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Longitudinal Oral Anticoagulant Adherence Trajectories in Patients With Atrial Fibrillation
ShahrzadSalmasiPhDabMary A.De VeraPhDabcAbdollahSafariPhDbdLarry D.LyndPhDabceMiekeKoehoornPhDeArden R.BarryPharmDbJason G.AndradeMDfgMarc W.DeyellMD, MSchiKathyRushPhDjYinshanZhaoPhDhPeterLoewenPharmDabi
doi : 10.1016/j.jacc.2021.09.1370
Volume 78, Issue 24, 14 December 2021, Pages 2395-2404
Conventional adherence summary measures do not capture the dynamic nature of adherence.
Can We Anticipate Nonadherence to Anticoagulation??: Elegant Modeling, But No Clear Predictions
Allan C.SkanesMDLorne J.GulaMD
doi : 10.1016/j.jacc.2021.10.016
Volume 78, Issue 24, 14 December 2021, Pages 2405-2407
Outcomes Stratified by Adapted Inclusion Criteria After Mitral Edge-to-Edge Repair
BenediktKoellMDabMathiasOrbanMDcJessicaWeimannMScaMohammadKassarMDdNicoleKaramMDeMichaelNeussMDfAnielaPetrescuMDgChristosIliadisMDhMatthiasUnterhuberMDiMariannaAdamoMDjCristinaGianniniMDkBrunoMelicaMDlSebastianLudwigMDabSteffenMassbergMDcFabienPrazMDdRomanPfisterMDhHolgerThieleMDiRalphStephan von BardelebenMDgStephanBaldusMDhChristianButterMDfPhilippLurzMD, PhDiStephanWindeckerMDdMarcoMetraMDjAnna SoniaPetronioMDkJörgHausleiterMDcEdithLubosMDaDanielKalbacherMDabon behalf of theEuroSMR Investigators
doi : 10.1016/j.jacc.2021.10.011
Volume 78, Issue 24, 14 December 2021, Pages 2408-2421
Although mitral valve transcatheter edge-to-edge repair (M-TEER) achieves symptomatic benefit for a broad spectrum of patients with relevant secondary mitral regurgitation, conflicting data exist on its prognostic impact.
The Complex Phenotypic Expressions of Functional Mitral Regurgitation?
Paul A.GrayburnMDMiltonPackerMD
doi : 10.1016/j.jacc.2021.10.010
Volume 78, Issue 24, 14 December 2021, Pages 2422-2424
Microcirculatory Resistance Predicts Allograft Rejection and Cardiac Events After Heart Transplantation
Jung-MinAhnMDab?Frederik M.ZimmermannMDbc?LarsGullestadMD, PhDdefgOskarAngeråsMDhiKristjanKarasonMDhiKristofferRussellMD, PhDdKetilLundeMD, PhDdKozoOkadaMDjHelenLuikartRN, MSNbKiran K.KhushMDbYasuhiroHondaMDbNico H.J.PijlsMD, PhDcSang EunLeeMDaJae-JoongKimMD, PhDaSeung-JungParkMD, PhDaOle-GeirSolbergMD, PhDdWilliam F.FearonMDbk
doi : 10.1016/j.jacc.2021.10.009
Volume 78, Issue 24, 14 December 2021, Pages 2425-2435
Single-center data suggest that the index of microcirculatory resistance (IMR) measured early after heart transplantation predicts subsequent acute rejection.
Probing the Microvasculature for Long-Term Gains in Heart Transplant Recipients?
G. WilliamDecMDJagatNarulaMD, PhD
doi : 10.1016/j.jacc.2021.10.013
Volume 78, Issue 24, 14 December 2021, Pages 2436-2438
Stabilizing Ryanodine Receptors Improves Left Ventricular Function in Juvenile Dogs With Duchenne Muscular Dystrophy
OlivierCazorlaPhDaInèsBarthélémyVMD-PhDbcJin BoSuPhDbcAlbano C.MeliPhDaValérieChetboulVMD-PhDbcValérieScheuermannMScaVassilikyGouniVMD-PhDbcCamilleAnglerotMScaSylvainRichardPhDaStéphaneBlotVMD-PhDbcBijanGhalehPhDbc?AlainLacampagnePhDa?
doi : 10.1016/j.jacc.2021.10.014
Volume 78, Issue 24, 14 December 2021, Pages 2439-2453
Duchenne muscular dystrophy is associated with progressive deterioration in left ventricular (LV) function. The golden retriever muscular dystrophy (GRMD) dog model recapitulates the pathology and clinical manifestations of Duchenne muscular dystrophy. Importantly, they develop progressive LV dysfunction starting at early age.
Ryanodine Receptors Matter for Cardiac Function in Duchenne Muscular Dystrophy: Stability First?
ChristianKupattMDTarikBozogluPhD
doi : 10.1016/j.jacc.2021.10.012
Volume 78, Issue 24, 14 December 2021, Pages 2454-2456
Race, Ethnicity, and Cardiovascular Disease: JACC Focus Seminar Series
George A.MensahMDaValentinFusterMD, PhDbc
doi : 10.1016/j.jacc.2021.11.001
Volume 78, Issue 24, 14 December 2021, Pages 2457-2459
Race, Ethnicity, Hypertension, and Heart Disease: JACC Focus Seminar 1/9
Modele O.OgunniyiMD, MPHabYvonneCommodore-MensahPhD, MHS, RNcdKeith C.FerdinandMDe
doi : 10.1016/j.jacc.2021.06.017
Volume 78, Issue 24, 14 December 2021, Pages 2460-2470
Hypertension is the leading cause of cardiovascular morbidity and mortality globally. In the United States, the prevalence of hypertension (blood pressure ?130/80 mm Hg) among adults is approximately 45%. Racial/ethnic disparities in hypertension prevalence are well documented, especially among Black adults who are disproportionately affected and have one of the highest rates of hypertension globally. Hypertension control remains a persistent public health crisis. Recently published data indicate suboptimal hypertension control rates, particularly for racial/ethnic minority groups in the United States. This requires urgent action because of the significant health care burden from cardiovascular- and stroke–related morbidity and mortality. This clinical review delineates racial/ethnic disparities in the epidemiology of hypertension, and the impact of social determinants of health on the quality of cardiovascular care and outcomes. Clinical practice guideline recommendations and various national programs targeted toward hypertension control and proposed solutions to eliminate these disparities are discussed.
Cardiovascular Impact of Race and Ethnicity in Patients With Diabetes and Obesity: JACC Focus Seminar 2/9
Joshua J.JosephMD, MPHaRobinOrtizMDbTusharAcharyaMD, MPHcSherita H.GoldenMD, MHSdLennyLópezMD, MPH, MDivePrakashDeedwaniaMDf
doi : 10.1016/j.jacc.2021.06.020
Volume 78, Issue 24, 14 December 2021, Pages 2471-2482
Obesity and type 2 diabetes mellitus are highly prevalent and increasing in the United States among racial/ethnic minority groups. Type 2 diabetes mellitus, which is driven by many factors including elevated levels of adiposity, is an exemplar health disparities disease. Pervasive disparities exist at every level from risk factors through outcomes for U.S. racial/ethnic minority groups, including African American, Hispanic/LatinX American, and Asian American populations. Disparities in clinical care exist including hemoglobin A1c control, lower prescription rates of newer antihyperglycemic medications, along with greater rates of complications postbariatric surgery. Underpinning these disparities are the social determinants of health affecting provider–patient interactions, access to resources, and healthy built environments. We review the best practices to address cardiometabolic disparities in the current cardiovascular guidelines and describe recommendations for cross-cutting strategies to advance equity in obesity and type 2 diabetes across U.S. racial/ethnic groups.
Race and Ethnicity Considerations in Patients With Coronary Artery Disease and Stroke: JACC Focus Seminar 3/9
RohitMitalMDaJosephBayneMDaFatimaRodriguezMD, MPHbBruceOvbiageleMD, MSc, MAS, MBAcDeepak L.BhattMD, MPHdMichelle A.AlbertMD, MPHa
doi : 10.1016/j.jacc.2021.05.051
Volume 78, Issue 24, 14 December 2021, Pages 2483-2492
Notable racial and ethnic differences and disparities exist in coronary artery disease (CAD) and stroke epidemiology and outcomes despite substantial advances in these fields. Racial and ethnic minority subgroups remain underrepresented in population data and clinical trials contributing to incomplete understanding of these disparities. Differences in traditional cardiovascular risk factors such as hypertension and diabetes play a role; however, disparities in care provision and process, social determinants of health including socioeconomic position, neighborhood environment, sociocultural factors, and racial discrimination within and outside of the health care system also drive racial and ethnic CAD and stroke disparities. Improved culturally congruent and competent communication about risk factors and symptoms is also needed. Opportunities to achieve improved and equitable outcomes in CAD and stroke must be identified and pursued.
Valvular Heart Disease in Relation to Race and Ethnicity: JACC Focus Seminar 4/9
Julio A.Lamprea-MontealegreMD, PhDaShakiratOyetunjiMDbRodrigoBagurMD, PhDcCatherine M.OttoMDd
doi : 10.1016/j.jacc.2021.04.109
Volume 78, Issue 24, 14 December 2021, Pages 2493-2504
Valvular heart disease (VHD) is a major global public health problem. Many regions of the world continue to grapple with the adverse consequences of untreated rheumatic heart disease, a condition that is largely preventable with timely access to diagnosis and treatment. In turn, middle- and high-income countries have experienced a rise in the prevalence of calcific aortic and mitral disease, owing in part to population aging. This public health problem is further compounded by high rates of infective endocarditis, which is associated with substantial morbidity and mortality. Yet, considerations of race and ethnicity have not taken center stage in VHD research. This is despite evidence of major health care disparities in socioeconomic and medical risk factors, access to diagnosis, and provision of appropriate treatment. In this paper, the authors review differences in the etiology, diagnosis, and treatment of VHD within the context of race, ethnicity, and health care disparities.
A Promising Step Forward in LVNC Risk Stratification, But How Much Trabeculation Can Be Normal?
AndrewD’SilvaMBBS, BSc, PhD
doi : 10.1016/j.jacc.2021.08.076
Volume 78, Issue 24, 14 December 2021, Page e307
Reply: A Promising Step Forward in LVNC Risk Stratification, But How Much Trabeculation Can Be Normal?
José F.Rodríguez-PalomaresMD, PhDGuillemCasasMDAndreaGualaPhDJavierLimeresMDIgnacioFerreira-GonzálezMD, PhD
doi : 10.1016/j.jacc.2021.10.008
Volume 78, Issue 24, 14 December 2021, Page e309
Plant-Based Diet, Gut Microbiota, and Bioavailability of Lignans
AmudhaKumarMDVigneshChidambaramMD, MPHJawahar L.MehtaMD, PhD
doi : 10.1016/j.jacc.2021.09.1369
Volume 78, Issue 24, 14 December 2021, Page e311
Reply: Plant-Based Diet, Gut Microbiota, and Bioavailability of Lignans
YangHuScDQiSunMD, ScD
doi : 10.1016/j.jacc.2021.10.007
Volume 78, Issue 24, 14 December 2021, Page e313
