Journal of the American College of Cardiology




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doi : 10.1016/S0735-1097(21)00154-6

Volume 77, Issue 8, 2 March 2021, Page e217

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Contents

doi : 10.1016/S0735-1097(21)00155-8

Volume 77, Issue 8, 2 March 2021, Pages e219-e222

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3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure

Michael J.MackMDaJoAnnLindenfeldMDbWilliam T.AbrahamMDcSaibalKarMDdeD. ScottLimMDfJacob M.MishellMDgBrian K.WhisenantMDhPaul A.GrayburnMDiMichael J.RinaldiMDjSamir R.KapadiaMDkVivekRajagopalMDlIan J.SarembockMBChB, MDmAndreasBriekeMDnJason H.RogersMDoSteven O.MarxMDpDavid J.CohenMD, MScqNeil J.WeissmanMDrsGregg W.StoneMDtCOAPT Investigators

doi : 10.1016/j.jacc.2020.12.047

Volume 77, Issue 8, 2 March 2021, Pages 1029-1040

In the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial, transcatheter mitral valve repair (TMVr) resulted in fewer heart failure hospitalizations (HFHs) and lower mortality at 24 months in patients with heart failure (HF) with mitral regurgitation (MR) secondary to left ventricular dysfunction compared with guideline-directed medical therapy (GDMT) alone.

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Crossover in COAPT: Does This Extend the Reach of TMVr for Treating Functional MR??

Jeremiah P.DeptaMD, MPHSaDeepak L.BhattMD, MPHb

doi : 10.1016/j.jacc.2021.01.001

Volume 77, Issue 8, 2 March 2021, Pages 1041-1043

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Prognostic Value of Coronary CT Angiography in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes

Klaus F.KofoedMD, DmScabThomasEngstr?mMD, DmScaPer E.SigvardsenMDaJesper J.LindeMD, PhDaChristianTorp-PedersenMD, DmSccMartinade KnegtMD, PhDaPeter R.HansenMD, DmSccThomasFritz-HansenMD, PhDcJanBechMD, PhDdMereteHeitmannMD, PhDdOlav W.NielsenMD, DmScdDanH?fstenMD, PhDaJ?rgen T.KühlMD, DmSceIlan E.RaymondMD, PhDeOle P.KristiansenMD, DmScdIda H.SvendsenMD, PhDdM.H.Dom?nguez Vall-LamoraMD, PhDdCharlotteKragelundMD, PhDc…Lars V.K?berMD, DmSca

doi : 10.1016/j.jacc.2020.12.037

Volume 77, Issue 8, 2 March 2021, Pages 1044-1052

Severity and extent of coronary artery disease (CAD) assessed by invasive coronary angiography (ICA) guide treatment and may predict clinical outcome in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS).

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Coronary Computed Tomography Angiography to Triage Patients With Non–ST-Segment Elevation Acute Coronary Syndrome?

Michelle C.WilliamsMBChB, PhDabMarc R.DweckMBChB, PhDaDavid E.NewbyBM, PhDab

doi : 10.1016/j.jacc.2020.12.050

Volume 77, Issue 8, 2 March 2021, Pages 1053-1056

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Association of Hypertensive Disorders of Pregnancy With Left Ventricular Remodeling Later in Life

Malamo E.CountourisMDaFlordeliza S.VillanuevaMDaKathryn L.BerlacherMD, MSaJo?o L.CavalcanteMDbW. TonyParksMDcJanet M.CatovPhD, MSd

doi : 10.1016/j.jacc.2020.12.051

Volume 77, Issue 8, 2 March 2021, Pages 1057-1068

Hypertensive disorders of pregnancy (HDP) are associated with short-term cardiac structure and function abnormalities, but later life changes are not well studied.

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Long-Term Left Ventricular Remodeling After Hypertensive Disorders of Pregnancy: Beyond the Hype?

Melinda B.DavisMD

doi : 10.1016/j.jacc.2021.01.006

Volume 77, Issue 8, 2 March 2021, Pages 1069-1072

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Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell–Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium

GentaroIkedaMD, PhDaMichelle R.SantosoBSaYukoTadaMD, PhDaAlbert M.LiABbEvgeniyaVaskovaPhDaJi-HyeJungPhDaConnorO’BrienMDaElizabethEganMD, PhDcJiangbinYePhDbPhillip C.YangMDa

doi : 10.1016/j.jacc.2020.12.060

Volume 77, Issue 8, 2 March 2021, Pages 1073-1088

Mitochondrial dysfunction results in an imbalance between energy supply and demand in a failing heart. An innovative therapy that targets the intracellular bioenergetics directly through mitochondria transfer may be necessary.

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Cardiac Mitochondrial Transplantation: The Force Awakens?

BorjaIb??ezMD, PhDabcRocioVillena-GutierrezBSca

doi : 10.1016/j.jacc.2021.01.017

Volume 77, Issue 8, 2 March 2021, Pages 1089-1092

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Comparison of Management Strategies for Neonates With Symptomatic Tetralogy of Fallot

Bryan H.GoldsteinMDabcdChristopher J.PetitMDeAthar M.QureshiMDfgCourtney E.McCrackenPhDeMichael S.KellemanMS, MSPHeGeorge T.NicholsonMDhMark A.LawMDiJeffery J.MeadowsMDjJeffrey D.ZampiMDkShabanaShahanavazMDlChristopher E.MascioMDmnPaul J.ChaiMDeJennifer C.RomanoMDkSarosh P.BatlivalaMDcdShiraz A.MaskatiaMDopIvor B.AsztalosMD, MSCEmnAlicia M.KamshehMDmnSteven J.HealanMD, MSCIhJustin D.SmithMDkR. AllenLigonMDeJoelle A.PettusMPH, MSeSarinaJumaMPHeJames E.B.RaulstonMDiKrissie M.HockMSN, RN, CNLiAmy L.PajkMBAcdLindsay F.EilersMDfgHala Q.KhanBSfgTaylor C.MerrittRN, BSNlMatthewCanterMETlStephanJuergensenMDjFatuma-AyaanRinderknechtBAjHollyBauser-HeatonMD, PhDeAndrew C.GlatzMD, MSCEmnq

doi : 10.1016/j.jacc.2020.12.048

Volume 77, Issue 8, 2 March 2021, Pages 1093-1106

Neonates with tetralogy of Fallot and symptomatic cyanosis (sTOF) require early intervention.

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Primary Versus Staged Neonatal Repair of Symptomatic Tetralogy of Fallot: Time to Randomize??

Christoph P.HornikMD, PhD, MPH

doi : 10.1016/j.jacc.2020.12.043

Volume 77, Issue 8, 2 March 2021, Pages 1107-1109

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Malaria and the Heart: JACC State-of-the-Art Review

ShylaGuptaaNaomiGazendamaJuan Mar?aFarinaMDbClaraSaldarriagaMDcIvanMendozaMDdRicardoL?pez-SantiMDeGonzalo EmanuelPérezMDbManuelMart?nez-SellésMDfAdrianBaranchukMDa

doi : 10.1016/j.jacc.2020.12.042

Volume 77, Issue 8, 2 March 2021, Pages 1110-1121

As one of the tropical diseases, malaria is endemic in developing countries. Severe malaria, mainly caused by the Plasmodium falciparum parasite, can result in life-threatening complications. Traditionally, cardiac involvement has not been included as a frequent cause of morbidity and mortality. This could be due to under-reporting or underdiagnosing. Specific cardiovascular (CV) complications include electrocardiogram abnormalities, myocarditis, pericarditis, pericardial effusion, ischemic disease, and heart failure. According to the data analyzed, CV manifestations can lead to severe consequences. Possible theories related to the pathophysiological mechanisms related to CV compromise include an imbalanced pro-inflammatory cytokine response and/or erythrocyte sequestration by increased cytoadherence to endothelium. Although there is a paucity of data regarding cardiac manifestations of malaria, an algorithm for appropriate use of diagnostic tools to assess cardiac involvement has been developed in this paper. Furthermore, it is important to note that typical antimalarial treatment regimens can have fatal cardiac side-effects.

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Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week

VigyanBangMDa?SarjuGanatraMDa?Sachin P.ShahMDaSourbha S.DaniMDaTomas G.NeilanMD, MPHbPaaladineshThavendiranathanMD, SMcFrederic S.ResnicMDaThomas C.PiemonteMDaAnaBaracMDdRushinPatelMBBSaAjaySharmaMDaRohanParikhMDaGhulam M.ChaudhryMDaMarkVeselyMDeSalim S.HayekMDfMonikaLejafDavidVenesyMDaRichardPattenMDaDanielLenihanMDgAnjuNohriaMDhLeslie T.CooperMDi

doi : 10.1016/j.jacc.2020.11.074

Volume 77, Issue 8, 2 March 2021, Pages 1122-1134

Giant cell myocarditis is a rare, often rapidly progressive and potentially fatal, disease due to T-cell lymphocyte-mediated inflammation of the myocardium that typically affects young and middle-aged adults. Frequently, the disease course is marked by acute heart failure, cardiogenic shock, intractable ventricular arrhythmias, and/or heart block. Diagnosis is often difficult due to its varied clinical presentation and overlap with other cardiovascular conditions. Although cardiac biomarkers and multimodality imaging are often used as initial diagnostic tests, endomyocardial biopsy is required for definitive diagnosis. Combination immunosuppressive therapy, along with guideline-directed medical therapy, has led to a paradigm shift in the management of giant cell myocarditis resulting in an improvement in overall and transplant-free survival. Early diagnosis and prompt management can decrease the risk of transplantation or death, which remain common in patients who present with cardiogenic shock.

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Does Patient-Physician Gender Concordance Influence Patient Perceptions or Outcomes?

Emily S.LauMDaSharonne N.HayesMDbAnnabelle SantosVolgmanMDcKathrynLindleyMDdCarl J.PepineMDeMalissa J.WoodMDaAmerican College of Cardiology Cardiovascular Disease in Women Section

doi : 10.1016/j.jacc.2020.12.031

Volume 77, Issue 8, 2 March 2021, Pages 1135-1138

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Technology and the Pandemic: A Tool We Must Wield to Maintain Our Humanity

ValentinFusterMD, PhD

doi : 10.1016/j.jacc.2021.01.022

Volume 77, Issue 8, 2 March 2021, Pages 1139-1140

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Second Decline in Admissions With Heart Failure and Myocardial Infarction During the COVID-19 Pandemic

JianhuaWuPhDMamas A.MamasDPhilMark A.de BelderMDJohn E.DeanfieldPhDChris P.GalePhD

doi : 10.1016/j.jacc.2020.12.039

Volume 77, Issue 8, 2 March 2021, Pages 1141-1143

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Left Posterior Fascicular Block and Increased Risk of Sudden Cardiac Death in Young People

LeonardoCal?MDRobertaDella BonaMD, PhDAnnamariaMartinoMD, PhDCinziaCrescenziMDGermanaPanattoniMD, PhDGiuliad’AmatiMD, PhDFiorenzoGaitaMDRuggieroMangoMD, PhDLuigiSciarraMDMikaelLaredoMD, MSc

doi : 10.1016/j.jacc.2020.12.033

Volume 77, Issue 8, 2 March 2021, Pages 1143-1145

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Assessment of Nonstenotic Carotid Plaques

NishitaSinghMDJohannaOspelMDMayankGoyalMD, PhD

doi : 10.1016/j.jacc.2020.11.075

Volume 77, Issue 8, 2 March 2021, Pages 1145-1146

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Inflammation in Nonstenotic Carotid Artery Plaques: One More Factor to Consider?

GeorgiosBenetosMDMariaDrakopoulouMDGeorgiosOikonomouMDKonstantinosTsioufisMDKonstantinosToutouzasMD

doi : 10.1016/j.jacc.2020.11.076

Volume 77, Issue 8, 2 March 2021, Pages 1146-1147

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Reply: Comparison of Different Plaque Imaging Techniques to Detect Complicated Carotid Artery Plaques

AnnaKopczakMDAndreasSchindlerMDMartinDichgansMDTobiasSaamMD

doi : 10.1016/j.jacc.2020.12.038

Volume 77, Issue 8, 2 March 2021, Pages 1147-1148

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