. Wolf & Anissa Abi-DarghamÂÂ
doi : 10.1038/s41386-022-01458-3
Volume 48 Issue 1, January 2023
Net gain and loss: influence of natural rewards and drugs of abuse on perineuronal nets
Travis E. Brown & Barbara A. SorgÂÂ
doi : 10.1038/s41386-022-01337-x
Overindulgence, excessive consumption, and a pattern of compulsive use of natural rewards, such as certain foods or drugs of abuse, may result in the development of obesity or substance use disorder, respectively.
Astrocyte regulation of synaptic signaling in psychiatric disorders
Anna Kruyer, Peter W. Kalivas & Michael D. ScofieldÂÂ
doi : 10.1038/s41386-022-01338-w
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical role of astroglia in shaping neuronal synaptic activity and along with the pre- and postsynapse is now considered an equal partner in tripartite synaptic transmission and plasticity.
Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment
Andrew Scheyer, Farhana Yasmin, Saptarnab Naskar & Sachin PatelÂÂ
doi : 10.1038/s41386-022-01438-7
Endocannabinoids (eCBs) are lipid neuromodulators that suppress neurotransmitter release, reduce postsynaptic excitability, activate astrocyte signaling, and control cellular respiration.
Rapid homeostatic plasticity and neuropsychiatric therapeutics
Ege T. Kavalali & Lisa M. MonteggiaÂÂ
doi : 10.1038/s41386-022-01411-4
Neuronal and synaptic plasticity are widely used terms in the field of psychiatry. However, cellular neurophysiologists have identified two broad classes of plasticity.
Sleep-mediated regulation of reward circuits: implications in substance use disorders
Rong Guo, Dylan Thomas Vaughan, Ana Lourdes Almeida Rojo & Yanhua H. HuangÂÂ
doi : 10.1038/s41386-022-01356-8
Our modern society suffers from both pervasive sleep loss and substance abuse�what may be the indications for sleep on substance use disorders (SUDs), and could sleep contribute to the individual variations in SUDs? Decades of research in sleep as well as in motivated behaviors have laid the foundation for us to begin to answer these questions.
Neural circuits regulating prosocial behaviors
Jessica J. Walsh, Daniel J. Christoffel & Robert C. MalenkaÂÂ
doi : 10.1038/s41386-022-01348-8
Positive, prosocial interactions are essential for survival, development, and well-being. These intricate and complex behaviors are mediated by an amalgamation of neural circuit mechanisms working in concert.
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Scott M. ThompsonÂÂ
doi : 10.1038/s41386-022-01422-1
What changes in brain function cause the debilitating symptoms of depression? Can we use the answers to this question to invent more effective, faster acting antidepressant drug therapies? This review provides an overview and update of the converging human and preclinical evidence supporting the hypothesis that changes in the function of excitatory synapses impair the function of the circuits they are embedded in to give rise to the pathological changes in mood, hedonic state, and thought processes that characterize depression.
Towards an understanding of psychedelic-induced neuroplasticity
Abigail E. Calder & Gregor HaslerÂÂ
doi : 10.1038/s41386-022-01389-z
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and addiction.
Synaptic plasticity and mental health: methods, challenges and opportunities
Lawrence G. Appelbaum, Mohammad Ali Shenasa, Louise Stolz & Zafiris DaskalakisÂÂ
doi : 10.1038/s41386-022-01370-w
Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that allows neurons to communicate and change their connections as a function of past experiences.
Adaptive control of synaptic plasticity integrates micro- and macroscopic network function
Daniel N. Scott & Michael J. FrankÂÂ
doi : 10.1038/s41386-022-01374-6
Synaptic plasticity configures interactions between neurons and is therefore likely to be a primary driver of behavioral learning and development.
Sustained effects of single doses of classical psychedelics in humans
Gitte M. KnudsenÂÂ
doi : 10.1038/s41386-022-01361-x
The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca).
Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
Oliver D. Howes, Connor Cummings, George E. Chapman & Ekaterina ShatalinaÂÂ
doi : 10.1038/s41386-022-01426-x
Over the last five decades, a large body of evidence has accrued for structural and metabolic brain alterations in schizophrenia.
Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity
Sophia Vinogradov, Matthew V. Chafee, Erik Lee & Hirofumi MorishitaÂÂ
doi : 10.1038/s41386-022-01451-w
Emerging research on neuroplasticity processes in psychosis spectrum illnesses�from the synaptic to the macrocircuit levels�fill key gaps in our models of pathophysiology and open up important treatment considerations.
Imaging synaptic density in depression
Sophie E. Holmes, Chadi Abdallah & Irina EsterlisÂÂ
doi : 10.1038/s41386-022-01368-4
Major depressive disorder is a prevalent and heterogeneous disorder with treatment resistance in at least 50% of individuals.
Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation
Ali Jannati, Lindsay M. Oberman, Alexander Rotenberg & Alvaro Pascual-LeoneÂÂ
doi : 10.1038/s41386-022-01453-8
Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain stimulation based on electromagnetic induction where a fluctuating magnetic field induces a small intracranial electric current in the brain.
Using metabolic imaging to investigate neuromodulatory mechanisms of rTMS
Joseph A. Deluisi & Desmond J. OathesÂÂ
Schrooms against booze: Potential of mycotherapy for the treatment of AUD
Marcus W. Meinhardt & Wolfgang H. SommerÂÂ
Neurotrophic effects of potentiating gaba-mediated dendritic inhibition
Thomas D. Prevot & Etienne SibilleÂÂ
Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects
Katherine M. Nautiyal & David B. YadenÂÂ
Probing long-term potentiation-like visual cortical plasticity in humans using repeated visual stimulation: effects on visual evoked potentials
Holly K. Hamilton & Daniel H. MathalonÂÂ
Neuroimaging of plasticity mechanisms in the human brain: from critical periods to psychiatric conditions
Valerie J. Sydnor & Theodore D. SatterthwaiteÂÂ
N6-methyladenosine (m6A) epitranscriptomics in synaptic plasticity and behaviors
Emir Malovic & Subhash C. PandeyÂÂ
Plasticity markers in the human brain associated with rapid antidepressants
Joshua S. Siegel & Ginger E. NicolÂÂ
The role of racial discrimination in dissociation and interoceptive dysfunction
Negar Fani & Sahib S. KhalsaÂÂ
Sleep disturbance in substance use disorders: the orexin (hypocretin) system as an emerging pharmacological target
Utsav Gyawali & Morgan H. JamesÂÂ
The double-edged sword of the double-stranded break
Robert J. Fenster & Junghyup SuhÂÂ
Beyond the hypothalamus: roles for insulin as a regulator of neurotransmission, motivation, and feeding
Carrie R. Ferrario & Julie E. FinnellÂÂ
Unexpected circuit-level tradeoffs in human stress resilience
Jennifer S. Stevens & Alyssa R. RoecknerÂÂ
Echoes of ancient DNA in living modern humans affect risk for neuropsychiatric disease and brain structure and function of networks subserving higher-order cognition
Michael D. Gregory & Karen F. BermanÂÂ
Real-time fMRI neurofeedback: the promising potential of brain-training technology to advance clinical neuroscience
Stephan F. Taylor & Meghan E. MartzÂÂ
Shaping long-range functional connectivity through prefrontal interneuron plasticity
David A. Kupferschmidt & Joshua A. GordonÂÂ
Single-cell transcriptional profiling in brain reward structures
Jeremy J. Day & Keri MartinowichÂÂ
Blood-based biomarkers for suicide in depression: moving a step closer to prediction
Firoza Mamdani & Adolfo SequeiraÂÂ
Epigenetic aging in psychiatry: clinical implications and therapeutic opportunities
Camila N. C. Lima & Gabriel R. FriesÂÂ
How much is too much? New evidence associating low levels of prenatal alcohol exposure with brain differences in children
Catherine Lebel & Xiangyu LongÂÂ
Reaching for the unreachable: low intensity focused ultrasound for non-invasive deep brain stimulation
Noah S. Philip & Amanda R. ArulpragasamÂÂ
Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions
Nicole A. Crowley & Scott H. MedinaÂÂ
The promise of 3,4-methylenedioxymethamphetamine (MDMA) in combination with prolonged exposure therapy for posttraumatic stress disorder
Barbara O. Rothbaum & Jessica L. Maples-KellerÂÂ
Synaptic plasticity of the orbitofrontal cortex in obesity
Lauren T. Seabrook & Stephanie L. BorglandÂÂ
