Diabetes




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سفارش

Targeting the Pancreatic α-Cell to Prevent Hypoglycemia in Type 1 Diabetes

Julia K. Panzer; Alejandro Caicedo

doi : 10.2337/dbi20-0048

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COVID-19–Induced New-Onset Diabetes: Trends and Technologies

Ahmed A. Metwally; Pranav Mehta; Brian S. Johnson; Anvith Nagarjuna; Michael P. Snyder

doi : 10.2337/dbi21-0029

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Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Jihoon Shin; Shinichiro Toyoda; Shigeki Nishitani; Atsunori Fukuhara; Shunbun Kita; Michio Otsuki; Iichiro Shimomura

doi : 10.2337/db20-1094

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Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function

Jee Hyung Sohn; Yul Ji; Chang-Yun Cho; Hahn Nahmgoong; Sangsoo Lim; Yong Geun Jeon; Sang Mun Han; Ji Seul Han; Isaac Park; Hyun-Woo Rhee; Sun Kim; Jae Bum Kim

doi : 10.2337/db21-0272

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Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

Maria M. Glavas; Ann Y. Lee; Ian Miao; Fan Yang; Majid Mojibian; Shannon M. O’Dwyer; Timothy J. Kieffer

doi : 10.2337/db21-0310

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Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes: Results of the Randomized Controlled Prediabetes Lifestyle Intervention Study (PLIS)

Andreas Fritsche; Robert Wagner; Martin Heni; Kostantinos Kantartzis; Jürgen Machann; Fritz Schick; Rainer Lehmann; Andreas Peter; Corinna Dannecker; Louise Fritsche; Vera Valenta; Renate Schick; Peter Paul Nawroth; Stefan Kopf; Andreas F.H. Pfeiffer; Stefan Kabisch; Ulrike Dambeck; Michael Stumvoll; Matthias Blüher; Andreas L. Birkenfeld; Peter Schwarz; Hans Hauner; Julia Clavel; Jochen Seißler; Andreas Lechner; Karsten Müssig; Katharina Weber; Michael Laxy; Stefan Bornstein; Annette Schürmann; Michael Roden; Martin Hrabe de Angelis; Norbert Stefan; Hans-Ulrich Häring

doi : 10.2337/db21-0526

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Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1

Christian de Wendt; Lena Espelage; Samaneh Eickelschulte; Christian Springer; Laura Toska; Anna Scheel; Awovi Didi Bedou; Tim Benninghoff; Sandra Cames; Torben Stermann; Alexandra Chadt; Hadi Al-Hasani

doi : 10.2337/db21-0587

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Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes

Sharmaine Thirunavukarasu; Nicholas Jex; Amrit Chowdhary; Imtiaz Ul Hassan; Sam Straw; Thomas P. Craven; Miroslawa Gorecka; David Broadbent; Peter Swoboda; Klaus K. Witte; Richard M. Cubbon; Hui Xue; Peter Kellman; John P. Greenwood; Sven Plein; Eylem Levelt

doi : 10.2337/db21-0270

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Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9

Ryan P. Ceddia; Dianxin Liu; Fubiao Shi; Mark K. Crowder; Sumita Mishra; David A. Kass; Sheila Collins

doi : 10.2337/db21-0100

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Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice

Eunjin Oh; Erika M. McCown; Miwon Ahn; Pablo A. Garcia; Sergio Branciamore; Shanshan Tang; De-Fu Zeng; Bart O. Roep; Debbie C. Thurmond

doi : 10.2337/db21-0170

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The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice

Nathalie Jouvet; Khalil Bouyakdan; Scott A. Campbell; Cindy Baldwin; Shannon E. Townsend; Maureen A. Gannon; Vincent Poitout; Thierry Alquier; Jennifer L. Estall

doi : 10.2337/db21-0147

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Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms

Neetu Srivastava; Hao Hu; Anthony N. Vomund; Orion J. Peterson; Rocky L. Baker; Kathryn Haskins; Luc Teyton; Xiaoxiao Wan; Emil R. Unanue

doi : 10.2337/db21-0513

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Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect

Virginia M. Stone; Marta Butrym; Minna M. Hankaniemi; Amir-Babak Sioofy-Khojine; Vesa P. Hytönen; Heikki Hyöty; Malin Flodström-Tullberg

doi : 10.2337/db21-0193

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CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes

Marie Eliane Azoury; Fatoumata Samassa; Mijke Buitinga; Laura Nigi; Noemi Brusco; Aïsha Callebaut; Matthieu Giraud; Magali Irla; Ana Ines Lalanne; Alexia Carré; Georgia Afonso; Zhicheng Zhou; Barbara Brandao; Maikel L. Colli; Guido Sebastiani; Francesco Dotta; Maki Nakayama; Decio L. Eizirik; Sylvaine You; Sheena Pinto; Mark J. Mamula; Yann Verdier; Joelle Vinh; Soren Buus; Chantal Mathieu; Lut Overbergh; Roberto Mallone

doi : 10.2337/db21-0259

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Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

Andrea Vecchione; Tatiana Jofra; Jolanda Gerosa; Kimberly Shankwitz; Roberta Di Fonte; Giuseppe Galvani; Elio Ippolito; Maria Pia Cicalese; Andrew R. Schultz; Howie R. Seay; Mariagrazia Favellato; Giulia Milardi; Angela Stabilini; Francesca Ragogna; Pauline Grogan; Eleonora Bianconi; Andrea Laurenzi; Amelia Caretto; Rita Nano; Raffaela Melzi; Nichole Danzl; Emanuele Bosi; Lorenzo Piemonti; Alessandro Aiuti; Todd Brusko; Constantinos Petrovas; Manuela Battaglia; Georgia Fousteri

doi : 10.2337/db21-0091

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Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study

Jennifer E. Nyland; Nazia T. Raja-Khan; Kerstin Bettermann; Philippe A. Haouzi; Douglas L. Leslie; Jennifer L. Kraschnewski; Leslie J. Parent; Patricia Sue Grigson

doi : 10.2337/db21-0385

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Diabetes and the Risk of Long-term Post-COVID Symptoms

César Fernández-de-las-Peñas; Carlos Guijarro; Juan Torres-Macho; María Velasco-Arribas; Susana Plaza-Canteli; Valentín Hernández-Barrera; José A. Arias-Navalón

doi : 10.2337/db21-0329

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The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes

Emily K. Sims; David Cuthbertson; Kevan C. Herold; Jay M. Sosenko

doi : 10.2337/db21-0519

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Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism

Ruifang Li-Gao; David A. Hughes; Jan B. van Klinken; Renée de Mutsert; Frits R. Rosendaal; Dennis O. Mook-Kanamori; Nicholas J. Timpson; Ko Willems van Dijk

doi : 10.2337/db21-0397

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Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

Qing-Rong Liu; Min Zhu; Pingbo Zhang; Caio H. Mazucanti; Nicholas S. Huang; Doyle L. Lang; Qinghua Chen; Pavan Auluck; Stefano Marenco; Jennifer F. O’Connell; Luigi Ferrucci; Chee W. Chia; Josephine M. Egan

doi : 10.2337/db21-0198

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