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A Message From the Editor-In-Chief
Jacobson, Brian C. MD, MPH, FACG1
doi : 10.14309/ctg.0000000000000384
August 2021 - Volume 12 - Issue 8 - p e00384
The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men
Sikavi, Daniel R. MD1,2; Nguyen, Long H. MD, MS2,3,4; Haruki, Koichiro MD, PhD5; Ugai, Tomotaka MD, PhD5,6; Ma, Wenjie ScD2,3,4; Wang, Dong D. ScD4,7; Thompson, Kelsey N. PhD4,8; Yan, Yan PhD4; Branck, Tobyn MS4; Wilkinson, Jeremy E. PhD4; Akimoto, Naohiko MD, PhD5; Zhong, Rong PhD5; Lau, Mai Chan PhD5; Mima, Kosuke MD, PhD5; Kosumi, Keisuke MD, PhD5; Morikawa, Teppei MD, PhD5; Rimm, Eric B. ScD7; Garrett, Wendy S. MD, PhD8,9; Izard, Jacques PhD10,11; Cao, Yin ScD, MPH12,13; Song, Mingyang MBBS, ScD2,3,6,7; Huttenhower, Curtis PhD4,8,14; Ogino, Shuji MS, MD, PhD5,6,8,15; Chan, Andrew T. MD, MPH2,3,8,14
doi : 10.14309/ctg.0000000000000338
August 2021 - Volume 12 - Issue 8 - p e00338
We recently described the sulfur microbial diet, a pattern of intake associated with increased gut sulfur-metabolizing bacteria and incidence of distal colorectal cancer (CRC). We assessed whether this risk differed by CRC molecular subtypes or presence of intratumoral microbes involved in CRC pathogenesis (Fusobacterium nucleatum and Bifidobacterium spp.).
Use of Melatonin Is Associated With Lower Risk of Colorectal Cancer in Older Adults
Zhang, Naiqi MPhil1; Sundquist, Jan MD, PhD1,2,3; Sundquist, Kristina MD, PhD1,2,3; Ji, Jianguang MD, PhD1
doi : 10.14309/ctg.0000000000000396
August 2021 - Volume 12 - Issue 8 - p e00396
Preclinical evidence suggests that melatonin may affect cellular pathways involved in colorectal cancer (CRC). We sought to test whether melatonin use was associated with decreased risk of CRC using population-based data.
Detection of Circulating Tumor DNA Methylation in Diagnosis of Colorectal Cancer
Xu, Fei MD1; Yu, Shanshan MD2; Han, Junyi MD, PhD3; Zong, Ming MD2; Tan, Qi MD2; Zeng, Xin MD, PhD1; Fan, Lieying MD, PhD2
doi : 10.14309/ctg.0000000000000386
August 2021 - Volume 12 - Issue 8 - p e00386
Emerging evidence has demonstrated the potential of the circulating tumor DNA (ctDNA) methylation in the application of cancer diagnosis.
Optimizing Positivity Thresholds for a Risk-Adapted Screening Strategy in Colorectal Cancer Screening
Lu, Ming MBBS1; Wang, Le PhD2; Zhang, Yuhan MBBS1; Liu, Chengcheng PhD3,4; Lu, Bin MBBS1; Du, Lingbin MPH2; Liao, Xianzhen MD5; Dong, Dong MBBS6; Wei, Donghua MD7; Gao, Yi MD8; Shi, Jufang PhD1; Ren, Jiansong PhD1; Chen, Hongda PhD1; Dai, Min PhD1
doi : 10.14309/ctg.0000000000000398
August 2021 - Volume 12 - Issue 8 - p e00398
Risk-adapted screening combining the Asia-Pacific Colorectal Screening score, fecal immunochemical test (FIT), and colonoscopy improved the yield of colorectal cancer screening than FIT. However, the optimal positivity thresholds of risk scoring and FIT of such a strategy warrant further investigation.
Integrating Tumor Sequencing Into Clinical Practice for Patients With Mismatch Repair-Deficient Lynch Syndrome Spectrum Cancers
Dixon, Katherine PhD1; Asrat, Mary-Jill MSc2; Bedard, Angela C. MSc2; Binnington, Kristin MSc2; Compton, Katie MSc2; Cremin, Carol MSc2; Heidary, Nili MSc2; Lohn, Zoe MSc2; Lovick, Niki MSc2; McCullum, Mary MSN2; Mindlin, Allison MSc2; O'Loughlin, Melanie MGenCouns2; Petersen, Tammy MSc2; Portigal-Todd, Cheryl MSc2; Scott, Jenna MS1,2; St-Martin, Genevieve MSc2; Thompson, Jennifer MSc2; Turnbull, Ruth MSc2; Mung, Sze Wing BBA2; Hong, Quan MSc2; Bezeau, Marjorie MSc2,3; Bosdet, Ian PhD4; Tucker, Tracy PhD4; Young, Sean PhD4; Yip, Stephen MD, PhD4; Aubertin, Gudrun MD2,5; Blood, Katherine A. MD, PhD1,2,5; Nuk, Jennifer MSc1,2; Sun, Sophie MD, MSc2,6; Schrader, Kasmintan A. MBBS, PhD1,2,6
doi : 10.14309/ctg.0000000000000397
August 2021 - Volume 12 - Issue 8 - p e00397
Uninformative germline genetic testing presents a challenge to clinical management for patients suspected to have Lynch syndrome, a cancer predisposition syndrome caused by germline variants in the mismatch repair (MMR) genes or EPCAM.
Leveraging Fecal Microbial Markers to Improve the Diagnostic Accuracy of the Fecal Immunochemical Test for Advanced Colorectal Adenoma
Zhang, Yuhan MBBS1; Lu, Ming MBBS1; Lu, Bin MBBS1; Liu, Chengcheng MBBS1; Ma, Yiming PhD2; Liu, Li PhD3; Miao, Xiaoping PhD3; Qin, Junjie PhD4; Chen, Hongda PhD1; Dai, Min PhD1
doi : 10.14309/ctg.0000000000000389
August 2021 - Volume 12 - Issue 8 - p e00389
Fecal immunochemical tests (FITs) detect colorectal adenoma inefficiently. The gut microbiota participates in colorectal cancer development. We aimed to explore fecal microbial signatures for advanced adenomas and evaluate their diagnostic value and complementary capacity to FIT.
Adult-Onset Autoimmune Enteropathy in an European Tertiary Referral Center
van Wanrooij, Roy L.J. MD, PhD1; Neefjes-Borst, E. Andra MD2; Bontkes, Hetty J. PhD3; Schreurs, Marco W.J. PhD4; Langerak, Anton W. PhD4; Mulder, Chris J.J. MD, PhD1; Bouma, Gerd MD, PhD1
doi : 10.14309/ctg.0000000000000387
August 2021 - Volume 12 - Issue 8 - p e00387
Adult-onset autoimmune enteropathy (AIE) is a rare cause of severe chronic diarrhea because of small intestinal villous atrophy. We report on patients with adult-onset AIE in an European referral center.
History of Hepatic Encephalopathy Is Not a Contraindication to Transjugular Intrahepatic Portosystemic Shunt Placement for Refractory Ascites
Saab, Sammy MD, MPH1,2; Zhao, Matthew BS1; Asokan, Ishan MD, MSc1; Yum, Jung Jun BA2; Lee, Edward Wolfgang MD, PhD2,3
doi : 10.14309/ctg.0000000000000378
August 2021 - Volume 12 - Issue 8 - p e00378
The outcomes of transjugular intrahepatic portosystemic shunt (TIPS) placement in patients with hepatic encephalopathy (HE) are controversial. We studied the relationship of pre-TIPS HE in patients undergoing TIPS for refractory ascites on all-cause mortality and development of post-TIPS HE.
Simultaneous Recognition of Atrophic Gastritis and Intestinal Metaplasia on White Light Endoscopic Images Based on Convolutional Neural Networks: A Multicenter Study
Lin, Ne BM1; Yu, Tao BE2; Zheng, Wenfang BM1,3,4; Hu, Huiyi BE2; Xiang, Lijuan MM5; Ye, Guoliang MD6; Zhong, Xingwei BM7; Ye, Bin MD8; Wang, Rong MD9; Deng, Wanyin MM10; Li, JingJing MM11; Wang, Xiaoyue PhD12; Han, Feng BM13; Zhuang, Kun MM14; Zhang, Dekui MM15; Xu, Huanhai MM16; Ding, Jin MM17; Zhang, Xu BE2; Shen, Yuqin BM1; Lin, Hai MM18; Zhang, Zhe MM19; Kim, John J. MD, MS20; Liu, Jiquan PhD2; Hu, Weiling PhD1,3,4; Duan, Huilong PhD2; Si, Jianmin MD1,3,4
doi : 10.14309/ctg.0000000000000385
August 2021 - Volume 12 - Issue 8 - p e00385
Patients with atrophic gastritis (AG) or gastric intestinal metaplasia (GIM) have elevated risk of gastric adenocarcinoma. Endoscopic screening and surveillance have been implemented in high incidence countries. The study aimed to evaluate the accuracy of a deep convolutional neural network (CNN) for simultaneous recognition of AG and GIM.
A Novel Deep Learning System for Diagnosing Early Esophageal Squamous Cell Carcinoma: A Multicenter Diagnostic Study
Tang, Dehua PhD1; Wang, Lei MD, PhD1; Jiang, Jingwei MSc1; Liu, Yuting MSc2; Ni, Muhan MSc1; Fu, Yiwei MSc3; Guo, Huimin MD, PhD1; Wang, Zhengwen MSc2; An, Fangmei MD, PhD4; Zhang, Kaihua PhD2; Hu, Yanxing PhD5; Zhan, Qiang MD, PhD4; Xu, Guifang MD, PhD1; Zou, Xiaoping MD1
doi : 10.14309/ctg.0000000000000393
August 2021 - Volume 12 - Issue 8 - p e00393
This study aims to construct a real-time deep convolutional neural networks (DCNNs) system to diagnose early esophageal squamous cell carcinoma (ESCC) with white light imaging endoscopy.
The Number of Interstitial Cells of Cajal Differs Among Different Subtypes of Achalasia and is Related to Patients' Prognosis
Chen, Songfeng MD1; Zhang, Mengyu MD, PhD1; Liang, Mengya MD, PhD2; Tan, Niandi MD, PhD1; Cui, Yi MD, PhD1; Wang, Jinhui MD, PhD1; Xin, Xiangbin MD, PhD1; Ye, Ziyin MD, PhD3; Zhuang, Qianjun MD, PhD1; Xiao, Yinglian MD, PhD1
doi : 10.14309/ctg.0000000000000388
August 2021 - Volume 12 - Issue 8 - p e00388
Achalasia is a primary esophageal motility disorder with heterogeneous manometric subtypes and prognosis, characterized by degeneration of the esophageal myenteric plexus, and reduction in interstitial cells of Cajal (ICCs). This study aimed to explore the histopathologic characteristics of lower esophageal sphincter (LES) muscle from patients with achalasia with different subtypes and different prognosis.
[beta]6-Integrin Serves as a Potential Serum Marker for Diagnosis and Prognosis of Pancreatic Adenocarcinoma
Lenggenhager, Daniela MD1; Bengs, Susan PhD2,3; Fritsch, Ralph MD4,5; Hussung, Saskia MD4,5; Busenhart, Philipp MD6; Endhardt, Katharina MD1; Töpfer, Antonia MD1; The, Frans Olivier PhD6; Bütikofer, Simon MD7; Gubler, Christoph MD6; Scharl, Michael MD6; Morell, Bernhard MD6
doi : 10.14309/ctg.0000000000000395
August 2021 - Volume 12 - Issue 8 - p e00395
Despite enormous efforts during the past decades, pancreatic adenocarcinoma (PAC) remains one of the most deleterious cancer entities. A useful biomarker for early detection or prognosis of PAC does not yet exist. The goal of our study was the characterization of ?6-integrin (ITGB6) as a novel serum tumor marker for refined diagnosis and prognosis of PAC. Serum ITGB6 levels were analyzed in 3 independent PAC cohorts consisting of retrospectively and prospectively collected serum and/or (metastatic) PAC tissue specimens.
Two Different 1-Week Quadruple Therapies Given Back-to-Back Consecutive Therapy for Difficult-to-Treat Helicobacter pylori Infection: A Pilot Study
Liu, Jing MD1,2,3; Ji, Chao-Ran MD1,2,3; Li, Yue-Yue MD1,2,3; Qiao, Chen MD1,2,3; Hu, Jun-Nan MD1,2,3; Wan, Meng BD1,2,3; Lin, Min-Juan BD1,2,3; Lin, Bo-Shen BD1,2,3; Wang, Juan BD1,2,3; Zha, Jing BD1,2,3; Li, Li-Xiang PhD1,2,3; Zuo, Xiu-Li MD, PhD1,2,3
doi : 10.14309/ctg.0000000000000391
August 2021 - Volume 12 - Issue 8 - p e00391
We aim to evaluate the efficacy of 2 different 1-week quadruple therapies given back-to-back consecutive therapy in patients with difficult-to-treat Helicobacter pylori infection.
