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Aortic Valve Replacement in Low-Risk Patients With Severe Aortic Stenosis Outside Randomized Trials
Alberto Alperi, Pierre Voisine, Dimitri Kalavrouziotis, Eric Dumont, ... Josep Rodés-Cabau
doi : 10.1016/j.jacc.2020.10.056
Volume 77, Issue 2, 19 January 2021, Pages 111-123
Recent randomized trials including low-risk patients showed positive results for transcatheter aortic valve replacement (TAVR) compared to surgical aortic valve replacement (SAVR), but patients with non-tricuspid aortic valve (NTAV), severe coronary artery disease (SevCAD), and those requiring concomitant mitral/tricuspid valve (CMTV) or concomitant ascending aorta replacement (CAAR) interventions were excluded.
When Excluded From Randomized Clinical Trials: To “OR” or “‘TAVR”?
Poonam Velagapudi, Vinayak Bapat, Susheel Kodali
doi : 10.1016/j.jacc.2020.11.049
Volume 77, Issue 2, 19 January 2021, Pages 124-127
Prevalence and Outcomes of Concomitant Aortic Stenosis and Cardiac Amyloidosis
Christian Nitsche, Paul R. Scully, Kush P. Patel, Andreas A. Kammerlander, ... Thomas A. Treibel
doi : 10.1016/j.jacc.2020.11.006
Volume 77, Issue 2, 19 January 2021, Pages 128-139
Older patients with severe aortic stenosis (AS) are increasingly identified as having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has worse outcomes or results in futility of transcatheter aortic valve replacement (TAVR).
Concomitant Cardiac Amyloidosis in Severe Aortic Stenosis: The Trojan Horse?
Philippe Pibarot, Patrizio Lancellotti, Jagat Narula
doi : 10.1016/j.jacc.2020.11.007
Volume 77, Issue 2, 19 January 2021, Pages 140-143
Predictive Value of the Residual SYNTAX Score in Patients With Cardiogenic Shock
Olivier Barthélémy, Stéphanie Rouanet, Delphine Brugier, Nicolas Vignolles, ... Gilles Montalescot
doi : 10.1016/j.jacc.2020.11.025
Volume 77, Issue 2, 19 January 2021, Pages 144-155
Residual SYNTAX Score After Revascularization in Cardiogenic Shock: When Is Complete Complete?
Ajar Kochar, Anubodh S. Varshney, David E. Wang
doi : 10.1016/j.jacc.2020.11.034
Volume 77, Issue 2, 19 January 2021, Pages 156-158
Volume 77, Issue 2, 19 January 2021, Pages 156-158
Rishi K. Wadhera, Changyu Shen, Suhas Gondi, Siyan Chen, ... Robert W. Yeh
doi : 10.1016/j.jacc.2020.10.055
Volume 77, Issue 2, 19 January 2021, Pages 159-169
Although the direct toll of COVID-19 in the United States has been substantial, concerns have also arisen about the indirect effects of the pandemic. Hospitalizations for acute cardiovascular conditions have declined, raising concern that patients may be avoiding hospitals because of fear of contracting severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2). Other factors, including strain on health care systems, may also have had an indirect toll.
COVID-19 and Cardiovascular Health: This Is a Public Service Announcement
Michael N. Young, Alexander Iribarne, David Malenka
doi : 10.1016/j.jacc.2020.11.027
Volume 77, Issue 2, 19 January 2021, Pages 170-172
International Impact of COVID-19 on the Diagnosis of Heart Disease
Darryl P. Leong, John W. Eikelboom, Salim Yusuf
doi : 10.1016/j.jacc.2020.10.054
Volume 77, Issue 2, 19 January 2021, Pages 173-185
The Indirect Consequences of the Response to the COVID-19 Pandemic
Darryl P. Leong, John W. Eikelboom, Salim Yusuf
doi : 10.1016/j.jacc.2020.11.028
Volume 77, Issue 2, 19 January 2021, Pages 186-188
Cardiovascular Aging and Longevity: JACC State-of-the-Art Review
Panagiota Pietri, Christodoulos Stefanadis
doi : 10.1016/j.jacc.2020.11.023
Volume 77, Issue 2, 19 January 2021, Pages 189-204
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dyslipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goal of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations.
Cardiovascular Complications of Opioid Use: JACC State-of-the-Art Review
Mori J. Krantz, Robert B. Palmer, Mark C.P. Haigney
doi : 10.1016/j.jacc.2020.11.002
Volume 77, Issue 2, 19 January 2021, Pages 205-223
Opioids are the most potent of all analgesics. Although traditionally used solely for acute self-limited conditions and palliation of severe cancer-associated pain, a movement to promote subjective pain (scale, 0 to 10) to the status of a “fifth vital sign” bolstered widespread prescribing for chronic, noncancer pain. This, coupled with rising misuse, initiated a surge in unintentional deaths, increased drug-associated acute coronary syndrome, and endocarditis. In response, the American College of Cardiology issued a call to action for cardiovascular care teams. Opioid toxicity is primarily mediated via potent ?-receptor agonism resulting in ventilatory depression. However, both overdose and opioid withdrawal can trigger major adverse cardiovascular events resulting from hemodynamic, vascular, and proarrhythmic/electrophysiological consequences. Although natural opioid analogues are devoid of repolarization effects, synthetic agents may be proarrhythmic. This perspective explores cardiovascular consequences of opioids, the contributions of off-target electrophysiologic properties to mortality, and provides practical safety recommendations.
NCDR: Advancing Patient Care, Outcomes, and Value Through Innovation and Knowledge
Athena Poppas, Frederick A. Masoudi
doi : 10.1016/j.jacc.2020.12.001
Volume 77, Issue 2, 19 January 2021, Pages 224-226
Management of Cardiogenic Shock During COVID-19: The IHVI Experience
Carolyn M. Rosner, Behnam N. Tehrani, Alexander G. Truesdell, Shashank S. Sinha, ... Wayne B. Batchelor
doi : 10.1016/j.jacc.2020.11.026
Volume 77, Issue 2, 19 January 2021, Pages 227-228
