دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Decline in Sars-CoV-2 antibodies over 6-month follow-up in obstetrical healthcare workers
Miranda K. Kiefer,Kenneth D. Allen,Jessica R. Russo,Marwan Ma'ayeh,Stephen E. Gee,Doug Kniss,Michael Cackovic,Maged M. Costantine,Kara M. Rood
doi : 10.1111/aji.13490
Volume 86, Issue 6 e13490
Limited data exists on the temporal trend of the Sars-CoV-2 immunologic response and duration of protection following natural infection. We sought to investigate the presence and duration of Sars-CoV-2 serum antibodies in obstetrical healthcare workers (HCW) on serial assessments over a 6-month period, and to assess rates of vaccine acceptance and reported vaccine side effects among this cohort.
Maternal and fetal safety of intravenous immunoglobulin in women with reproductive failure
Aera Han,Sung Ki Lee,Joon Cheol Park,Chan Woo Park,Jae Won Han,Ki Hwan Lee
doi : 10.1111/aji.13492
Volume 86, Issue 6 e13492
Intravenous immunoglobulin G (IVIG) is an emerging regimen for women with reproductive failures (RF) during- or pre-pregnancy who have aberrant cellular immune reactions. Studies investigating teratogenicity of IVIG have been limited. Herein, we evaluated the fetal teratogenicity of IVIG and IVIG-related obstetric complications.
Molecular mimicry between SARS-CoV-2 and the female reproductive system
Arad Dotan,Darja Kanduc,Sylviane Muller,Alexander Makatsariya,Yehuda Shoenfeld
doi : 10.1111/aji.13494
Volume 86, Issue 6 e13494
Oogenesis, the process of egg production by the ovary, involves a complex differentiation program leading to the production of functional oocytes. This process comprises a sequential pathway of steps that are finely regulated. The question related to SARS-CoV-2 infection and fertility has been evoked for several reasons, including the mechanism of molecular mimicry, which may contribute to female infertility by leading to the generation of deleterious autoantibodies, possibly contributing to the onset of an autoimmune disease in infected patients.
Using principal component analysis to examine associations of early pregnancy inflammatory biomarker profiles and adverse birth outcomes
Lauren S. Keenan-Devlin,Madeleine Caplan,Alexa Freedman,Kristine Kuchta,William Grobman,Claudia Buss,Emma K. Adam,Sonja Entringer,Gregory E. Miller,Ann E.B. Borders
doi : 10.1111/aji.13497
Volume 86, Issue 6 e13497
Inflammation as a risk factor for preterm birth is well-established. The primary objective of this analysis was to examine whether individual cytokines versus a composite indicator of mid-pregnancy inflammation are significantly associated with risk for adverse birth outcomes.
Decreased occurrence of endometriosis in women with Chlamydia trachomatis infection
Khaleque N. Khan,Akira Fujishita,Michio Kitajima,Tadayuki Ishimaru,Kanae Ogawa,Akemi Koshiba,Taisuke Mori,Jo Kitawaki
doi : 10.1111/aji.13498
Volume 86, Issue 6 e13498
Despite abundant reports on the risk role of uterine outflow tract obstruction in endometriosis, information on the occurrence of endometriosis in women with Chlamydia trachomatis infection causing fallopian tube obstruction is unknown. We investigated the role of Chlamydia trachomatis infection with or without fallopian tubal patency in the occurrence of endometriosis.
Soluble human leukocyte antigen-G is a potential embryo viability biomarker and a positive predictor of live-births in humans
Venkatappa Vani,Satya S. Vasan,Satish K. Adiga,Samson Roy Varsha,Geetanjali Sachdeva,Pratap Kumar,Polani B. Seshagiri
doi : 10.1111/aji.13499
Volume 86, Issue 6 e13499
Human infertility affects 15–20% of reproductive-age couples and it is mitigated by assisted reproductive technology (ART) approaches. Poor biological viability of embryos contributes to implantation failure and live birth rate (LBR). This study is aimed to examine whether or not embryo-secreted soluble human leukocyte antigen-G (sHLA-G) is (i) associated with developing embryos and (ii) able to predict successful pregnancy outcome.
Expression of the alternative splicing regulator Rbfox2 during placental development is differentially regulated in preeclampsia mouse models
Nancy Freitag,Yiran Xie,Lisa-Marie Adam,Sophia Borowski,Sandra M. Blois,Gabriela Barrientos
doi : 10.1111/aji.13491
Volume 86, Issue 6 e13491
Proper placental development is pivotal to ensure healthy pregnancy outcomes. Among the multiple cellular mechanisms involved in the orchestration of this process, little is known on the role of alternative splicing events in the modulation of trophoblast cell biology. Here, we evaluated the expression of the alternative splicing regulator Rbfox2 in the pre- and post-placentation period in mouse pregnancies in both healthy and pathological settings.
Multiomic analysis reveals decidual-specific transcriptional programing of MAIT cells
Jessica Vazquez,Melina Chavarria,Deborah A. Chasman,Rene Welch Schwartz,Chanel T. Tyler,Gladys Lopez,Rachel C. Fisher,Irene M. Ong,Aleksandar K. Stanic
doi : 10.1111/aji.13495
Volume 86, Issue 6 e13495
Mucosal-Associated Invariant T (MAIT) cells have been recently identified at the maternal-fetal interface. However, transcriptional programming of decidual MAIT cells in pregnancy remains poorly understood.
The FSHR G-29A variant is not associated with the ovarian response to exogenous FSH stimulation
Di Song,Ling Hong,Zhao-feng Zhang,Jian-hua Xu,Hui-qin Zhang,Xian-liang Huang,Jing Du
doi : 10.1111/aji.13500
Volume 86, Issue 6 e13500
A common genetic variant in the follicle stimulating hormone receptor gene (FSHR) 5?-untranslated region has been previously reported to influence FSHR gene expression. However, studies on the ovarian response to exogenous gonadotropin stimulation are limited. The aim of this study was to evaluate the association of variants at positions -29 of the FSHR gene with the ovarian response to exogenous FSH stimulation in Chinese women. The genotypes of the FSHR gene were assayed using the Sequenom MassARRAY system. Total RNA and protein was extracted from granulosa cells, and FSHR expression at the mRNA and protein levels was assessed using quantitative PCR and western blotting. Our data revealed that there was no association between the FSHR genotype at the -29 position and the outcome of controlled ovarian stimulation. The expression of FSHR, at both the mRNA and protein levels, was similar amongst the different FSHR genotypes assessed, but was significantly reduced in the low responders. These results indicate that the variants caused by mutations at position -29 are not associated with ovarian response, and the low ovarian response to gonadotropin stimulation may be caused by decreased FSHR expression.
Increased uterine NLRP3 inflammasome and leucocyte infiltration in a rat model of preeclampsia
Huiqian Zeng,Xinjia Han,Zhiqin Zhu,Shengjun Yu,Shanshan Mei,Xi Cheng,Weiqiang Zhang,Guanglan Zhang,Dajun Fang
doi : 10.1111/aji.13493
Volume 86, Issue 6 e13493
The disruption of the inflammatory microenvironment in the uterus affects pregnancy outcome. However, the exact quantification and distribution of leukocyte subpopulations in the uterus in preeclampsia (PE) have not been clearly characterized. Inflammasomes promote the release of proinflammatory cytokines interleukin (IL)-? and IL-18. A higher expression of NLRP3 inflammasome in placentas contributes to excessive inflammation in PE. However, related studies on the uterus are scarce. We aimed to investigate changes in the infiltration of leukocyte subpopulations in decidual and uterine tissues, and explore the role of activation of uterine NLRP3 inflammasomes in PE. Decidual tissues were collected from normotensive pregnant women and preeclamptic women. A PE-like model was established via administration of lipopolysaccharide to normal pregnant rats. Uterine and decidual tissues were collected from all experimental groups. It was found that the number of leukocytes was significantly elevated in decidual and uterine tissues in PE patients compared to normal controls. The leukocytes (predominantly macrophages and NK cells) particularly infiltrated into the decidua and uterine decidua in PE-like rats, and these were sparse in the myometrium. The NLRP3 immunoreactivity in the uterus was extremely little in control rats, its immunoreactivity and caspase-1 immunoreactivity were significantly elevated in the PE-like rats; the mRNA expression results also indicated an upward trend in the activation of NLRP3 inflammasomes. These results support that leucocyte infiltration in the decidua and uterine deciduas, and the activation of NLRP3 inflammasome in the uterus, which participate in the pathogenesis, are responsible for the excessive inflammation at the maternal-fetal interface during PE.
The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review
Ourlad Alzeus G. Tantengco,Mariana de Castro Silva,Hend Shahin,Giovana Fernanda Cosi Bento,Geovanna Cristofani Cursino,Samir Cayenne,Marcia Guimarães da Silva,Ramkumar Menon
doi : 10.1111/aji.13496
Volume 86, Issue 6 e13496
A homeostatic balance between reactive oxygen species production and the antioxidant redox system is an important component of normal pregnancy. Nuclear Factor Erythroid 2–Related Factor 2 (Nrf2) preserves cellular homeostasis by enhancing the cell's innate antioxidant status to reduce oxidative stress and inflammatory damage to the cell during pregnancy. Active Nrf2, in the nucleus of the cell, transactivates various antioxidant genes. The objective of this systematic review was to synthesize evidence on the role of Nrf2 in various adverse pregnancy outcomes (APOs).
Group B streptococcal infection of the genitourinary tract in pregnant and non-pregnant patients with diabetes mellitus: An immunocompromised host or something more?
Lynsa M. Nguyen,Joel I. Omage,Kristen Noble,Kelsey L. McNew,Daniel J. Moore,David M. Aronoff,Ryan S. Doster
doi : 10.1111/aji.13501
Volume 86, Issue 6 e13501
Group B Streptococcus (GBS), also known as Streptococcus agalactiae is a Gram-positive bacterium commonly encountered as part of the microbiota within the human gastrointestinal tract. A common cause of infections during pregnancy, GBS is responsible for invasive diseases ranging from urinary tract infections to chorioamnionitis and neonatal sepsis. Diabetes mellitus (DM) is a chronic disease resulting from impaired regulation of blood glucose levels. The incidence of DM has steadily increased worldwide to affecting over 450 million people. Poorly controlled DM is associated with multiple health comorbidities including an increased risk for infection. Epidemiologic studies have clearly demonstrated that DM correlates with an increased risk for invasive GBS infections, including skin and soft tissue infections and sepsis in non-pregnant adults. However, the impact of DM on risk for invasive GBS urogenital infections, particularly during the already vulnerable time of pregnancy, is less clear. We review the evolving epidemiology, immunology, and pathophysiology of GBS urogenital infections including rectovaginal colonization during pregnancy, neonatal infections of infants exposed to DM in utero, and urinary tract infections in pregnant and non-pregnant adults in the context of DM and highlight in vitro studies examining why DM might increase risk for GBS urogenital infection.
Obituary
David A. Clark,Nathalie Ledee,Udo R. Markert,Elisabeth Menu,Julia Szekeres-Bartho
doi : 10.1111/aji.13473
Volume 86, Issue 6 e13473
