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The effect of inhaling mother’s breast milk odor on the behavioral responses to pain caused by hepatitis B vaccine in preterm infants: a randomized clinical trial
Zahra Akbarian Rad, Parvin Aziznejadroshan, Adeleh Saebi Amiri, Hemmat Gholinia Ahangar & Zahra Valizadehchari
doi : 10.1186/s12887-021-02519-0
BMC Pediatrics volume 21, Article number: 61 (2021)
Nowadays, it is generally assumed that non-pharmacologic pain relief in preterm infants is an important measure to consider. Research findings suggest that familiar odors have soothing effects for neonates. The aim of this study was to compare the effect of maternal breast milk odor (MBMO) with that of another mother’s breast milk odor (BMO) on the behavioral responses to pain caused by hepatitis B (HB) vaccine injection in preterm infants.
Anesthesia, sex and miscarriage history may influence the association between cesarean delivery and autism spectrum disorder
Ye Yang, Jingjing Lin, Xiaozi Lu, Guanglei Xun, Renrong Wu, Yamin Li, Jianjun Ou, Yidong Shen, Kun Xia & Jingping Zhao
doi : 10.1186/s12887-021-02518-1
BMC Pediatrics volume 21, Article number: 62 (2021)
To explore the association between cesarean section (CS) and risk of autism spectrum disorder (ASD), and evaluate the possible factors influencing this association.
Biologic therapy is associated with a mild decrease in the rate of hospitalizations in pediatric IBD
Gil Berkovitch, Shlomi Cohen, Ronit Lubetzky, Dana Singer & Anat Yerushalmy-Feler
doi : 10.1186/s12887-021-02526-1
BMC Pediatrics volume 21, Article number: 63 (2021)
The effect of biologic therapy on the incidence of inflammatory bowel disease (IBD)-related hospitalizations is controversial. The high efficacy of biologic agents is weighted against potential therapy-related adverse events, however, there are no data on the effect of biologic therapy on the indications for hospitalization in IBD. We aimed to evaluate the impact of biologic therapy on the indications and rate of hospitalization in pediatric IBD.
Brazilian Portuguese version of the Amsterdam infant stool scale: a valid and reliable scale for evaluation of stool from children up to 120?days old
Laura Cantisano de Deus Silva, Priscila Monaro Bianchini, Erika Veruska Paiva Ortolan, Juliana Fattori Hamamoto, Rosemary Fermiano, Rebeca Mayara Padilha Rego, Jo?o César Lyra, Marc Alexander Benninga & Pedro Luiz Toledo de Arruda Lourenç?o
doi : 10.1186/s12887-021-02527-0
BMC Pediatrics volume 21, Article number: 64 (2021)
For newborns and infants wearing diapers the difficulties in characterizing the appearance of the stool are significant, since the changes in consistency, quantity, and color of the stool are higher than in other age groups. The Amsterdam Infant Stool Scale (AISS) was created and validated in 2009, providing a specific tool for the evaluation of the stool of children up to 120?days old. However, to be used in clinical practice and scientific investigations in Brazil, it is mandatory to perform the translation and cross-cultural adaptation process for Brazilian Portuguese language. Thus, we aim to perform the translation and cross-cultural adaptation of AISS into Brazilian Portuguese and to evaluate the psychometric properties of the translated version.
Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study
Caiying Wang, Huimin Zhang, Yanlan Zhang, Lin Xu, Min Miao, Hongling Yang, Yuhuan Liu, Shuxin He & Lin Pang
doi : 10.1186/s12887-021-02507-4
BMC Pediatrics volume 21, Article number: 65 (2021)
The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding of the clinical characteristics and risk factors for severe pertussis, and more effective measures should be taken to reduce the incidence and mortality of pertussis in young infants
Association of neural tube defects with congenital abnormalities of the urogenital system in a Chinese cohort
Zhi-Hua Hong, Dong-Hui Jin, Xiao-Jian Yuan, Yang Zhao, Hou-Wei Lin & Jie Chen
doi : 10.1186/s12887-021-02492-8
BMC Pediatrics volume 21, Article number: 66 (2021)
This study aimed to retrospectively analyze the correlation between congenital abnormality of the urogenital system and various factors in children with neural tube defects (NTDs).
Selumetinib side effects in children treated for plexiform neurofibromas: first case reports of peripheral edema and hair color change
Francesco Baldo, Andrea Magnolato, Egidio Barbi & Irene Bruno
doi : 10.1186/s12887-021-02530-5
BMC Pediatrics volume 21, Article number: 67 (2021)
Plexiform neurofibromas (PNs) are congenital tumors that affect around 50?% of the subjects with neurofibromatosis type 1. Despite being histologically benign, PNs can grow rapidly, especially in the pediatric age, and cause severe morbidities. In the past, various therapeutic approaches have been proposed to treat these masses, none of which obtained valuable results. Selumetinib, an inhibitor of mitogen-activated protein kinase (MEK) 1 and 2, has been the first molecule to demonstrate the ability of tackling the growth of PNs. The drug’s most common side effects, which usually are mild or moderate, include gastrointestinal symptoms (diarrhea, abdominal pain), dermatologic manifestations (maculo-papular and acneiform rash, paronychia, mucositis), and various laboratory test abnormalities (elevation of creatine kinase and aminotransferase).
Concurrent and predictive validity of the infant motor profile in infants at risk of neurodevelopmental disorders
Riccardo Rizzi, Valentina Menici, Maria Luce Cioni, Alessandra Cecchi, Veronica Barzacchi, Elena Beani, Matteo Giampietri, Giovanni Cioni, Giuseppina Sgandurra & the Clinical CareToy-R Consortium
doi : 10.1186/s12887-021-02522-5
BMC Pediatrics volume 21, Article number: 68 (2021)
Preterm infants and infants with perinatal brain injury show a higher incidence of neurodevelopmental disorders (NDD). The Infant Motor Profile (IMP) is a clinical assessment which evaluates the complexity of early motor behaviour. More data are needed to confirm its predictive ability and concurrent validity with other common and valid assessments such as the Alberta Infant Motor Scale (AIMS) and Prechtl’s General Movement Assessment (GMA). The present study aims to evaluate the concurrent validity of the IMP with the AIMS, to assess its association with the GMA, to evaluate how the IMP reflects the severity of the brain injury and to compare the ability of the IMP and the AIMS to predict an abnormal outcome in 5-month-old infants at risk of NDD.
Mycoplasma hominis meningitis in an extremely preterm newborn: a case report
Najmus Sehr Ansari, Elizabeth Asztalos & Asaph Rolnitsky
doi : 10.1186/s12887-021-02532-3
BMC Pediatrics volume 21, Article number: 69 (2021)
Mycoplasma Hominis is a micro-organism which is a part of the human genitourinary tract flora. Neonates are susceptible to acquire this pathogen either in utero or through vertical transmission. In rare cases, it may cause central nervous system infections with severe morbidity and mortality in preterm and term neonates.
Four mutations in MITF, SOX10 and PAX3 genes were identified as genetic causes of waardenburg syndrome in four unrelated Iranian patients: case report
Safoura Zardadi, Sima Rayat, Maryam Hassani Doabsari, Aliagha Alishiri, Mohammad Keramatipour, Zeynab Javanfekr Shahri & Saeid Morovvati
doi : 10.1186/s12887-021-02521-6
BMC Pediatrics volume 21, Article number: 70 (2021)
Waardenburg syndrome (WS) is a rare genetic disorder. The purpose of this study was to investigate clinical and molecular characteristics of WS in four probands from four different Iranian families.
Cognitive functioning in Deaf children using Cochlear implants
Fidaa Almomani, Murad O. Al-momani, Soha Garadat, Safa Alqudah, Manal Kassab, Shereen Hamadneh, Grant Rauterkus & Richard Gans
doi : 10.1186/s12887-021-02534-1
BMC Pediatrics volume 21, Article number: 71 (2021)
Cognitive abilities like language, memory, reasoning, visualization, and perceptual functioning shape human action and are considered critical to the successful interaction with the environment. Alternatively, hearing loss can disrupt a child’s ability to communicate, and negatively impact cognitive development. Cochlear implants (CI) restore auditory input thereby supporting communication and may enhance cognitive performance. This study compares general cognitive development after cochlear implantation (2017–2019) in two groups of Jordanian children implanted earlier (age:4–6?years, N?=?22) and later (7–9?years, N?=?16) to the development of randomly selected normal hearing peers (N?=?48).
Wolman’s disease presenting with secondary hemophagocytic lymphohistiocytosis: a case report from Saudi Arabia and literature review
Fahad Alabbas, Ghaleb Elyamany, Talal Alanzi, Tahani Bin Ali, Fatma Albatniji & Huda Alfaraidi
doi : 10.1186/s12887-021-02541-2
BMC Pediatrics volume 21, Article number: 72 (2021)
Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal syndrome that is characterized by strong activation of the immune system from hyperinflammatory cytokines. Symptoms of HLH patients include fever, hepatosplenomegaly, cytopenia, and hyperferritinemia. Inherited HLH is classified as primary, whereas secondary HLH (sHLH) occurs when acquired from non-inherited reasons that include severe infection, immune deficiency syndrome, autoimmune disorder, neoplasm, and metabolic disorder. Wolman’s disease (WD) is a rare and fatal infantile metabolic disorder caused by lysosomal acid lipase deficiency, that exhibits similar clinical signs and symptoms as HLH. This paper reports the case of an infant diagnosed with WD and who presented with sHLH.
Association of screen time with parent-reported cognitive delay in preschool children of Kerala, India
Jijo Joseph John, Reny Joseph, Alice David, Ann Bejoy, Kalyan Varghese George & Lisa George
doi : 10.1186/s12887-021-02545-y
BMC Pediatrics volume 21, Article number: 73 (2021)
Screen use is increasing rapidly among preschool children and excess screen use in these children has been associated with cognitive side effects and speech delay. We undertook this study to estimate the risk associated with screen time in children, parental supervision, and parent-reported cognitive development among preschool children aged 2–5?years.
Association between head circumference at two years and second and fifth year cognition
Beena Koshy, Manikandan Srinivasan, Timiri Palani Murugan, Anuradha Bose, Pamela Christudoss, Venkata Raghava Mohan, Sushil John, Reeba Roshan & Gagandeep Kang
doi : 10.1186/s12887-021-02543-0
BMC Pediatrics volume 21, Article number: 74 (2021)
Head circumference (HC) measurement is routinely not performed in early childhood and there is conflicting information about its utility in literature. The current study analyses the association between HC at two years of age and cognition at two and five years of age.
Nonresection management of the pancreas for grade III and IV blunt pancreatic injuries in children: a single center’s experience
Dan Zhang, Jiayu Yan, Sarah Tan Siyin, Wenbo Pang & Yajun Chen
doi : 10.1186/s12887-021-02535-0
BMC Pediatrics volume 21, Article number: 75 (2021)
The treatment of high-grade (III/IV/V) blunt pancreatic injuries remains controversial. The study aims to summarize and evaluate nonresection management of the pancreas for grade III and IV blunt pancreatic injuries in children.
Diagnosis of latent tuberculosis infection among pediatric household contacts of Iranian tuberculosis cases using tuberculin skin test, IFN- ? release assay and IFN-?-induced protein-10
Roxana Mansour Ghanaie, Abdollah Karimi, Leila Azimi, Seddon James, Mahshid Nasehi, Abolfazl Panahi Mishkar, Mahnaz Sheikhi, Fatemeh Fallah, Sedigheh Rafiei Tabatabaei & Seyedeh Mahsan Hoseini-Alfatemi
doi : 10.1186/s12887-021-02524-3
BMC Pediatrics volume 21, Article number: 76 (2021)
Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of this high-risk group, mainly because of resource limitations. We aimed to evaluate the prevalence of LTBI among pediatric household contacts of TB cases in two high-burden provinces in Iran.
Lipid profile of Mexican children with Down syndrome
Silvestre Garcia-de la Puente, Karla A. Flores-Arizmendi, Mar?a J. Delgado-Montemayor & Tania T. Vargas-Robledo
doi : 10.1186/s12887-021-02542-1
BMC Pediatrics volume 21, Article number: 77 (2021)
Down syndrome (DS) is associated with various congenital anomalies and metabolic alterations, such as dyslipidemias, that can lead to cardiovascular disease in adulthood. This study was designed to describe the lipid concentrations and the frequency of dyslipidemias in children with DS.
Factors associated with diarrhoea and acute respiratory infection in children under-5?years old in Ghana: an analysis of a national cross-sectional survey
Paschal Awingura Apanga & Maxwell Tii Kumbeni
doi : 10.1186/s12887-021-02546-x
BMC Pediatrics volume 21, Article number: 78 (2021)
Diarrhoea and acute respiratory infection (ARI) are major causes of morbidity and mortality in children under-5?years old in Ghana. The aim of the study was to assess factors associated with diarrhoea and ARI in children under-5?years old.
Genetic variants and physical activity interact to affect bone density in Hispanic children
Ruixue Hou, Shelley A. Cole, Mariaelisa Graff, Yujie Wang, Karin Haack, Sandra Laston, Nitesh R. Mehta, Roman J. Shypailo, Margaret L. Gourlay, Anthony G. Comuzzie, Kari E. North, Nancy F. Butte & Venkata Saroja Voruganti
doi : 10.1186/s12887-021-02537-y
BMC Pediatrics volume 21, Article number: 79 (2021)
Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study.
Rapid component of excess post-exercise oxygen consumption of children of different weight status after playing active video games
Caio Victor Sousa, Jungyun Hwang, Herbert Gustavo Simoes, Kyung Jin Sun & Amy Shirong Lu
doi : 10.1186/s12887-021-02528-z
BMC Pediatrics volume 21, Article number: 80 (2021)
Excess post-exercise oxygen consumption (EPOC) of children could indicate the potential of an exercise therapy to treat or prevent obesity. However, EPOC as a result of playing active video games (AVG) has been poorly investigated. Therefore, we aimed to investigate the rapid component of EPOC of children with healthy weight and overweight/obesity (according to their BMI percentile) after playing AVGs that feature predominately upper body (UB) and whole-body (WB) movement.
Burden and consequence of birth defects in Nepal-evidence from prospective cohort study
Prajwal Paudel, Avinash K. Sunny, Rejina Gurung, Abhishek Gurung, Honey Malla, Netra B. Rana, Nawaraj KC, Ram Narayan Chaudhary & Ashish KC
doi : 10.1186/s12887-021-02525-2
BMC Pediatrics volume 21, Article number: 81 (2021)
Every year an estimated 7.9 million babies are born with birth defect. Of these babies, more than 3 million die and 3.2 million have disability. Improving nationwide information on prevalence of birth defect, risk factor and consequence is required for better resource allocation for prevention, management and rehabilitation. In this study, we assess the prevalence of birth defect, associated risk factors and consequences in Nepal.
Sleep-related difficulties in healthy children and adolescents
Christiane Lewien, Jon Genuneit, Christof Meigen, Wieland Kiess & Tanja Poulain
doi : 10.1186/s12887-021-02529-y
BMC Pediatrics volume 21, Article number: 82 (2021)
As sleep-related difficulties are a growing public health concern, it is important to gain an overview of the specific difficulty areas of the most vulnerable individuals: children. The current descriptive study presents the prevalence of sleep-related difficulties in two large samples of healthy children and adolescents and outlines the effects of age, gender, and socioeconomic status (SES) on various sleep-related difficulties.
Oral feeding for infants and children receiving nasal continuous positive airway pressure and high flow nasal cannula: a systematic review
Angie Canning, Sally Clarke, Sarah Thorning, Manbir Chauhan & Kelly A Weir
doi : 10.1186/s12887-021-02531-4
BMC Pediatrics volume 21, Article number: 83 (2021)
The aim of this systematic review was to determine whether introduction of oral feeding for infants and children receiving nasal continuous positive airway pressure (nCPAP) or high flow nasal cannula (HFNC) respiratory support facilitates achievement of full oral feeding without adverse effects, compared to no oral feeding (NPO; nil per oral) on CPAP or HFNC.
Attainment of smiling and walking in infancy associates with developmental delays at school entry in moderately-late preterm children: a community-based cohort study
Nienke H. van Dokkum, Sijmen A. Reijneveld, Arend F. Bos & Marlou L. A. de Kroon
doi : 10.1186/s12887-021-02548-9
BMC Pediatrics volume 21, Article number: 84 (2021)
Moderately-late preterm (MLP) children (gestational age [GA] 32–36?weeks) are followed-up within community services, which often use developmental milestones as indicators of delay. We aimed to examine associations of parental report of smiling-age and walking-age with developmental delay upon school entry for MLP and full-term children.
Role of umbilical cord C-peptide levels in early prediction of hypoglycemia in infants of diabetic mothers
Ahlam M. Saber, Magdy A. Mohamed, Abdelrahim A. Sadek & Ramadan A. Mahmoud
doi : 10.1186/s12887-021-02547-w
BMC Pediatrics volume 21, Article number: 85 (2021)
Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia.
Preliminary evidence for an influence of exposure to polycyclic aromatic hydrocarbons on the composition of the gut microbiota and neurodevelopment in three-year-old healthy children
Wei Zhang, Zhongqing Sun, Qian Zhang, Zhitao Sun, Ya Su, Jiahui Song, Bingling Wang & Ruqin Gao
doi : 10.1186/s12887-021-02539-w
BMC Pediatrics volume 21, Article number: 86 (2021)
During the second and third year after birth the gut microbiota (GM) is subjected to important development. The polycyclic aromatic hydrocarbon (PAH) exposure could influence the GM in animal and early postnatal exposure is associated with neurodevelopment disorder in children. This study was designed to explore the possible influence of the polycyclic aromatic hydrocarbons (PAHs) on the composition of the gut microbiota (GM) and neurodevelopment in a sample of 38 healthy children at the age of 3?years.
The diagnostic threshold of Cornell assessment of pediatric delirium in detection of postoperative delirium in pediatric surgical patients
Hong Hong, Chao Guo, Zhi-Hua Liu, Bo-Jie Wang, Shu-Zhe Zhou, Dong-Liang Mu & Dong-Xin Wang
doi : 10.1186/s12887-021-02538-x
BMC Pediatrics volume 21, Article number: 87 (2021)
Cornell assessment of pediatric delirium (CAPD) showed advantage in diagnosis of pediatric delirium in Chinese critically ill patients. But its performance in surgical patients is still unclear. The present study was designed to validate the diagnostic performance of CAPD in surgical pediatric patients.
Time series analysis of the relationship between diarrhea in children and Rota 2 vaccine in the Fanteakwa District of the eastern region of Ghana
James Atampiiga Avoka, Elvis J. Dun-Dery, Issah Seidu, Armel N. E. Abou, Paul Twene, Isaac Obeng Tandoh & Frederick Dun-Dery
doi : 10.1186/s12887-021-02540-3
BMC Pediatrics volume 21, Article number: 88 (2021)
Rotavirus is considered the main causal factor of severe gastroenteritis among infants and children globally. The association with severe rotavirus infection is mostly worse among the least developed countries, mainly due to inadequate access to medical care and poverty. This study was conducted to determine the seasonal effects in respect of diarrhea cases in children, the association between diarrhea cases and Rota2 vaccine in the Fanteakwa District of the Eastern Region of Ghana.
Quality improvement strategies to improve inpatient management of small and sick newborns across All Babies Count supported hospitals in rural Rwanda
David Tuyisenge, Samuel Byiringiro, M. Louise Manirakiza, Robert G. Mutsinzi, Alphonse Nshimyiryo, Merab Nyishime, Lisa R. Hirschhorn, Francois Biziyaremye, Joseph Gitera, Kathryn Beck & Catherine M. Kirk
doi : 10.1186/s12887-021-02544-z
BMC Pediatrics volume 21, Article number: 89 (2021)
Neonatal mortality contributes to nearly half of child deaths globally and the majority of these deaths are preventable. Poor quality of care is a major driver of neonatal mortality in low- and middle-income countries. The All Babies Count (ABC) intervention was designed to reduce neonatal mortality through provision of equipment and supplies, training, mentorship, and data-driven quality improvement (QI) with peer-to-peer learning through learning collaborative sessions (LCS). We aim to describe the ABC scale-up in seven rural district hospitals from 2017 to 2019 focusing on the QI strategies implemented in hospital neonatal care units (NCUs) and the resultant neonatal care outcomes.
Comparison of different detection methods for Mycoplasma pneumoniae infection in children with community-acquired pneumonia
Mingyu Tang, Dong Wang, Xing Tong, Yufen Wu, Jing Zhang, Lei Zhang, Yong Yin & Qing Cao
doi : 10.1186/s12887-021-02523-4
BMC Pediatrics volume 21, Article number: 90 (2021)
Due to the lack of a sensitive, specific and rapid detection method, aetiological diagnosis of pneumonia caused by Mycoplasma pneumoniae (M. pneumoniae, MP) is a constantly challenging issue. This retrospective study aimed to compare the diagnostic methods for Mycoplasma pneumoniae in children and evaluate their values.
Bedside upper gastrointestinal series in the neonatal intensive care unit
Choeum Kang, Haesung Yoon, Hyun Joo Shin, Ho Sun Eun, Kook In Park & Mi-Jung Lee
doi : 10.1186/s12887-021-02554-x
BMC Pediatrics volume 21, Article number: 91 (2021)
In neonatal intensive care unit (NICU) patients with intubation status, fluoroscopic evaluation for the bowel is limited. This study was to evaluate the utility of bedside upper gastrointestinal (UGI) series with delayed radiographs (DR) for assessing duodenojejunal junction (DJJ) and small bowel passage in NICU patients with nonspecific bowel ultrasonography and contrast enema findings.
Etiological and predictive factors of pediatric urticaria in an emergency context
Leelawadee Techasatian, Pariwat Phungoen, Jitjira Chaiyarit & Rattapon Uppala
doi : 10.1186/s12887-021-02553-y
BMC Pediatrics volume 21, Article number: 92 (2021)
Urticaria is common in pediatric population and is caused by various etiologies which usually differ among different age groups. The different etiologies require different management strategies. Thus, understanding detailed of the etiologies of urticaria in children would help pediatricians to perform appropriate initial treatment.
Correction to: Optimization of pediatric CT scans in a developing country
Eddy Fotso Kamdem, Odette Ngano Samba, Clemence Alla Takam, Alain Jervé Fotue, Serge Abogo & Cornellius Lukong Fai
doi : 10.1186/s12887-021-02555-w
BMC Pediatrics volume 21, Article number: 93 (2021)
Nutritional education during rehabilitation of children 6–24?months with acute malnutrition, under unavailability of therapeutic/supplementary foods: a retrospective study in rural Angola
Andrea Pietravalle, Martina Scilipoti, Francesco Cavallin, Magda Lonardi, Ivo Makonga Tshikamb, Claudia Robbiati, Daniele Trevisanuto & Giovanni Putoto
doi : 10.1186/s12887-021-02560-z
BMC Pediatrics volume 21, Article number: 94 (2021)
Dietary counseling can play an important role in managing child malnutrition but is often inadequate or absent. Moreover, little emphasis is given to the usefulness of local available foods in the rehabilitation of malnourished children. This study aimed to evaluate the adherence and effectiveness of nutritional education during rehabilitation of children (6–24?months) with acute malnutrition, in a setting of unavailability of therapeutic/supplementary foods.
The impact of COVID-19 pandemic outbreak on education and mental health of Chinese children aged 7–15?years: an online survey
Zhongren Ma, Sakinah Idris, Yinxia Zhang, Liu Zewen, Amaad Wali, Yunpeng Ji, Qiuwei Pan & Zulqarnain Baloch
doi : 10.1186/s12887-021-02550-1
BMC Pediatrics volume 21, Article number: 95 (2021)
The emerging of psychological problems triggered by COVID-19 particularly in children have been extensively highlighted and emphasized, but original research in this respect is still lagging behind. Therefore, we designed this study to evaluate the impact of COVID-19 pandemic on mental health and the effectiveness and attitudes towards online education among Chinese children aged 7–15?years.
Clinical signs associated with earlier diagnosis of children with autism Spectrum disorder
Nachum Sicherman, Jimmy Charite, Gil Eyal, Magdalena Janecka, George Loewenstein, Kiely Law, Paul H. Lipkin, Alison R. Marvin & Joseph D. Buxbaum
doi : 10.1186/s12887-021-02551-0
BMC Pediatrics volume 21, Article number: 96 (2021)
The objective of this study is to gain new insights into the relationship between clinical signs and age at diagnosis.
Electrocardiographic pattern of apparently healthy African adolescent athletes in Nigeria
Ogochukwu J. Sokunbi, Christy A. N. Okoromah, Ekanem N. Ekure, Olajide A. Olawale & Wuraola S. Eke
doi : 10.1186/s12887-021-02557-8
BMC Pediatrics volume 21, Article number: 97 (2021)
Strategies to prevent sudden cardiac death (SCD) among young athletes have become topical worldwide and unrecognized cardiac pathology has been identified as a leading cause. Black ethnicity has been reported as an independent predictor of abnormal electrocardiography (ECG) findings among athletes and the frequency and significance of training-related ECG findings versus findings suggestive of an underlying pathology in the young African athletes is crucial.
Clinical profile and outcome of acute organophosphate poisoning in children of Upper Egypt: a cross-sectional study
Khaled A. Abdel Baseer, Eman Fathala Gad & Yaser F. Abdel Raheem
doi : 10.1186/s12887-021-02563-w
BMC Pediatrics volume 21, Article number: 98 (2021)
Organophosphates are one of the most common agents of poisoning in developing countries including Egypt. Due to lack of data about characteristics of organophosphates poisoning in our localities, we aimed to evaluate its clinical pattern and factors affecting outcome.
Neurobehavioural and cognitive effects of prenatal exposure to organochlorine compounds in three year old children
Griet Vermeir, Adrian Covaci, Nik Van Larebeke, Greet Schoeters, Vera Nelen, Gudrun Koppen & Mineke Viaene
doi : 10.1186/s12887-021-02533-2
BMC Pediatrics volume 21, Article number: 99 (2021)
We report data of a Belgian observational prospective cohort study regarding cognitive and behavioural development until the age of 36?months in relation to internal exposure to organochlorine pollutants [sum of polychlorinated biphenyls (sum PCB), dioxin-like activity, PCB118, PCB170, hexachlorobenzene (HCB) and p,p’-dichlorodiphenyldichloroethylene (DDE)] measured in cord blood.
Study protocol: baby-OSCAR trial: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial
Samir Gupta, Edmund Juszczak, Pollyanna Hardy, Nimish Subhedar, Jonathan Wyllie, Wilf Kelsall, Sunil Sinha, Sam Johnson, Tracy Roberts, Elisabeth Hutchison, Justine Pepperell, Louise Linsell, Jennifer L. Bell, Kayleigh Stanbury, Marketa Laube, Clare Edwards & David Field on behalf of the ‘The Baby-OSCAR Collaborative Group’
doi : 10.1186/s12887-021-02558-7
BMC Pediatrics volume 21, Article number: 100 (2021)
The question of whether to treat patent ductus arteriosus (PDA) early or wait until symptoms appear remains high on the research agenda for neonatal medicine. Around 7000 extremely preterm babies under 29?weeks’ gestation are born in the UK every year. In 40% of cases the PDA will fail to close spontaneously, even by 4?months of age. Untreated PDA can be associated with several serious and life-threatening short and long-term complications. Reliable data to support clinical decisions about PDA treatment are needed to prevent serious complications in high risk babies, while minimising undue exposure of infants. With the availability of routine bedside echocardiography, babies with a large PDA can be diagnosed before they become symptomatic.
Gliosarcoma in patients under 20?years of age. A clinicopathologic study of 11 cases and detailed review of the literature
Nasir Ud Din, Hira Ishtiaq, Shabina Rahim, Jamshid Abdul-Ghafar & Zubair Ahmad
doi : 10.1186/s12887-021-02556-9
BMC Pediatrics volume 21, Article number: 101 (2021)
Gliosarcoma is a rare variant of IDH- wild type glioblastoma with both glial and mesenchymal differentiation. It accounts for approximately 2% of glioblastomas and has a poor prognosis similar to that of classic glioblastoma. It is seen mostly between 40 and 60?years of age with a mean age over 50?years. Pediatric gliosarcoma is even rarer than gliosarcoma in adults. We describe the clinicopathological features of gliosarcoma in patients under 20?years of age and determine whether there are significant differences from gliosarcoma in adults. We also present detailed review of published literature on pediatric gliosarcoma.
Combination of umbilical cord mesenchymal stem cells and standard immunosuppressive regimen for pediatric patients with severe aplastic anemia
Yang Lan, Fang Liu, Lixian Chang, Lipeng Liu, Yingchi Zhang, Meihui Yi, Yuli Cai, Jing Feng, Zhibo Han, Zhongchao Han & Xiaofan Zhu
doi : 10.1186/s12887-021-02562-x
BMC Pediatrics volume 21, Article number: 102 (2021)
Defects of bone marrow mesenchymal stem cells (BM-MSCs) in proliferation and differentiation are involved in the pathophysiology of aplastic anemia (AA). Infusion of umbilical cord mesenchymal stem cells (UC-MSCs) may improve the efficacy of immunosuppressive therapy (IST) in childhood severe aplastic anemia (SAA).
