European Heart Journal

Head-up tilt test (TT) has been used for >50?years to study heart rate/blood pressure adaptation to positional changes, to model responses to haemorrhage, to assess orthostatic hypotension, and to evaluate haemodynamic and neuroendocrine responses in congestive heart failure, autonomic dysfunction, and hypertension. During these studies, some subjects experienced syncope due to vasovagal reflex.

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Precision Medicine and cardiac channelopathies: when dreams meet reality

Massimiliano Gnecchi, Luca Sala, Peter J Schwartz

doi : 10.1093/eurheartj/ehab007

Volume 42, Issue 17, 1 May 2021, Pages 1661–1675,

Precision Medicine (PM) is an innovative approach that, by relying on large populations’ datasets, patients’ genetics and characteristics, and advanced technologies, aims at improving risk stratification and at identifying patient-specific management through targeted diagnostic and therapeutic strategies. Cardiac channelopathies are being progressively involved in the evolution brought by PM and some of them are benefiting from these novel approaches, especially the long QT syndrome. Here, we have explored the main layers that should be considered when developing a PM approach for cardiac channelopathies, with a focus on modern in vitro strategies based on patient-specific human-induced pluripotent stem cells and on in silico models.

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Predicted benefit of an implantable cardioverter-defibrillator: the MADIT-ICD benefit score

Arwa Younis, Jeffrey J Goldberger, Valentina Kutyifa, Wojciech Zareba, Bronislava Polonsky

doi : 10.1093/eurheartj/ehaa1057

Volume 42, Issue 17, 1 May 2021, Pages 1676–1684,

The benefit of prophylactic implantable cardioverter-defibrillator (ICD) is not uniform due to differences in the risk of life-threatening ventricular tachycardia (VT)/ventricular fibrillation (VF) and non-arrhythmic mortality. We aimed to develop an ICD benefit prediction score that integrates the competing risks.

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Precision prevention with ICDs: can a simple score improve patient selection?

David R Okada, Hugh Calkins

doi : 10.1093/eurheartj/ehaa1102

Volume 42, Issue 17, 1 May 2021, Pages 1685–1686,

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Robustness and relevance of predictive score in sudden cardiac death for patients with Brugada syndrome

Vincent Probst, Thomas Goronflot, Soraya Anys, Romain Tixier, Jean Briand

doi : 10.1093/eurheartj/ehaa763

Volume 42, Issue 17, 1 May 2021, Pages 1687–1695,

Risk stratification of sudden cardiac arrest (SCA) in Brugada syndrome (Brs) remains the main challenge for physicians. Several scores have been suggested to improve risk stratification but never replicated. We aim to investigate the accuracy of the Brs risk scores.

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Risk stratification in Brugada syndrome: the challenge of the grey zone

Pietro Delise

doi : 10.1093/eurheartj/ehaa1100

Volume 42, Issue 17, 1 May 2021, Pages 1696–1697,

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Serial assessment of biomarkers and the risk of stroke or systemic embolism and bleeding in patients with atrial fibrillation in the ENGAGE AF-TIMI 48 trial

Kazuma Oyama, Robert P Giugliano, David D Berg, Christian T Ruff, Petr Jarolim

doi : 10.1093/eurheartj/ehab141

Volume 42, Issue 17, 1 May 2021, Pages 1698–1706,

We investigated whether patients with atrial fibrillation (AF) demonstrate detectable changes in biomarkers including high-sensitivity troponin T (hsTnT), N-terminal B-type natriuretic peptide (NT-proBNP), and growth differentiation factor-15 (GDF-15) over 12?months and whether such changes from baseline to 12?months are associated with the subsequent risk of stroke or systemic embolic events (S/SEE) and bleeding.

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