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JCD Editorial—February 2022
Michael H. Gold MD
doi : 10.1111/jocd.14750
Volume 21, Issue 2 p. 419-419
Androgenetic alopecia and COVID-19: Is there a clinical connection?
Moein Baghani,Mohammad Reza Pourani,Sayyed Mojtaba Nekooghadam,Davood Ommi,Alireza Fatemi,Fahimeh Abdollahimajd,Hamideh Moravvej
doi : 10.1111/jocd.14670
Volume 21, Issue 2 p. 420-425
During the coronavirus disease 2019 (COVID-19) outbreak, multiple studies showed higher rates of severe infection in adults and specifically in male patients, which may be related to differences in androgen receptor (AR) expression. Androgenetic alopecia (AGA) is one of the AR expression manifestations.
Granulomatous reaction at PRP/Fat injection sites after recovering from SARS-Co-V2: A case report
Pinar Incel Uysal MD,Omer Gunhan MD
doi : 10.1111/jocd.14669
Volume 21, Issue 2 p. 426-428
A new-onset vitiligo following the inactivated COVID-19 vaccine
Sema Koç Y?ld?r?m MD
doi : 10.1111/jocd.14677
Volume 21, Issue 2 p. 429-430
Retrospective evaluation of patients with chronic spontaneous urticaria using omalizumab during the COVID-19 pandemic
Sema Koç Y?ld?r?m MD,Neslihan Demirel Ö?üt MD,Ece Erba?c? MD
doi : 10.1111/jocd.14725
Volume 21, Issue 2 p. 431-434
Omalizumab (OMZ) is a monoclonal anti-immunoglobulin E antibody used in patients with chronic spontaneous urticaria (CSU). The data about using OMZ during the coronavirus disease 19 (COVID-19) pandemic are limited. The aim of this study was to evaluate the status of having COVID-19 and relationships between COVID-19, vaccination, and urticaria symptoms of CSU patients on OMZ.
Pigmented purpuric dermatosis after BNT162B2 mRNA COVID-19 vaccine administration
Mehmet Fatih Atak MD,Banu Farabi MD,Mehmet Berati Kalelioglu MD,Babar K. Rao MD
doi : 10.1111/jocd.14607
Volume 21, Issue 2 p. 435-437
Myths and media in oral collagen supplementation for the skin, nails, and hair: A review
Andrea M. Rustad BA,Melissa A. Nickles BA,Jenna E. McKenney BA,Sara N. Bilimoria MS,Peter A. Lio MD
doi : 10.1111/jocd.14567
Volume 21, Issue 2 p. 438-443
As a key component of the hair, skin, and nails, there is strong consumer interest in the dermatologic efficacy of oral collagen supplementation. Oral supplementation with collagen peptides has increased in popularity in recent years.
Non-invasive diagnostic techniques in pigmentary skin disorders and skin cancer
Yashdeep Singh Pathania MD,Zoe Apalla MD,Gabriel Salerni MD,Anant Patil MD,Stephan Grabbe MD,Mohamad Goldust MD
doi : 10.1111/jocd.14547
Volume 21, Issue 2 p. 444-450
Diagnosis of pigmentary skin disorders, pre-cancerous and cancerous skin diseases is traditionally relied on visual assessment. The most widely applied invasive diagnostic technique is the skin biopsy. There have been significant technological advances in non-invasive diagnostic methods for skin disorders.
Application of omics technologies in dermatological research and skin management
Jianbiao He BS,Yan Jia PhD
doi : 10.1111/jocd.14100
Volume 21, Issue 2 p. 451-460
"Omics" are usually based on the use of high-throughput analysis methods for global analysis of biological samples and the discovery of biomarkers, and may provide new insights into biological phenomena. Over the last few years, the development of omics technologies has considerably accelerated the pace of dermatological research.
A review of combined treatments for melasma involving energy-based devices and proposed pathogenesis-oriented combinations
Joseph N. Mehrabi,Efrat Bar-Ilan MD,Shehadeh Wasim MD,Amir Koren MD,Lior Zusmanovitch MD,Fares Salameh MD,Gila Isman Nelkenbaum MD,Tamir Horovitz MD,Eyal Zur RPh,Ting Song Lim MD,Jacob Mashiah MD,Ofir Artzi MD
doi : 10.1111/jocd.14110
Volume 21, Issue 2 p. 461-472
Melasma is an acquired disorder of hyperpigmentation, affecting a million individuals worldwide. Energy-based devices (EBDs) employed to treat melasma include various types of lasers, intense pulsed light (IPL), and radiofrequency (RF). Recent studies have attempted to address recalcitrant and recurring melasma by combining energy-based devices with topical or oral medications.
Use of topical anti-inflammatory and antineoplastic agents in the treatment of young-aged actinic cheilitis: A systematic review
Cristianne Kalinne Santos Medeiros PhD, MSc, DDS,Glória Maria de França PhD, MSc, DDS,Jabes Gennedyr da Cruz Lima MSc, DDS,Juliana Campos Pinheiro PhD, MSc, DDS,Dennys Ramon de Melo Fernandes Almeida PhD, MSc, DDS,Pedro Paulo de Andrade Santos PhD, MSc, DDS
doi : 10.1111/jocd.14118
Volume 21, Issue 2 p. 473-481
Several treatments have been used to reduce inflammation and to reverse epithelial alterations in actinic cheilitis (AC).
Pathophysiology, clinical findings, and management of Fox-Fordyce disease: A systematic review
Antoine Salloum MD,Youssef Bouferraa MD,Nagham Bazzi MD,Maroun Bou Zerdan MD,Joanna Abi Chebl MD,Thomas Chu MD,Julien Bachour MD,Anthony Benedetto DO
doi : 10.1111/jocd.14135
Volume 21, Issue 2 p. 482-500
Fox-Fordyce (FFD), also known as apocrine military, is an uncommon chronic inflammation of the apocrine sweat glands. It is characterized by pruritic, papular eruptions in apocrine-gland-bearing regions. FFD was described a century ago, but the exact pathogenesis of the disease and the management are not well understood.
Shikimic acid in the light of current knowledge
Mirella Batory PhD,Helena Rotsztejn MD, PhD
doi : 10.1111/jocd.14136
Volume 21, Issue 2 p. 501-505
Shikimic acid (SA) has been mainly used in the pharmaceutical industry for production of drugs, however, recently it has also appeared in the world of cosmetics. So far, there have not been many publications on cosmetics containing SA or research studies on the compound, especially those that would involve testing cosmetic products on subjects. The main source of SA is star anise. The recommended concentration of SA in cosmetic preparations ranges between 1 and 5%. The pH of a 5% solution of SA in water is 3. SA at a concentration of 5% has a similar exfoliative effect to that of 50% glycolic acid. It shows antiviral, exfoliating, deodorizing, anti-acne, anti-dandruff, whitening and moisturizing activity. It also regulates the amount of secreted sebum, moreover, it has antibacterial, anti-inflammatory, hair-growth stimulating, anti-aging effect and antifungal properties.
The therapeutic effects in patients with rosacea: how do we evaluate them?
Shasha Zhao MBBS,Meng Wang MBBS,Yuan Zhou MBBS,Yan Yan MD
doi : 10.1111/jocd.14713
Volume 21, Issue 2 p. 506-512
Rosacea is a common, chronic skin disorder with negative impacts on physical health and social function. The response to therapy plays a critical factor in determining the duration of treatment and developing new medicines. However, it is challenging to assess the efficacy due to its complicated clinical characteristics and nonspecific histopathological findings.
Essential oils used in dermocosmetics: Review about its biological activities
Cassandra Cunha,Helena Margarida Ribeiro,Márcio Rodrigues,André R.T.S. Araujo
doi : 10.1111/jocd.14652
Volume 21, Issue 2 p. 513-529
Currently, the demand for the use of constituents of natural origin in cosmetic formulations in detriment of synthetic compounds is noticeable. Several studies assess the potential of essential oils when incorporated into various cosmetic formulations and study their biological activities. This work intends to prepare a literature review on essential oils tested in dermocosmetic formulations and whose biological activities were evaluated through in vitro and/or in vivo tests. The main objectives for this study were as follows: to identify the essential oils that have been used in cosmetic formulations; and compile information on the main biological activities tested in cosmetic formulations.
Diagnosing onychomycosis: A step forward?
Aditya K. Gupta MD, PhD,Deanna C. Hall PhD
doi : 10.1111/jocd.14681
Volume 21, Issue 2 p. 530-535
There are a number of available methods for diagnosing onychomycosis, but more emerge as technology advances. This review briefly discusses the common diagnostic methods, the use of artificial intelligence (AI) as a diagnostic tool in dermatology as a whole, and then examines research on the use of AI for diagnosing onychomycosis. The studies discussed implemented convolutional neural networks (CNNs) to examine datasets of images of entire nails or histological images and then used the information learned from those datasets to make a diagnostic decision of onychomycosis or not.
Emerging topical drug delivery approaches for the treatment of Atopic dermatitis
Shruti Ghosalkar MPharm,Prabha Singh PhD,Padmini Ravikumar PhD
doi : 10.1111/jocd.14685
Volume 21, Issue 2 p. 536-549
Atopic dermatitis is a chronic, relapsing skin inflammation disease that generally affects 20% of children and 1–3% of adults. It is characterized by pruritus, inflammatory skin lesions, and skin barrier defect. The pillar treatment is topical therapies that have shown great adherence and incredible results in alleviating symptoms of atopic dermatitis. Topical corticosteroids and calcineurin inhibitors have shown improvement in the symptoms of atopic dermatitis but have certain side effects. There is need to develop new therapies or novel drug delivery approaches which can overcome drawbacks of the conventional formulation and increase the therapeutic efficacy.
OnabotulinumtoxinA from lines to facial reshaping: A new Italian consensus report
Massimo Signorini MD,Salvatore Piero Fundarò MD,Dario Bertossi MD,Maurizio Cavallini MD,Pierfrancesco Cirillo MD,Guglielmo Natuzzi MD,Sandro Quartucci MD,Chantal Sciuto MD,Mariagrazia Patalano MD,Gloria Trocchi MD
doi : 10.1111/jocd.14728
Volume 21, Issue 2 p. 550-563
Botulinum neurotoxin type A is the most widely used nonsurgical treatment for esthetic improvement of the face and neck. In 2015, an Italian consensus panel met to discuss the optimal methods for using onabotulinumtoxinA. However, clinical practice continues to evolve and the original report is now considered obsolete.
Corrective treatment for tear trough deformity in a young population utilizing two-dimensional fat injections
Yongsheng Su MD,Jieguang Zhong MD,Shurong Lu PhD
doi : 10.1111/jocd.14708
Volume 21, Issue 2 p. 564-570
Tear trough deformity (TTD) is becoming a growing concern for those seeking facial rejuvenation, and various treatment strategies have been reported. Among treatment options is micro-autologous fat injection, which appears to be an effective approach to recontour the tear trough in the young. The study we present here investigated the reliability and effectiveness of two-dimensional fat injections (TDFI) in the treatment of young patients with TTD.
The selection of hyaluronic acid when treating with the nasolabial fold: A meta-analysis
Tong Peng MD,Wei-Jin Hong MD, PhD,Jun-Ren Fang MD,Sheng-Kang Luo MD, PhD
doi : 10.1111/jocd.14710
Volume 21, Issue 2 p. 571-579
Hyaluronic acid (HA) gel is a widely used dermal filler for the correction of facial volume loss. The relationship between the characteristics of HA and clinical efficacy remains unclear. The aim of this systematic review and meta-analysis was to compare the efficacy and safety of monophasic and biphasic HA in the treatment of nasolabial folds (NLFs).
Evaluation of the safety and effectiveness of intradermal administration of QR678 Neo® hair growth factor formulation: A phase-IV, open-label, single-arm multi-ethnicity clinical trial
Aayna Clinic MD,Annette Asper DNP, FNP-C, MSN,Apoorva Mittal MBBS, DO, MCH,Debraj Shome MD, FRCS, FACS, FAACS, MBA,Deepa Parbhoo MBBCh,James Thanzama MBBS, MD,Komal Doshi MDS,Neha Sachde MBBS, AAAM, MBA,Ridhima Gaunkar MDS,Rinky Kapoor MD,Rukshmani Thakkar MBA,Simal Sion MBBS, PG Dip, Mphil,Sushant Shetty MBBS, MD,Vaibhav Kumar MDS,Veena Parveen MBBS, DVD,Vivek Singhal MD
doi : 10.1111/jocd.14715
Volume 21, Issue 2 p. 580-589
Intradermal administration of QR678 Neo® hair re-growth factor formulation has already proven its effectiveness and safety in treating androgenetic alopecia and female pattern hair loss.
Platelet-Rich Plasma Treatment for Accelerated Androgenetic Alopecia Pattern Hair Loss After COVID-19 Infection: A Case Series
Akif ??lek MD,Engin Karaaslan MD,Sadullah ?im?ek MD,Funda Merve Çetin MD
doi : 10.1111/jocd.14721
Volume 21, Issue 2 p. 590-594
Hair-related manifestations such as alopecia areata or telogen effluvium were reported during COVID-19 disease. Accelerated hair loss with androgenetic alopecia (AGA) pattern or management has not been discussed before.
Is botulinum toxin a cause or a cure for headaches?
Didem Mullaaziz MD,Asl? Kaptano?lu MD
doi : 10.1111/jocd.14656
Volume 21, Issue 2 p. 595-599
Botulinum toxin is used in the treatment of headache as well as cosmetic indications. In recent years, headache cases have been encountered after botulinum toxin injections for cosmetic purposes. However, no clinical studies have been conducted on this seemingly paradoxical issue.
Validated 5-point photonumeric scales for the assessment of the jowls and chin
Rainer Pooth MD, PhD,Valentina Prinz BA, MBA,Mia Cajkovsky,Jeremy B. Green MD,Claudia A. Hernandez MD,Tatjana Pavicic MD, PhD,Daniel S. Mueller MD, MBA,Sonja Sattler MD,Heike Klepetko MD, PhD,Sabrina G. Fabi MD,Doris Day MD,Atchima Suwanchinda MD,Sebastian Cotofana MD, PhD,Konstantin Frank MD
doi : 10.1111/jocd.14661
Volume 21, Issue 2 p. 600-607
The objective of this investigation was to create and to examine the reproducibility and validity of 5-point photonumeric assessment scales that allow objective assessment of chin retrusion and jawline sagging using a digital and a live validation.
Topography of the deep temporal arteries and implications for performing safe aesthetic injections
Andreas Nikolis MD, MSc, FRCSC,Kaitlyn M. Enright MSc,Theodore Troupis MD, MSc, PhD,Michael Koutsilieris MD, PhD,Alexander J. Stratigos MD, PhD,Dimitrios Rigopoulos MD, PhD,Sebastian Cotofana MD, PhD
doi : 10.1111/jocd.14672
Volume 21, Issue 2 p. 608-614
Several studies have started investigating the safety of temporal rejuvenation using soft tissue fillers. However, as the temporal region is highly vascularized, adverse events due to intravascular injection are of primary concern. The scarcity of treatment guidelines to date have focused primarily on avoiding the superficial and middle temporal arteries. The aim of the present anatomical study was to describe the topography of the deep temporal arteries (DTAs) with reference to superficial landmarks, to aid clinicians who perform temporal injections.
PN-HPT® (Polynucleotides Highly Purified Technology) in facial middle third rejuvenation. Exploring the potential
Maurizio Cavallini MD,Carmen De Luca MD,Giovanni Prussia MD,Mauro Raichi MD
doi : 10.1111/jocd.14578
Volume 21, Issue 2 p. 615-624
Wasting of soft tissues leads to flattening and deflation of the aging midface skin. Polynucleotides Highly Purified Technology (PN-HPT®) demonstrated dermal hydration and elasticity as well as fibroblasts vitality and activity.
Temporary hair loss after injection of hyaluronic acid filler
Helga van den Elzen MD, PhD,Leonie Schelke MD, PhD,Peter Velthuis MD, PhD, BSc
doi : 10.1111/jocd.14453
Volume 21, Issue 2 p. 625-626
Compromised blood flow after filler injection is generally thought to result from intra-arterial obstruction.
Monophasic versus biphasic hyaluronic acid filler for correcting nasolabial folds: a systematic review and meta-analysis
Abdullah A. Ghaddaf,Yara E. Aljefri,Fahad A. Alharbi,Rahaf K. Sharif,Wejdan A. Alnahdi,Rasha Baaqeel MD, FRCSC
doi : 10.1111/jocd.14632
Volume 21, Issue 2 p. 627-635
Hyaluronic acid (HA) fillers are the most popular dermal fillers for wrinkle correction and facial rejuvenation. Recently, there has been an interest toward classifying HA fillers based on the cross-linking properties into monophasic (MHA) and biphasic (BHA) fillers. We aimed to compare the efficacy and safety outcomes between MHA and BHA fillers for the correction of nasolabial folds (NLFs).
Microfocused ultrasound with visualization: Consensus on safety and review of energy-based devices
Tatjana Pavicic MD, PhD,John R. Ballard PhD,Tatiana Bykovskaya MD,Niamh Corduff FRACS,Cyro Hirano MD,Je-Young Park MD,Alena Saromytskaya MD,Julia Sevi MD, PhD,Suyan Vasconcelos MD
doi : 10.1111/jocd.14666
Volume 21, Issue 2 p. 636-647
Microfocused ultrasound with visualization (MFU-V; Ultherapy®, Merz North America) is US Food and Drug Administration-cleared as a non-invasive procedure that lifts the soft tissue of the neck, submentum and brow, and improves lines and wrinkles on the upper chest. Several other energy-based devices are in use in countries outside the USA where they are marketed for indications similar to those of MFU-V, although published studies supporting these indications are limited and none of the other devices provides visualization or verification they reach the superficial musculoaponeurotic system.
Treatment protocols and efficacy of light and laser treatments in post-acne erythema
Rezvan Amiri MD,Maryam Khalili MD,Saman Mohammadi MD,Behzad Iranmanesh MD,Mahin Aflatoonian MD
doi : 10.1111/jocd.14729
Volume 21, Issue 2 p. 648-656
Post-acne erythema is described as erythema due to release of inflammatory cytokines, dilatation of microcapillaries within papillary dermis and thinning of epidermis. The erythema usually fades; however, it can persist for months.
Oral tranexamic acid, hydroquinone 4% and low-fluence 1064 nm Q-switched Nd:YAG laser for mixed melasma: Clinical and dermoscopic evaluation
Abdelaal M. Elkamshoushi MD,Doaa Romisy MD,Salma S. Omar MD
doi : 10.1111/jocd.14140
Volume 21, Issue 2 p. 657-668
Tranexamic acid (TA) can prevent melanocyte activation by various stimuli. Combining TA with either hydroquinone 4% or Q-switched Nd:YAG laser may be associated with greater improvement of melasma.
Dermoscopic changes in melanocytic nevi following hair removal laser: A prospective study
Maryam Nasimi MD,Vahide Lajevardi MD,Hamidreza Mahmoudi MD,Sadaf Heidari MD,Forugh Ghaedi MD
doi : 10.1111/jocd.14149
Volume 21, Issue 2 p. 669-673
Changes in the appearance of melanocytic nevi have been increasingly reported following hair removal lasers. This could be a source of anxiety in patients doing cosmetic hair removal lasers. Moreover, taking biopsy of any changed nevus following laser is not routinely practical. Therefore, this study was designed to describe dermoscopic changes happened on acquired junctional melanocytic nevi after photo-depilation methods.
Laser removal of tattoos in vegan and omnivore patients
Marta Fusano MD,Michela Gianna Galimberti MD,Pier Luca Bencini MD
doi : 10.1111/jocd.14134
Volume 21, Issue 2 p. 674-678
Clinical outcomes of tattoo removal vary widely among different patients; it is known that tattoo-related features (such as pigments' type or quality, the use of multicolored inks, tattoo location size, location, layering, and duration) and personal habits (as smoking or skin phototype) could influence the clinical response to treatment, the possible role of nutrition in affecting the laser treatment of tattoos has never been investigated.
A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Charussri Leeyaphan MD,Supenya Varothai MD,Suphattra Trakanwittayarak MD,Pranittra Suphatsathienkul MD,Suthasinee Pattaravadee BSc,Lalita Matthapan BSc,Waranyoo Prasong BSc,Kamonpan Lertrujiwanit BSc,Salisa Supcharoenkul BSc,Kanokvalai Kulthanan MD
doi : 10.1111/jocd.14125
Volume 21, Issue 2 p. 679-688
Intertrigo is an inflammatory skin-fold condition. Candida infections may occur concurrently or afterward. Topical corticosteroids may reduce inflammation but exacerbate Candida infections. The treatment is contentious.
Efficacy and tolerability of a detergent and care component for rosacea patients: A split-face, vehicle-controlled, randomized trial
Anne Guertler MD,Anne Charlotte Niesert MD,Klaus-Peter Wilhelm MD,Katrin Knuhr PhD,Marianne Brandt Dipl.-Phys,Lars E. French MD,Markus Reinholz MD
doi : 10.1111/jocd.14130
Volume 21, Issue 2 p. 689-697
The treatment of facial erythema and subjective symptoms of rosacea patients remains challenging in clinical practice. Cosmeceuticals, care components containing active ingredients such as phytochemicals, play a growing role in treatment plans. However, well-designed studies on their efficacy and limitations are widely missing.
Efficacy of handheld iontophoresis device in enhancing transdermal vitamin C delivery: A split-face clinical trial
Chadakan Yan MD,Janice Natasha C. Ng MD, DPDS,Rungsima Wanitphakdeedecha MD, MA, MSc
doi : 10.1111/jocd.14702
Volume 21, Issue 2 p. 698-706
The stratum corneum of the epidermis is the principal barrier in topical drug delivery. Currently, iontophoresis is incorporated in dermatology management to increase transdermal drug delivery.
Intralesional methotrexate versus triamcinolone acetonide for localized alopecia areata treatment: A randomized clinical trial
Mervat Hamdino MD,Rasha Aly El-Barbary MD,Hanan Mohammed Darwish MD
doi : 10.1111/jocd.14090
Volume 21, Issue 2 p. 707-715
Multiple therapeutic modalities are available for alopecia areata (AA) but still a challenging disease with variable severity, recurrence, and a major cosmetic concern.
Hyperbaric oxygen therapy acts as an alternative method in treating injection-induced nodules
Hayson Chenyu Wang,Haixin Zhai,Cheng Chen,Xinyu Ren,Xiaojun Wang
doi : 10.1111/jocd.14103
Volume 21, Issue 2 p. 716-719
Cosmetic injection-induced nodules are tricky to handle in the clinic.
Health knowledge and motives on tattooing: A community-based cross-sectional study in Greece
Venetia Notara MSc, PhD,Charalampos Gnardellis MSc, PhD,Evanthia Sakellari MSc, PhD,Pelagia Soultatou MSc, PhD,Eleni Petratou BSc,Kalliroi Dragomanovits BSc,Areti Lagiou MSc, PhD
doi : 10.1111/jocd.14119
Volume 21, Issue 2 p. 720-728
Tattooing is becoming an increasingly common trend mainly but not merely among the youth. However, the choice of ink body art is associated with an increase of dermatological complications.
Comparative sensory and instrumental analyses and principal components of commercial sunscreens
Mariane Massufero Vergilio MD,Andréa Carolina Pinheiro de Freitas B.Sc,Pedro Alves da Rocha-Filho PhD
doi : 10.1111/jocd.14113
Volume 21, Issue 2 p. 729-739
The initial contact of consumers when choosing sunscreens is through the trademark, packaging, perfume, and tactile feeling of the product, outlining the popular practice of sensory science.
In vitro and clinical evaluation of umbilical cord-derived mesenchymal stromal cell-conditioned media for hair regeneration
Caroline Mathen PhD,Wilfrid Dsouza MSc
doi : 10.1111/jocd.14114
Volume 21, Issue 2 p. 740-749
The field of regenerative medicine may present a non-drug, non-steroid, and non-invasive alternative toward addressing male and female pattern hair loss, a global concern.
Matriderm dermal substitute in the treatment of post traumatic hand’s fingertip tissue loss
Camillo Fulchignoni MD,Lorenzo Rocchi MD, PhD,Michele Cauteruccio MD,Gianfranco Merendi MD
doi : 10.1111/jocd.14115
Volume 21, Issue 2 p. 750-757
Treatment of fingers tissue loss is particularly challenging as it often necessitates advanced reconstructive techniques such as flaps or grafts, with esthetic and functional results that are not always as good as hoped for, with long healing times. Recently, along with tissue engineering development, numerous types of dermal substitute have been commercialized, with promising possibilities of treatment in finger tissue loss. In the author's unit, Matriderm® is the most commonly used dermal substitute. As described by the manufacturer, this scaffold is designed to be covered with a split-thickness skin graft. In using a two-step procedure, the authors realized that in most cases of fingertips injuries, at three weeks follow-up, the wound appeared in an advanced state of healing, which permitted to avoid grafting.
Predicting sun protection measures against skin diseases using machine learning approaches
Nahid Sultana PhD
doi : 10.1111/jocd.14120
Volume 21, Issue 2 p. 758-769
The substantial growth rate of skin cancer has necessitated adequate protection from solar radiation. Consequently, analyzing sun protection practices is an imperative research area in dermatology and pharmacology.
Psychiatric basics of alopecia areata in pediatric patients: Evaluation of emotion dysregulation, somatization, depression, and anxiety levels
Nihal Altunisik MD,Ilknur Ucuz MD,Dursun Turkmen MD
doi : 10.1111/jocd.14122
Volume 21, Issue 2 p. 770-775
Alopecia areata (AA) is a skin disease characterized by sudden-onset hair loss. The relationship between psychiatric status and AA has not been fully elucidated. The aim of this study was to evaluate emotion dysregulation, somatization, depression, and anxiety levels in children and adolescents with AA.
Evaluation of inner ear and hearing functions in lichen planus patients
Ahmet Yukkald?ran MD,Osman Erdogan MD,R?za Dundar MD,?sa An MD,Mustafa Aksoy MD
doi : 10.1111/jocd.14124
Volume 21, Issue 2 p. 776-780
Lichen planus (LP), which affects skin, nails, hair, and mucosal surfaces, is a chronic, autoimmune, and inflammatory disease, and autoimmune diseases may affect the inner ear.
Impact of polyphenols extracted from Tricholoma matsutake on UVB-induced photoaging in mouse skin
Minggao Deng Mme,Jing Wang PhD,Yong-Liang Li PhD,Hui-Xiong Chen Mme,Meiling Tai Mme,Lili Deng BE,Biao Che PhD,Zhi-Yun Du PhD,Chang-Zhi Dong Mme,Li Lin BE, MEc
doi : 10.1111/jocd.14127
Volume 21, Issue 2 p. 781-793
Despite Tricholoma matsutake has been used as natural health products with multiple medicinal properties, detailed information about its polyphenolic composition as sources of anti-photoaging agents remains to be determined.
Quality of life in young men with androgenetic alopecia: A mixed methods study
Josip Razum M.A,Tena Vukasovi? Hlupi? PhD
doi : 10.1111/jocd.14132
Volume 21, Issue 2 p. 794-801
Androgenetic alopecia (AGA) is related to adverse psychological consequences in young men, which is further accentuated by the astronomical growth of the hair transplant industry. However, a deeper insight into AGA and its impact on young men are lacking in the literature. Moreover, its impact is currently measured with general dermatological health-related quality of life questionnaires.
The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial
Joël Duperray Eng,Renaud Sergheraert Eng,Kunyanatt Chalothorn MSc,Preeyanuch Tachalerdmanee MSc,Fabrice Perin PhD
doi : 10.1111/jocd.14137
Volume 21, Issue 2 p. 802-813
Glutathione has become a potential skin-lightening ingredient after the discovery of its anti-melanogenic properties. Various mechanisms of action have been considered to explain this property, one of them being the skewing of the melanin synthesis pathway toward the production of lighter pheomelanin instead of darker eumelanin, consequently producing a lightening effect.
Novel bioactive formulation derived from the conditioned medium of mesenchymal stromal cells reduces under-eye dark circles in human volunteers
Samatha Bhat MSc, PhD,Muthukumar Amirthalingam MPharm, PhD,Sathish Pai Ballambat MD,Meghana Bhupasandra Vasudev DDVL,Pawan Kumar Gupta MD, PhD,Bharath Singh Padya MPharm,Srinivas Mutalik MPharm, PhD,Raviraja N. Seetharam MSc, MBA, PhD
doi : 10.1111/jocd.14145
Volume 21, Issue 2 p. 814-826
Under-eye dark circles are a common condition observed in dermatology practice. Mesenchymal stromal cell-derived conditioned medium (MSC-CM) contains an array of growth factors and cytokines reported to promote periorbital rejuvenation and may be useful in removing the dark circle around the eyes.
Prevention of chemically induced hair damage by means of treatment based on proteins and polysaccharides
Flávio Bueno Camargo Jr PhD,Marcos Magoiti Minami MSc,Marcos Roberto Rossan MSc,Wagner Vidal Magalhães MSc,Vitória Tonini Porto Ferreira BA,Patrícia Maria Berardo Gonçalves Maia Campos PhD
doi : 10.1111/jocd.14148
Volume 21, Issue 2 p. 827-835
There is currently a great interest not only in developing products for the protection and recovery of chemically damaged hair, but also in developing effective protocols to investigate the impact of chemical treatments and attest the efficacy of innovative hair care products. Among the most relevant cosmetic treatments for hair are bleaching and coloring, which have been shown to significantly impair mechanical and structural properties.
Comparison of the psychosocial impact of acne in adolescents and adults; body satisfaction, self-esteem, and quality of life
Birgül Özkesici Kurt
doi : 10.1111/jocd.14151
Volume 21, Issue 2 p. 836-843
Dermatological diseases, including acne vulgaris, have significant psychosocial effects on patients.
Exosomes derived from human adipose tissue-derived mesenchymal stem cells for the treatment of dupilumab-related facial redness in patients with atopic dermatitis: A report of two cases
Kui Young Park MD, PhD,Hye Sung Han MD,Jae Wan Park MD,Hyuck Hoon Kwon MD, PhD,Gyeong-Hun Park MD, PhD,Seong Jun Seo MD, PhD
doi : 10.1111/jocd.14153
Volume 21, Issue 2 p. 844-849
Atopic dermatitis is a chronic, pruritic, and inflammatory dermatosis that affects approximately 20% of children and 10% of adults worldwide. Dupilumab facial redness is gaining attention as additional cases are coming to light in the medical literature.
Subcutaneous emphysema after intralesional cryotherapy: An unusual complication
Tu?ba Falay Gür MD,Sevil Sava? Erdo?an MD,Cüneyt Kara MD,Sümeyre Seda Ertekin MD
doi : 10.1111/jocd.14159
Volume 21, Issue 2 p. 850-852
Intralesional cryotherapy (ILC) is a safe and well tolerated by the patient. Subcutaneous emphysema (SE) cases after spray and contact cryotherapy have been described; however, this complication has not been previously reported after ILC.
When hair loss is not just a cosmetic problem: Moth-eaten alopecia in secondary syphilis
Mario Vaccaro MD, PhD,Laura Macca MD,Paolo Custurone MD,Fabrizio Guarneri MD, PhD
doi : 10.1111/jocd.14105
Volume 21, Issue 2 p. 853-854
Successful treatment of long-standing alopecia totalis with intralesional methotrexate
Mohamed L. Elsaie MD,Mohamed S. Hasan MD
doi : 10.1111/jocd.14117
Volume 21, Issue 2 p. 855-856
The effect of hyperbaric oxygen therapy combined with hair transplantation surgery for the treatment of alopecia
Xinhang Dong MD,Xiaolei Jin MD
doi : 10.1111/jocd.14131
Volume 21, Issue 2 p. 857-858
The pathology under stretch marks? An elastosonography study
Sheila Veronese MEng,Alessandro Picelli MD, PhD,Andrea Zoccatelli MD,Alessandro Zadra MD,Niccolò Faccioli MD,Nicola Smania MD,Andrea Sbarbati MD, PhD
doi : 10.1111/jocd.14466
Volume 21, Issue 2 p. 859-864
Artificial intelligence for grading in acne vulgaris: current situation and prospect
Anqi Li MD,Rouyu Fang MD,Qiuning Sun MD
doi : 10.1111/jocd.14599
Volume 21, Issue 2 p. 865-866
Guidelines of care in cosmetic dermatology: From customized treatment for few to evidence-based treatments for many
Bianca Y. Kang BS,Sarah A. Ibrahim BA,Emily Poon PhD,Murad Alam MD, MBA, MSCI
doi : 10.1111/jocd.14684
Volume 21, Issue 2 p. 867-868
